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View Structure Prediction Details

Protein: Scm-PA, FBpp0297150
Organism: Drosophila melanogaster
Length: 877 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Scm-PA, FBpp0297150.

Description E-value Query
Range
Subject
Range
gi|52078435, gi|... - gi|52078435|gb|AAH82309.1| L3mbtl3 protein [Mus musculus], gi|111598650|gb|AAH85192.1| L3mbtl3 prote...
576.0 [0..31] [874..57]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGGRDSSTS SGSNSAAPGA STNATSSASA SASSTSTSAS PGSTTSPAST QRQRGRPAKR  60
   61 ATCTWCGEGK LPLQYVLPTQ TGKKEFCSET CIAEFRKAYS KGACTQCDNV IRDGAPNKEF 120
  121 CSIMCMNKHQ KKNCSTRHSG GSASGKGLAE SERKLLAS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.64
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #2
Region A:
Residues: [159-382]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAPAPTGPFQ YESFHVFDWD AYLEETGSEA APAKCFKQAQ NPPNNDFKIG MKLEALDPRN  60
   61 VTSTCIATVV GVLGSRLRLR LDGSDSQNDF WRLVDSTEIH AIGHCEKNGG MLQPPLGFRM 120
  121 NASSWPGYLC KILNNAMVAP EEIFQPEPPE PEENLFKVGQ KLEAVDKKNP QLICCATVDA 180
  181 IKDDQIHVTF DGWRGAFDYW CNYRSRDIFP AGWCARSCHP MQPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 93.045757
Match: 2bivA
Description: CRYSTAL STRUCTURE OF THE WILD-TYPE MBT DOMAINS OF HUMAN SCML2
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [383-547]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GHKSRMDSSS SKQRCPRPRY TVVAESEAMV PASPATAHFH PNCKGGPFIN NSKLPCMVTG  60
   61 PTYQTLAKLC LQEVLAASTD TQQLSKLLFA LEGDVHIVTA AGKNFTVKIP SPMRMKDDES 120
  121 LAQFIETLCT TCRACANLIS LVHETEECKK CANSRKRQLT QSATP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [548-801]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSSPVLADKR NRQSNSATTS PSEKIIKQEL AVKSPVESKS KTSTNNGKEP ASQQNSNHSL  60
   61 NNNNNSASKS SNKVVIKSEP NGANAQTSST TQALRKVRFQ HHANTNTNSS ATNGNQDTSQ 120
  121 TTHVSTSHCS SSSTSSSTSL AGGSANTSTI GKYLAPLVAE VHPEQANVKP SNSYYKSPTT 180
  181 LSSSASLPTS VSTPFTGCQS ASSTALAAGG VTAAKAATAP AGAAATAGAS PSYTAITSPV 240
  241 STPTSALANS HLRS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [802-877]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPIDWTIEEV IQYIESNDNS LAVHGDLFRK HEIDGKALLL LNSEMMMKYM GLKLGPALKI  60
   61 CNLVNKVNGR RNNLAL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.522879
Match: 1pk3A
Description: Scm SAM domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.32682088990761 bayes_pls_golite062009
transcription regulator activity 3.30659353957398 bayes_pls_golite062009
DNA binding 2.70497733333132 bayes_pls_golite062009
nucleic acid binding 2.37622955739691 bayes_pls_golite062009
transcription factor activity 2.23426547892206 bayes_pls_golite062009
protein binding 2.12913758162323 bayes_pls_golite062009
transcription repressor activity 1.70062739321673 bayes_pls_golite062009
chromatin binding 0.807569304631599 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.407335178205755 bayes_pls_golite062009
catalytic activity 0.0451617952658021 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle