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Protein Overview: 5-HT2-PB

General Information:
Name(s) found: 5-HT2-PB / FBpp0078495 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Serotonin receptor 2 is referred to in FlyBase by the symbol Dmel\5-HT2 (CG1056, FBgn0087012). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:438597..459026. It has the cytological map location 82C3-82D5. Based on sequence similarity, it is predicted to have molecular function</span>: G-protein coupled amine receptor activity; G-protein coupled serotonin receptor activity. There is experimental evidence that it is involved in the biological process</span>: germ-band extension. 13 alleles are reported. The phenotypes of these alleles are annotated with: gastrula embryo; extended germ band embryo; pole cell; embryonic epidermis; ventral midline; denticle belt. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 930 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEA][ISS]
    plasma membrane [IDA][ISS][NAS]
    Biological Process: G-protein coupled receptor protein signaling pathway [IEA]
    germ-band extension [IMP]
    serotonin receptor signaling pathway [ISS][NAS][TAS]
    Molecular Function: 5-HT2 receptor activity [NAS]
    G-protein coupled serotonin receptor activity [ISS]
    serotonin receptor activity [NAS][TAS]
    G-protein coupled amine receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEMQSYSGRG PSTGTSETAT ATAAVASASA SDTAATFTLR HFNCRLEEAD WPGPRQPFID  60
   61 CEGSHTNSTS YTPSSLPTSK NLIEGPNNTF QCARQAIDEA EHNAFYSCDG ESPLSENCTL 120
  121 RLKARLLRWP YEAYEHIRLA INGALSDYAS DKLSDSSSCD EGGMVLQCKL GQAHELLLCH 180
  181 LQQLEREPLR EVGSAEESFS NDSLLQAFQI ELGAERDGLW SFLNLSELME PDHGFLGIMN 240
  241 VTNTSLDMFL PNLTALNTTS TASTADMATE FAVTKSFLDY SPHGYDFLFL FVVFFIFAGG 300
  301 LGNILVCLAV ALDRKLQNVT NYFLFSLAIA DLLVSLFVMP MGAIPAFLGY WPLGFTWCNI 360
  361 YVTCDVLACS SSILHMCFIS LGRYMGIRNP LGSRHRSTKR LTGIKIAIVW VMAMMVSSSI 420
  421 TVLGLVNEKN IMPEPNICVI NNRAFFVFGS LVAFYIPMLM MVTTYALTIP LLRKKARFAA 480
  481 EHPESELFRR LGGRFTLRPQ HSQQQLQMFS SFSGSNNKFL SMGDGNRNFN TEGEMEEGGA 540
  541 PSRRSGVEPA ERPLMQQRTA SSRSMGTVSF RNVVNGTSGA AGSGRRTTGT AHSSFRFSGA 600
  601 GIFRHSSSSP ASSCHSTSTS RSSSFWRKHG GYPNLMDRLA IHLRLSLVPP SSHPNRRASV 660
  661 RVTISQPQLG YPTNVGGNGG RTVGATEVGA GGNGSSAGRT SNSSLGGTSL MKIATIQGPI 720
  721 LNQSQAAGGN HMVQKVKPTA LKPEEPQRNK VRPFKFAFNR VATPTLNLRF LNNRSKRNSL 780
  781 SANAVATEQK ATKVLGLVFF TFVLCWSPFF ILNIIFAACP ECQVPEHVVN TCLWLGYVSS 840
  841 TINPIIYTIF NRTFRAAFIR LLKCNCKRSG RPLRYRSVTE GRGALSLCAP SALPLAISFQ 900
  901 GAPLMTPSTA NATPMSEFRA SCRTVTDDEC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..249] deduced N/A No confident structure predictions are available.
    2 View Details [250..532] PSI-BLAST 37.0 Rhodopsin
    3 View Details [533..930] FFAS03 4.44 Rhodopsin


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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