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Protein Overview: zen-PA

General Information:
Name(s) found: zen-PA / FBpp0081170 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • The gene zerknullt is referred to in FlyBase by the symbol Dmel\zen (CG1046, FBgn0004053). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2578586..2582059. It has the cytological map location 84A5. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding; specific transcriptional repressor activity. There is experimental evidence that it is involved in the biological process</span>: compound eye development. 27 alleles are reported. The phenotypes of these alleles are annotated with: embryonic optic lobe primordium; embryonic head; cuticle; extended germ band embryo; optic lobe; embryonic central nervous system; denticle belt. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 353 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: dorsal/ventral pattern formation, imaginal disc [NAS]
    amnioserosa formation [TAS]
    regulation of transcription, DNA-dependent [IEA]
    dorsal/ventral axis specification [TAS]
    regulation of transcription [IEA]
    compound eye development [IMP]
    Molecular Function: transcription factor activity [IEA]
    specific RNA polymerase II transcription factor activity [ISS]
    sequence-specific DNA binding [IDA]
    specific transcriptional repressor activity [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSVMHYYPV HQAKVGSYSA DPSEVKYSDL IYGHHHDVNP IGLPPNYNQM NSNPTTLNDH  60
   61 CSPQHVHQQH VSSDENLPSQ PNHDSQRVKL KRSRTAFTSV QLVELENEFK SNMYLYRTRR 120
  121 IEIAQRLSLC ERQVKIWFQN RRMKFKKDIQ GHREPKSNAK LAQPQAEQSA HRGIVKRLMS 180
  181 YSQDPREGTA AAEKRPMMAV APVNPKPDYQ ASQKMKTEAS TNNGMCSSAD LSEILEHLAQ 240
  241 TTAAPQVSTA TSSTGTSTNS ASSSSSGHYS YNVDLVLQSI KQDLEAAAQA WSKSKSAPIL 300
  301 ATQSWHPSSQ SQVPTSVHAA PSMNLSWGEP AAKSRKLSVN HMNPCVTSYN YPN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..157] PSI-BLAST 20.69897 Paired protein
    2 View Details [158..353] MSA 13.734997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  1.04132983826241 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle