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Protein Overview: Rrp46-PA

General Information:
Name(s) found: Rrp46-PA / FBpp0081725 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Rrp46 is referred to in FlyBase by the symbol Dmel\Rrp46 (CG4043, FBgn0037815). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:6239023..6239968. It has the cytological map location 86B4. Based on sequence similarity, it is predicted to have molecular function</span>: 3'-5'-exoribonuclease activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: mRNA processing. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 233 amino acids

    Gene Ontology:
    Cellular Component: cytoplasmic exosome (RNase complex) [ISS]
    nuclear exosome (RNase complex) [IPI][ISS]
    cytoplasm [IDA]
    Biological Process: mRNA processing [ISS]
    Molecular Function: 3'-5'-exoribonuclease activity [ISS]
    RNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLPAKMDVE KDKLRQMHCE FNPLSRCDGS VMYSQGATGL IGAVLGPIEV KTQNLSIDGS  60
   61 YLECNYRPKA GLPQVTDRIR EAAIRDVLEL ALLSEAHPRS KMSVQIQELE DRGSIDACAV 120
  121 NCACLAMLIG GLPLKYSFAA VHAIINEQGE YVLDPDQSET LHQRASFTFA FDSVEGNLLL 180
  181 IQTKGSFKIA QFNDIECLCL AASAEIFQFY RNQVAKYHGR SEATAKKEDV NET

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..233] PSI-BLAST 40.0 No description for 2nn6D was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 3'-5'-exoribonuclease activity
    		•  6.46930372693262 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  6.29937266123635 bayes_pls_golite062009
  • exoribonuclease activity
    		•  6.25059972010432 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  5.06256868878098 bayes_pls_golite062009
  • ribonuclease activity
    		•  4.90722443274963 bayes_pls_golite062009
  • exonuclease activity
    		•  4.6643790818023 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  4.29895100594643 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.86434572018929 bayes_pls_golite062009
  • RNA binding
    		•  2.05527376734941 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.90115575554186 bayes_pls_golite062009
  • structural molecule activity
    		•  1.69321127364043 bayes_pls_golite062009
  • hydrolase activity
    		•  1.55476709794855 bayes_pls_golite062009
  • binding
    		•  1.3018457178158 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.20748032530392 bayes_pls_golite062009
  • mRNA binding
    		•  1.17402119891853 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.05662964529454 bayes_pls_golite062009
  • catalytic activity
    		•  0.878454819018611 bayes_pls_golite062009
  • DNA binding
    		•  0.828609700556836 bayes_pls_golite062009
  • nuclease activity
    		•  0.69721312877891 bayes_pls_golite062009
  • tRNA-specific ribonuclease activity
    		•  0.383567539949931 bayes_pls_golite062009
  • deacetylase activity
    		•  0.2046781383773 bayes_pls_golite062009
  • protein binding
    		•  0.0913090112555771 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle