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Protein Overview: FBpp0306685, Crc-PA

General Information:
Name(s) found: FBpp0306685 [FlyBase]
Crc-PA / FBpp0081581 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • type=protein; loc=3R:complement(5454783..5455337,5455430..5455902,5456171..5456275,5456400..5456487); ID=FBpp0306685; name=Crc-PB; parent=FBgn0005585,FBtr0334618; dbxref=FlyBase:FBpp0306685,FlyBase_Annotation_IDs:CG9429-PB,REFSEQ:NP_001262430,GB_protein:AGB95812; MD5=eabaa92be574c66ba639d00e53c2fba9; length=406; release=r5.56; species=Dmel; [FlyBase]
  • The gene Calreticulin is referred to in FlyBase by the symbol Dmel\Crc (CG9429, FBgn0005585). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5454660..5456607. It has the cytological map location 85E1. Based on sequence similarity, it is predicted to have molecular function</span>: calcium ion binding. There is experimental evidence that it is involved in the biological process</span>: central nervous system development; startle response; brain morphogenesis; olfactory behavior; locomotion involved in locomotory behavior. 37 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; embryonic peripheral nervous system. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 406 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDA]
    endoplasmic reticulum lumen [ISS][NAS]
    Biological Process: locomotion involved in locomotory behavior [IMP]
    central nervous system development [IMP]
    startle response [IMP]
    peripheral nervous system development [TAS]
    brain morphogenesis [IMP]
    olfactory behavior [IMP]
    protein folding [IEA]
    Molecular Function: calcium ion binding [ISS][NAS]
    unfolded protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMWCKTVIVL LATVGFISAE VYLKENFDNE NWEDTWIYSK HPGKEFGKFV LTPGTFYNDA  60
   61 EADKGIQTSQ DARFYAASRK FDGFSNEDKP LVVQFSVKHE QNIDCGGGYV KLFDCSLDQT 120
  121 DMHGESPYEI MFGPDICGPG TKKVHVIFSY KGKNHLISKD IRCKDDVYTH FYTLIVRPDN 180
  181 TYEVLIDNEK VESGNLEDDW DFLAPKKIKD PTATKPEDWD DRATIPDPDD KKPEDWDKPE 240
  241 HIPDPDATKP EDWDDEMDGE WEPPMIDNPE FKGEWQPKQL DNPNYKGAWE HPEIANPEYV 300
  301 PDDKLYLRKE ICTLGFDLWQ VKSGTIFDNV LITDDVELAA KAAAEVKNTQ AGEKKMKEAQ 360
  361 DEVQRKKDEE EAKKASDKDD EDEDDDDEEK DDESKQDKDQ SEHDEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..406] PSI-BLAST 121.0 Calnexin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  2.94586353433162 bayes_pls_golite062009
  • binding
    		•  2.22628447073433 bayes_pls_golite062009
  • protein binding
    		•  1.59690189281529 bayes_pls_golite062009
  • integrin binding
    		•  0.44914470874038 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.315905766704983 bayes_pls_golite062009
  • protein complex binding
    		•  0.283682917345071 bayes_pls_golite062009
  • complement component C1q binding
    		•  0.263125963729881 bayes_pls_golite062009
  • ion binding
    		•  0.222418863848902 bayes_pls_golite062009
  • cation binding
    		•  0.211029876587877 bayes_pls_golite062009
  • metal ion binding
    		•  0.211029876587877 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.138676484096114 bayes_pls_golite062009
  • calcium ion binding
    		•  0.0419680638917248 bayes_pls_golite062009
  • chaperone binding
    		•  0.0327049405271921 bayes_pls_golite062009
  • receptor binding
    		•  0.00136269572479586 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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