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Protein Overview: Tcp-1eta-PA

General Information:
Name(s) found: Tcp-1eta-PA / FBpp0081401 [FlyBase]
Description(s) found:
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  • gi|24645179|ref|NP_649835.1| Tcp-1eta [Drosophila melanogaster] [NCBI NR]
  • gi|23170738|gb|AAF54292.2| Tcp-1eta [Drosophila melanogaster] [NCBI NR]
  • gi|21483476|gb|AAM52713.1| LD47396p [Drosophila melanogaster] [NCBI NR]
  • The gene Tcp-1Ã?&#142;Ã?· is referred to in FlyBase by the symbol Dmel\Tcp-1Ã?&#142;Ã?· (CG8351, FBgn0037632). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:4627275..4631958. It has the cytological map location 85B1-85B2. Based on sequence similarity, it is predicted to have molecular function</span>: ATPase activity, coupled. There is experimental evidence that it is involved in the biological process</span>: mitotic spindle organization. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG8351-PA translation from_gene[CG8351 CG8351 FBgn0037632] seq_release:3 mol_weight=59387 cds_boundaries:(3R:4,627,415..4,631,753[+]) aa_length:544 transcript_info:[CG8351-RA seq_release:3] gene_info:[gene symbol:CG8351 FBgn0037632 gene_boundaries:(3R [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VHL2) CG8351 protein (LD47396p) [DrosMelano7227.FASTAC.txt]
  • CG8351-PA [Drosophila melanogaster]gi|21483476|gb|AAM52713.1| LD47396p [Drosophila melanogaster]gi|24645179|ref|NP_649835.1| CG8351-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(4627400..4627402,4627581..4627841,4627908..4628727,4628801..4629124,4631515..4631741); ID=FBpp0081401; name=Tcp-1eta-PA; parent=FBgn0037632,FBtr0081918; dbxref=FlyBase:FBpp0081401,FlyBase_Annotation_IDs:CG8351-PA,GB_protein:AAF54 [fly-100309-contam.fasta]
  • CG8351-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • LD47396p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(4627400..4627402,4627581..4627841,4627908..4628727,4628801..4629124,4631515..4631741); ID=FBpp0081401; name=Tcp-1eta-PA; parent=FBgn0037632,FBtr0081918; dbxref=FlyBase:FBpp0081401,FlyBase_Annotation_IDs:CG8351-PA,GB_protein:AAF54292.2,REFSEQ:NP_649835,GB_protein:AAF54292; MD5=9582736c3c6587027daf68554b2c3f0c; length=544; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(4627400..4627402,4627581..4627841,4627908..4628727,4628801..4629124,4631515..4631741); ID=FBpp0081401; name=Tcp-1eta-PA; parent=FBgn0037632,FBtr0081918; dbxref=FlyBase:FBpp0081401,FlyBase_Annotation_IDs:CG8351-PA,GB_protein:AAF54292.2,REFSEQ:NP_649835,GB_protein:AAF54292; MD5=9582736c3c6587027daf68554b2c3f0c; length=544; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • LD47396p OS=Drosophila melanogaster GN=Tcp-1eta PE=2 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:join(4627400..4627402,4627581..4627841,4627908..4628727,4628801..4629124,4631515..4631741); ID=FBpp0081401; name=Tcp-1eta-PA; parent=FBgn0037632,FBtr0081918; dbxref=FlyBase:FBpp0081401,FlyBase_Annotation_IDs:CG8351-PA,GB_protein:AAF54292.2,REFSEQ:NP_649835,GB_protein:AAF54292,FlyMine:FBpp0081401,modMine:FBpp0081401; MD5=9582736c3c6587027daf68554b2c3f0c; length=544; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(8801678..8801680,8801859..8802119,8802186..8803005,8803079..8803402,8805793..8806019); ID=FBpp0081401; name=Tcp-1eta-PA; parent=FBgn0037632,FBtr0081918; dbxref=FlyBase:FBpp0081401,FlyBase_Annotation_IDs:CG8351-PA,GB_protein:AAF54292.2,REFSEQ:NP_649835,GB_protein:AAF54292,FlyMine:FBpp0081401,modMine:FBpp0081401; MD5=9582736c3c6587027daf68554b2c3f0c; length=544; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(8801678..8801680,8801859..8802119,8802186..8803005,8803079..8803402,8805793..8806019); ID=FBpp0081401; name=Tcp-1eta-PA; parent=FBgn0037632,FBtr0081918; dbxref=FlyBase:FBpp0081401,FlyBase_Annotation_IDs:CG8351-PA,GB_protein:AAF54292.2,REFSEQ:NP_649835,GB_protein:AAF54292,FlyMine:FBpp0081401,modMine:FBpp0081401; MD5=9582736c3c6587027daf68554b2c3f0c; length=544; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • LD47396p OS=Drosophila melanogaster GN=Tcp-1eta PE=1 SV=2 [DROME.fasta.20160308]
  • FBpp0081401 type=protein; loc=3R:join(8801678..8801680,8801859..8802119,8802186..8803005,8803079..8803402,8805793..8806019); ID=FBpp0081401; name=Tcp-1eta-PA; parent=FBgn0037632,FBtr0081918; dbxref=FlyBase:FBpp0081401,FlyBase_Annotation_IDs:CG8351-PA,GB_protein:AAF54292.2,REFSEQ:NP_649835,GB_protein:AAF54292,FlyMine:FBpp0081401,modMine:FBpp0081401; MD5=9582736c3c6587027daf68554b2c3f0c; length=544; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(8801678..8801680,8801859..8802119,8802186..8803005,8803079..8803402,8805793..8806019); ID=FBpp0081401; name=CCT7-PA; parent=FBgn0037632,FBtr0081918; dbxref=FlyBase:FBpp0081401,FlyBase_Annotation_IDs:CG8351-PA,GB_protein:AAF54292.2,REFSEQ:NP_649835,GB_protein:AAF54292,UniProt/TrEMBL:Q9VHL2,FlyMine:FBpp0081401,modMine:FBpp0081401; MD5=9582736c3c6587027daf68554b2c3f0c; length=544; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 544 amino acids

    Gene Ontology:
    Cellular Component: chaperonin-containing T-complex [ISS]
    Biological Process: mitotic spindle organization [IMP]
    protein folding [ISS]
    Molecular Function: ATP binding [IEA]
    unfolded protein binding [IEA]
    ATPase activity, coupled [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPQIVLLKE GTDSSQGKPQ LVSNINACQS IVDAVRTTLG PRGMDKLIVD AHGKATISND  60
   61 GATIMKLLEI IHPAAKTLVD IAKSQDAEVG DGTTSVVLLA GEFLKQVKPF VEEGVHPRVI 120
  121 IKAIRKALQL CMEKINEMAV QIVEQSKDQQ RALLEKCAAT AMSSKLIHQQ KDFFSRIVVD 180
  181 AVLSLDELLP LNMIGIKKVT GGSLEESQLV SGVAFKKTFS YAGFEMAPKS YDNCKIALLN 240
  241 IELELKAERD NAEIRVDNVK EYQKVVDAEW QILYNKLAKI HESGANVVLS KLPIGDVATQ 300
  301 YFADRDIFCA GRVPEEDLKR TMKACGGAVM TTANDIKPNV LGLCEHFEER QVGGERFNLF 360
  361 QGCPNAKTST LILRGGAEQF LEETERSLHD AIMIVRRTIK HDSVVAGGGA IEMELSKLLR 420
  421 DYSRTIAGKE QLLIAAIAKG LEIIPRQLCD NAGFDATNIL NKLRQKHAQG GQWYGVDINK 480
  481 EDISDNYEQC VWEPSIIKIN ALTAAAEAAC MILSVDETIK SPKAGEPPMA GGGMGMGRGM 540
  541 GRPM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..544] PSI-BLAST 135.0 Crystal structure of the chaperonin from Thermococcus strain KS-1 (nucleotide-free form of single mutant)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  7.60116801069598 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.6934849790316 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  3.40373598585301 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  3.28982639907979 bayes_pls_golite062009
  • binding
    		•  2.07154556649829 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.67284737458957 bayes_pls_golite062009
  • DNA binding
    		•  1.60256620441721 bayes_pls_golite062009
  • transporter activity
    		•  1.27879339110564 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08697283907212 bayes_pls_golite062009
  • chaperone binding
    		•  0.91200031047441 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.828920415160435 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.787685249362834 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.75018875403424 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.69634667457441 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.682843768728088 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.680378643689288 bayes_pls_golite062009
  • protein binding
    		•  0.634982583867058 bayes_pls_golite062009
  • ATPase activity
    		•  0.584574936611857 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.573106450426516 bayes_pls_golite062009
  • catalytic activity
    		•  0.424959044318554 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.280310103153739 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.275534581026027 bayes_pls_golite062009
  • hydrogen-exporting ATPase activity, phosphorylative mechanism
    		•  0.26275673855778 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.252704226951294 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.243984617084631 bayes_pls_golite062009
  • misfolded protein binding
    		•  0.20601711041274 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.205808843369749 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.202279803135899 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.20198255686005 bayes_pls_golite062009
  • transferase activity
    		•  0.18639662517366 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.16424934648837 bayes_pls_golite062009
  • kinase activity
    		•  0.0871496920547826 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0778814959589007 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0491351110520448 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle