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Protein Overview: Hcs-PA

General Information:
Name(s) found: Hcs-PA / FBpp0078332 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Holocarboxylase synthetase is referred to in FlyBase by the symbol Dmel\Hcs (CG14670, FBgn0037332). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1300624..1311115. It has the cytological map location 83A5. Based on sequence similarity, it is predicted to have molecular function</span>: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity. There is experimental evidence that it is involved in the biological process</span>: response to heat. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1041 amino acids

    Gene Ontology:
    Cellular Component: polytene chromosome [IDA]
    Biological Process: response to heat [IMP]
    protein modification process [IEA]
    Molecular Function: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity [ISS]
    biotin-[acetyl-CoA-carboxylase] ligase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLTLYYVSAT VLQSWRIQKA CSKIAEHLAQ PSSIAFYTLQ SGSDDGFDPA LASSELCCNR  60
   61 NAAKVTDILW LHANQRGCCL RPLQTLHITP WISFPPAPSL LPFSYAADTL TPASTPTEAD 120
  121 VPRQQRVSLS AQGEERMQLL LEADIEPLQR PSSEDTSAVR LEDYGKLIAW KIDSHLAVLI 180
  181 ETDVEHFTKL LITTFLRNNL CINDQLPLLR IESVQREGDP QPFELLAKHL KRQSRISVGL 240
  241 DKDGWKKHME DLRAVGVLAH QATEFEYQRN RSEGRTKSDP TTHDQRPTSE LLAKAVAVVE 300
  301 PTNKAYLSPA RTTEASLKAE AKGTSTKPFP TKSDAKPATL AKSEGTPATS KEDSKLTPTK 360
  361 GALKTSELEK LAAVQAAQQQ KKEAVQVSPV KAAFLAKPPM LSKHDEPDKA SDQPTKPRKS 420
  421 FEAVKPLNSP PSSRAAPSRP VLQRNKDSLQ DAKPLNVLVY SDSASAREST LATLQQLLER 480
  481 NVYTIYPLMP QQAAQKYWTE QTALLVVCGS VAHGIGQILV DYFLQGGKVL SLCSDILHFV 540
  541 LPNYRTAEVR EHELVQFSYD KWQRVKMMHH IFCYQPSPVK KHFSTDSEES TKSHSRKPSM 600
  601 ELKDLAGHSH NLDVHVLGTE ETWNTPSLML AKSLQSGGKA VFSQVHLEMN PSEFESDETK 660
  661 YSILKQNERT RLEIFADLLG KYLDVQVRGG DGVDQPQPGV VYKHAYFLGR HEAKFELLEK 720
  721 LRLRCSGSDN VIATPNLTMK FCGKDDKPPV ANNNVLPILI HSCPDDFSTV DYFDNLKTEH 780
  781 IGRLVIYAPV VSSSMHLINN LELIHGLAVL PVQQTSGVGR RNNQWLSPPG CAMFSLQLHL 840
  841 TMDSALSSRL PLLQHLVGTA IVNSLRSHEE YGVLDISIKW PNDIYANGNQ KIGGLVINTT 900
  901 LQGSQAIVNI GSGINLNNSR PTVCINDLIR EYNTRVPNNK LPILKYELLI AMIFNEIERL 960
  961 LGEVQNGDFD SFYALYYSLW LHSGQSVKIC LQKDQEKEAE IVGIDDFGFL EVKLPTGTIE1020
 1021 IVQPDGNSFD MLKGLIIPKY Q

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..150] deduced N/A No confident structure predictions are available.
    2 View Details [151..393] MSA 4.284997 View MSA. No confident structure predictions are available.
    3 View Details [394..512] MSA 1.266994 View MSA. No confident structure predictions are available.
    4 View Details [513..707] deduced N/A No confident structure predictions are available.
    5 View Details [708..1041] PSI-BLAST 85.09691 THE E. COLI BIOTIN HOLOENZYME SYNTHETASE(SLASH)BIO REPRESSOR CRYSTAL STRUCTURE DELINEATES THE BIOTIN AND DNA-BINDING DOMAINS

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • aminoacyl-tRNA ligase activity
    		•  4.025601351766 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  4.02412423650651 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  4.02412423650651 bayes_pls_golite062009
  • ligase activity
    		•  3.51191116674556 bayes_pls_golite062009
  • catalytic activity
    		•  1.99372273395202 bayes_pls_golite062009
  • phenylalanine-tRNA ligase activity
    		•  0.685157827624735 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.66129822977065 bayes_pls_golite062009
  • binding
    		•  0.521863822270226 bayes_pls_golite062009
  • transcription activator activity
    		•  0.5042529875675 bayes_pls_golite062009
  • structural molecule activity
    		•  0.272316540117209 bayes_pls_golite062009
  • ATP binding
    		•  0.18403217430648 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.145955341735342 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  0.134313783036163 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  0.133891091298639 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.127823774098159 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.0912115683429473 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  0.0218173339521677 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle