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View Structure Prediction Details

Protein: 5-HT2-PB
Organism: Drosophila melanogaster
Length: 930 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for 5-HT2-PB.

Description E-value Query
Range
Subject
Range
5-HT2-PA - The gene Serotonin receptor 2 is referred to in FlyBase by the symbol Dmel\5-HT2 (CG1056, FBgn008701...
740.0 [0..1] [868..1]

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Predicted Domain #1
Region A:
Residues: [1-249]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEMQSYSGRG PSTGTSETAT ATAAVASASA SDTAATFTLR HFNCRLEEAD WPGPRQPFID  60
   61 CEGSHTNSTS YTPSSLPTSK NLIEGPNNTF QCARQAIDEA EHNAFYSCDG ESPLSENCTL 120
  121 RLKARLLRWP YEAYEHIRLA INGALSDYAS DKLSDSSSCD EGGMVLQCKL GQAHELLLCH 180
  181 LQQLEREPLR EVGSAEESFS NDSLLQAFQI ELGAERDGLW SFLNLSELME PDHGFLGIMN 240
  241 VTNTSLDMF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [250-532]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPNLTALNTT STASTADMAT EFAVTKSFLD YSPHGYDFLF LFVVFFIFAG GLGNILVCLA  60
   61 VALDRKLQNV TNYFLFSLAI ADLLVSLFVM PMGAIPAFLG YWPLGFTWCN IYVTCDVLAC 120
  121 SSSILHMCFI SLGRYMGIRN PLGSRHRSTK RLTGIKIAIV WVMAMMVSSS ITVLGLVNEK 180
  181 NIMPEPNICV INNRAFFVFG SLVAFYIPML MMVTTYALTI PLLRKKARFA AEHPESELFR 240
  241 RLGGRFTLRP QHSQQQLQMF SSFSGSNNKF LSMGDGNRNF NTE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.0
Match: 1f88A
Description: Rhodopsin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [533-930]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEMEEGGAPS RRSGVEPAER PLMQQRTASS RSMGTVSFRN VVNGTSGAAG SGRRTTGTAH  60
   61 SSFRFSGAGI FRHSSSSPAS SCHSTSTSRS SSFWRKHGGY PNLMDRLAIH LRLSLVPPSS 120
  121 HPNRRASVRV TISQPQLGYP TNVGGNGGRT VGATEVGAGG NGSSAGRTSN SSLGGTSLMK 180
  181 IATIQGPILN QSQAAGGNHM VQKVKPTALK PEEPQRNKVR PFKFAFNRVA TPTLNLRFLN 240
  241 NRSKRNSLSA NAVATEQKAT KVLGLVFFTF VLCWSPFFIL NIIFAACPEC QVPEHVVNTC 300
  301 LWLGYVSSTI NPIIYTIFNR TFRAAFIRLL KCNCKRSGRP LRYRSVTEGR GALSLCAPSA 360
  361 LPLAISFQGA PLMTPSTANA TPMSEFRASC RTVTDDEC

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.44
Match: 1f88A
Description: Rhodopsin
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle