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Protein Overview: sage-PB

General Information:
Name(s) found: sage-PB / FBpp0081463 [FlyBase]
Description(s) found:
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  • gi|24645293|ref|NP_731326.1| salivary gland-expressed bHLH, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|23170777|gb|AAN13413.1| salivary gland-expressed bHLH, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene salivary gland-expressed bHLH is referred to in FlyBase by the symbol Dmel\sage (CG12952, FBgn0037672). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5088383..5089464. It has the cytological map location 85D7. There is experimental evidence that it has the molecular function</span>: transcription regulator activity. There is experimental evidence that it is involved in the biological process</span>: regulation of gene-specific transcription from RNA polymerase II promoter. 5 alleles are reported. The phenotype of these alleles is annotated with: embryonic/larval salivary gland. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG12952-PB translation from_gene[CG12952 sage FBgn0037672] seq_release:3 mol_weight=19747 cds_boundaries:(3R:5,088,616..5,089,210[-]) aa_length:178 transcript_info:[CG12952-RB seq_release:3] gene_info:[gene symbol:sage FBgn0037672 gene_boundaries:(3R: [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q8INP5) CG12952-PB [DrosMelano7227.FASTAC.txt]
  • CG12952-PB, isoform B [Drosophila melanogaster]gi|24645293|ref|NP_731326.1| CG12952-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(5088597..5088735,5088797..5089194); ID=FBpp0081463; name=sage-PB; parent=FBgn0037672,FBtr0081983; dbxref=FlyBase:FBpp0081463,FlyBase_Annotation_IDs:CG12952-PB,GB_protein:AAN13413.1,REFSEQ:NP_731326,GB_protein:AAN13413; MD5= [fly-100309-contam.fasta]
  • salivary gland-expressed bHLH CG12952-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG12952-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(5088597..5088735,5088797..5089194); ID=FBpp0081463; name=sage-PB; parent=FBgn0037672,FBtr0081983; dbxref=FlyBase:FBpp0081463,FlyBase_Annotation_IDs:CG12952-PB,GB_protein:AAN13413.1,REFSEQ:NP_731326,GB_protein:AAN13413; MD5=b2c0dccd2964139d6307256717869b51; length=178; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(5088597..5088735,5088797..5089194); ID=FBpp0081463; name=sage-PB; parent=FBgn0037672,FBtr0081983; dbxref=FlyBase:FBpp0081463,FlyBase_Annotation_IDs:CG12952-PB,GB_protein:AAN13413.1,REFSEQ:NP_731326,GB_protein:AAN13413; MD5=b2c0dccd2964139d6307256717869b51; length=178; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Salivary gland-expressed bHLH, isoform B OS=Drosophila melanogaster GN=sage PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(5088597..5088735,5088797..5089194); ID=FBpp0081463; name=sage-PB; parent=FBgn0037672,FBtr0081983; dbxref=FlyBase:FBpp0081463,FlyBase_Annotation_IDs:CG12952-PB,GB_protein:AAN13413.1,REFSEQ:NP_731326,GB_protein:AAN13413,FlyMine:FBpp0081463,modMine:FBpp0081463; MD5=b2c0dccd2964139d6307256717869b51; length=178; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
    • Organism: Drosophila melanogaster
    Length: 178 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][IEA]
    Biological Process: regulation of transcription [IEA][ISS]
    regulation of gene-specific transcription from RNA polymerase II promoter [IDA]
    Molecular Function: transcription factor activity [ISS]
    transcription regulator activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGYEKEAHN MGLLPPTYSV IPQPVSMWHA GQVATGSPVG LECNKPSELV PPPMYMSYSG  60
   61 GSIANSTEVD IAKEHNPAWR EKALQMEKDY RRTACDRERT RMRDMNRAFD LLRSKLPISK 120
  121 PNGKKYSKIE SLRIAINYIN HLQAMLRESS VGQNGNGCCA WSGGSSSPYD NGNDHWGA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..83] deduced N/A No confident structure predictions are available.
    2 View Details [84..178] PSI-BLAST 13.30103 SREBP-1a

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.38658950816179 bayes_pls_golite062009
  • DNA binding
    		•  5.18654839258297 bayes_pls_golite062009
  • transcription factor activity
    		•  4.78039531631248 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.75270293029792 bayes_pls_golite062009
  • binding
    		•  3.81829206350975 bayes_pls_golite062009
  • transcription factor binding
    		•  2.61163564741984 bayes_pls_golite062009
  • transcription activator activity
    		•  2.5495467409976 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.48787404513864 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.31910036997977 bayes_pls_golite062009
  • protein binding
    		•  1.59929864805879 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.52770895937238 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  1.46304579811572 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.955588849035129 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.801830750183111 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.3513586903977 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle