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Protein Overview: tws-PA, FBpp0311...

General Information:
Name(s) found: FBpp0311386 [FlyBase]
tws-PF / FBpp0081665 [FlyBase]
tws-PA / FBpp0081664 [FlyBase]
Description(s) found:
Found 46 descriptions.
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  • type=protein; loc=3R:complement(5953869..5954237,5954352..5955155,5955217..5955368,5960541..5960715); ID=FBpp0311386; name=tws-PI; parent=FBgn0004889,FBtr0345177; dbxref=FlyBase:FBpp0311386,FlyBase_Annotation_IDs:CG6235-PI; MD5=e172bbc5a69f0e8b06b573e62550ede1; length=499; release=r5.56; species=Dmel; [FlyBase]
  • The gene twins is referred to in FlyBase by the symbol Dmel\tws (CG6235, FBgn0004889). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5952523..5965492. It has the cytological map location 85F13-85F14. There is experimental evidence that it has the molecular function</span>: protein phosphatase type 2A regulator activity. There is experimental evidence that it is involved in the biological process</span>: mitotic cell cycle; mitotic anaphase; imaginal disc pattern formation; sensory organ development; embryonic development via the syncytial blastoderm; regulation of mitosis; Wnt receptor signaling pathway. 106 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: peripheral nervous system; organ system; nervous system; cell cycle; eo support cell; germarium; chromosome, centromeric region; wing hair; dorsal thoracic disc; external compound sense organ. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
  • The gene twins is referred to in FlyBase by the symbol Dmel\tws (CG6235, FBgn0004889). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5952523..5965492. It has the cytological map location 85F13-85F14. There is experimental evidence that it has the molecular function</span>: protein phosphatase type 2A regulator activity. There is experimental evidence that it is involved in the biological process</span>: mitotic cell cycle; mitotic anaphase; imaginal disc pattern formation; sensory organ development; embryonic development via the syncytial blastoderm; regulation of mitosis; Wnt receptor signaling pathway. 106 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: peripheral nervous system; organ system; nervous system; cell cycle; eo support cell; germarium; chromosome, centromeric region; wing hair; dorsal thoracic disc; external compound sense organ. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 499 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IDA]
    protein phosphatase type 2A complex [IEA][ISS][NAS]
    Biological Process: negative regulation of neuroblast proliferation [IMP]
    embryonic development via the syncytial blastoderm [IMP]
    regulation of mitosis [IMP]
    protein amino acid dephosphorylation [ISS][NAS]
    Wnt receptor signaling pathway [IGI][IMP]
    mitotic anaphase [IMP]
    maintenance of neuroblast polarity [IMP]
    imaginal disc pattern formation [IMP]
    sensory organ development [IMP]
    mitotic cell cycle [IMP]
    Molecular Function: protein serine/threonine phosphatase activity [ISS]
    protein phosphatase type 2A regulator activity [IMP][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRWGRQSPV LEPPDPQMQT TPPPPTLPPR TFMRQSSITK IGNMLNTAIN INGAKKPASN  60
   61 GEASWCFSQI KGALDDDVTD ADIISCVEFN HDGELLATGD KGGRVVIFQR DPASKAANPR 120
  121 RGEYNVYSTF QSHEPEFDYL KSLEIEEKIN KIRWLQQKNP VHFLLSTNDK TVKLWKVSER 180
  181 DKSFGGYNTK EENGLIRDPQ NVTALRVPSV KQIPLLVEAS PRRTFANAHT YHINSISVNS 240
  241 DQETFLSADD LRINLWHLEV VNQSYNIVDI KPTNMEELTE VITAAEFHPT ECNVFVYSSS 300
  301 KGTIRLCDMR SAALCDRHSK QFEEPENPTN RSFFSEIISS ISDVKLSNSG RYMISRDYLS 360
  361 IKVWDLHMET KPIETYPVHE YLRAKLCSLY ENDCIFDKFE CCWNGKDSSI MTGSYNNFFR 420
  421 VFDRNSKKDV TLEASRDIIK PKTVLKPRKV CTGGKRKKDE ISVDCLDFNK KILHTAWHPE 480
  481 ENIIAVAATN NLFIFQDKF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..499] PSI-BLAST 40.39794 Actin interacting protein 1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.1056443224755 bayes_pls_golite062009
  • tubulin binding
    		•  2.76945430061825 bayes_pls_golite062009
  • microtubule binding
    		•  2.72684103222924 bayes_pls_golite062009
  • dynein binding
    		•  2.54821997913979 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • actin binding
    		•  2.27900251096697 bayes_pls_golite062009
  • hydrolase activity
    		•  1.72636554646684 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.693814013902061 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.579815310385678 bayes_pls_golite062009
  • actin filament binding
    		•  0.554537899540618 bayes_pls_golite062009
  • kinase activity
    		•  0.498626428956965 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.496422970081867 bayes_pls_golite062009
  • snoRNA binding
    		•  0.347797037104681 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.326899344050856 bayes_pls_golite062009
  • structural molecule activity
    		•  0.254012051644049 bayes_pls_golite062009
  • protein kinase activity
    		•  0.245792286293244 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.118975415284669 bayes_pls_golite062009
  • DNA binding
    		•  0.0736878329528894 bayes_pls_golite062009
    		• 0.0248988265652406 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle