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Protein Overview: Scm-PA, FBpp0297150

General Information:
Name(s) found: FBpp0297150 [FlyBase]
Scm-PA / FBpp0081580 [FlyBase]
Description(s) found:
Found 31 descriptions.
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  • type=protein; loc=3R:complement(5460060..5460197,5460259..5461290,5461356..5462273,5462332..5462877); ID=FBpp0297150; name=Scm-PB; parent=FBgn0003334,FBtr0306008; dbxref=REFSEQ:NP_001247006,GB_protein:AFH06324,FlyBase:FBpp0297150,FlyBase_Annotation_IDs:CG9495-PB; MD5=3eefdded9dd59df51d99c654ae195a1b; length=877; release=r5.56; species=Dmel; [FlyBase]
  • The gene Sex comb on midleg is referred to in FlyBase by the symbol Dmel\Scm (CG9495, FBgn0003334). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5459081..5463329. It has the cytological map location 85E2. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: gene silencing; germarium-derived female germ-line cyst encapsulation; ovarian follicle cell stalk formation; axonogenesis; neurogenesis. 42 alleles are reported. The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: larval abdominal segment; adult segment; thoracic segment; larval thorax; larval abdomen; adult mesothoracic segment; organ system; peripheral nervous system; abdominal segment 7; female germline cyst; larval abdominal segment 5; embryonic segment; multidendritic neuron; external compound sense organ; axon. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 877 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    PRC1 complex [TAS]
    Biological Process: gene silencing [IGI][IMP]
    ovarian follicle cell stalk formation [IMP]
    axonogenesis [IMP]
    germarium-derived female germ-line cyst encapsulation [IMP]
    neurogenesis [IMP]
    regulation of transcription [IEA][NAS]
    Molecular Function: zinc ion binding [IEA]
    protein binding [IPI]
    specific RNA polymerase II transcription factor activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGGRDSSTS SGSNSAAPGA STNATSSASA SASSTSTSAS PGSTTSPAST QRQRGRPAKR  60
   61 ATCTWCGEGK LPLQYVLPTQ TGKKEFCSET CIAEFRKAYS KGACTQCDNV IRDGAPNKEF 120
  121 CSIMCMNKHQ KKNCSTRHSG GSASGKGLAE SERKLLASGA PAPTGPFQYE SFHVFDWDAY 180
  181 LEETGSEAAP AKCFKQAQNP PNNDFKIGMK LEALDPRNVT STCIATVVGV LGSRLRLRLD 240
  241 GSDSQNDFWR LVDSTEIHAI GHCEKNGGML QPPLGFRMNA SSWPGYLCKI LNNAMVAPEE 300
  301 IFQPEPPEPE ENLFKVGQKL EAVDKKNPQL ICCATVDAIK DDQIHVTFDG WRGAFDYWCN 360
  361 YRSRDIFPAG WCARSCHPMQ PPGHKSRMDS SSSKQRCPRP RYTVVAESEA MVPASPATAH 420
  421 FHPNCKGGPF INNSKLPCMV TGPTYQTLAK LCLQEVLAAS TDTQQLSKLL FALEGDVHIV 480
  481 TAAGKNFTVK IPSPMRMKDD ESLAQFIETL CTTCRACANL ISLVHETEEC KKCANSRKRQ 540
  541 LTQSATPPSS PVLADKRNRQ SNSATTSPSE KIIKQELAVK SPVESKSKTS TNNGKEPASQ 600
  601 QNSNHSLNNN NNSASKSSNK VVIKSEPNGA NAQTSSTTQA LRKVRFQHHA NTNTNSSATN 660
  661 GNQDTSQTTH VSTSHCSSSS TSSSTSLAGG SANTSTIGKY LAPLVAEVHP EQANVKPSNS 720
  721 YYKSPTTLSS SASLPTSVST PFTGCQSASS TALAAGGVTA AKAATAPAGA AATAGASPSY 780
  781 TAITSPVSTP TSALANSHLR SQPIDWTIEE VIQYIESNDN SLAVHGDLFR KHEIDGKALL 840
  841 LLNSEMMMKY MGLKLGPALK ICNLVNKVNG RRNNLAL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158] FFAS03 3.64 No description for 2i13A was found.
    2 View Details [159..382] PSI-BLAST 93.045757 CRYSTAL STRUCTURE OF THE WILD-TYPE MBT DOMAINS OF HUMAN SCML2
    3 View Details [383..547] deduced N/A No confident structure predictions are available.
    4 View Details [548..801] MSA 2.321997 View MSA. No confident structure predictions are available.
    5 View Details [802..877] PSI-BLAST 17.522879 Scm SAM domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  3.32682088990761 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.30659353957398 bayes_pls_golite062009
  • DNA binding
    		•  2.70497733333132 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.37622955739691 bayes_pls_golite062009
  • transcription factor activity
    		•  2.23426547892206 bayes_pls_golite062009
  • protein binding
    		•  2.12913758162323 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.70062739321673 bayes_pls_golite062009
  • chromatin binding
    		•  0.807569304631599 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.407335178205755 bayes_pls_golite062009
  • catalytic activity
    		•  0.0451617952658021 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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