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Protein Overview: mthl11-PA

General Information:
Name(s) found: mthl11-PA / FBpp0081724 [FlyBase]
Description(s) found:
Found 13 descriptions.
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  • The gene methuselah-like 11 is referred to in FlyBase by the symbol Dmel\mthl11 (CG31147, FBgn0045443). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:6226767..6228551. It has the cytological map location 86B3-86B4. Based on sequence similarity, it is predicted to have molecular function</span>: G-protein coupled receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: G-protein coupled receptor protein signaling pathway; determination of adult lifespan; response to stress. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 510 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    integral to membrane [NAS]
    Biological Process: G-protein coupled receptor protein signaling pathway [ISS]
    determination of adult lifespan [ISS]
    cell surface receptor linked signaling pathway [IEA]
    response to stress [ISS]
    Molecular Function: G-protein coupled receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGMFRVEYLL LGILVIGVRS RDIPNCDFFD TVQLRESEKL CNGSYRYEDV VIPAKLTGKY  60
   61 DYEIDYDGDR VSVPKHIRGC VCKLKTCIRF CCHHKKLMAG NLCSQDVYEN LTYEYTLDIT 120
  121 QLNGSVIKKH VLNDMVVQQD LPLPCERHYS LDAETSTYDM WSLYENGSLF RHFDQRYLSK 180
  181 QEFCLQPNPT STGKNYSLIV AFNCIQKPSM KMAYGRFECV RKSRLSNASI PVKFSSVFFM 240
  241 VITIAAYLWL PKFRSLHGKC CNLYFICLAI TFLLNVISLF GIFELKTPIC YLTGYAGYFT 300
  301 VMATFLWLSV ISFDVWRRFA MRKFQVFYKN KRSSFFNYNI IVWSSAGLLT CIIFLVDQFV 360
  361 ETNLDNPYNP AVGVFSCWIF TNGWSATFYF YAPLAILIIL NCASFFLTTR YIYVENKQNQ 420
  421 KVLNNSEPQK LSRNHANYRI YFRLFIIMGG SWFLEIIAFI CEMENMWKPL IILNDYINCS 480
  481 QGIIIFVATF CNHEMFRLIR KRWVFCDSTP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..196] PSI-BLAST 52.221849 Methuselah ectodomain
    2 View Details [197..510] PSI-BLAST 56.522879 Rhodopsin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • G-protein coupled receptor activity
    		•  7.48253527316663 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  5.76968261800439 bayes_pls_golite062009
  • receptor activity
    		•  5.47976284348283 bayes_pls_golite062009
  • signal transducer activity
    		•  4.51388461085202 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.51388461085202 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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