Protein Overview: skd-PD, skd-PC

General Information:
Name(s) found:	skd-PC / FBpp0077985 [FlyBase] skd-PD / FBpp0077984 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|74876666\|sp\|Q7KTX8.1\|MED13_DROME RecName: Full=Mediator of RNA polymerase II transcription subunit 13; AltName: Full=Mediator complex subunit 13; AltName: Full=Mediator complex subunit Skuld; AltName: Full=Protein blind spot; AltName: Full=Protein poil [NCBI NR] gi\|7239301\|gb\|AAF43172.1\| jlkjlkj [Drosophila melanogaster] [NCBI NR] gi\|7230590\|gb\|AAF43021.1\|AF227214_1 Pap/DTRAP240 [Drosophila melanogaster] [NCBI NR] gi\|7109237\|gb\|AAF36691.1\| TRAP240 [Drosophila melanogaster] [NCBI NR] gi\|24667811\|ref\|NP_730590.1\| skuld, isoform C [Drosophila melanogaster] [NCBI NR] gi\|23094200\|gb\|AAN12149.1\| skuld, isoform D [Drosophila melanogaster] [NCBI NR] gi\|23094199\|gb\|AAN12148.1\| skuld, isoform C [Drosophila melanogaster] [NCBI NR] gi\|17864210\|ref\|NP_524653.1\| skuld, isoform D [Drosophila melanogaster] [NCBI NR] gi\|12060982\|gb\|AAG48327.1\|AF324425_1 transcriptional coactivator blind spot [Drosophila melanogaster] [NCBI NR] Mediator of RNA polymerase II transcription subunit 13 OS=Drosophila melanogaster GN=skd PE=1 SV=1 [Swiss-Prot] The gene skuld is referred to in FlyBase by the symbol Dmel\skd (CG9936, FBgn0003415). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:20987228..21020524. It has the cytological map location 78A2. There is experimental evidence that it has the molecular function</span>: protein binding; RNA polymerase II transcription mediator activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of Wnt receptor signaling pathway; sex comb development; wing disc dorsal/ventral pattern formation; regulation of transcription from RNA polymerase II promoter; embryonic development; cell fate commitment. 44 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; eye disc; mitotic cell cycle; antennal disc; photoreceptor cell; crystal cell; larval mouth. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] >CG9936-PD translation from_gene[CG9936 pap FBgn0024200] seq_release:3 mol_weight=280026 cds_boundaries:(3L:20,912,983..20,942,296[-]) aa_length:2618 transcript_info:[CG9936-RD seq_release:3] gene_info:[gene symbol:pap FBgn0024200 gene_boundaries:(3L:2 [hmr_yeast5_DM3-1_pombe.fasta] >CG9936-PC translation from_gene[CG9936 pap FBgn0024200] seq_release:3 mol_weight=280026 cds_boundaries:(3L:20,912,983..20,942,296[-]) aa_length:2618 transcript_info:[CG9936-RC seq_release:3] gene_info:[gene symbol:pap FBgn0024200 gene_boundaries:(3L:2 [hmr_yeast5_DM3-1_pombe.fasta] >CG9936-PB translation from_gene[CG9936 pap FBgn0024200] seq_release:3 mol_weight=280026 cds_boundaries:(3L:20,912,983..20,942,296[-]) aa_length:2618 transcript_info:[CG9936-RB seq_release:3] gene_info:[gene symbol:pap FBgn0024200 gene_boundaries:(3L:2 [hmr_yeast5_DM3-1_pombe.fasta] (AAN12148) CG9936-PC [DrosMelano7227.FASTAC.txt] CG9936-PD, isoform D [Drosophila melanogaster]gi\|23094199\|gb\|AAN12148.1\| CG9936-PC, isoform C [Drosophila melanogaster]gi\|7239301\|gb\|AAF43172.1\| jlkjlkj [Drosophila melanogaster]gi\|7230590\|gb\|AAF43021.1\| Pap/DTRAP240 [Drosophila melanogaster]gi\|710923 [nrdb_11152004_Chlamydomonas] type=protein; loc=3L:complement(20988804..20989187,20989249..20989364,20989424..20989538,20989602..20994381,20994443..20995026,20995117..20995297,20998078..20998762,20998832..20999280,20999657..20999740,20999808..20999901,21005311..21005626,21018052..2101 [fly-100309-contam.fasta] skuld CG9936-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] TRAP240 [Drosophila melanogaster] [nr-271106-contam.fasta] Pap/DTRAP240 [Drosophila melanogaster] [nr-271106-contam.fasta] CG9936-PD, isoform D [Drosophila melanogaster] [nr-271106-contam.fasta] CG9936-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] skuld CG9936-PD, isoform D [Drosophila melanogaster] [nr-271106-contam.fasta] jlkjlkj [Drosophila melanogaster] [nr-271106-contam.fasta] transcriptional coactivator blind spot [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3L:complement(20988804..20989187,20989249..20989364,20989424..20989538,20989602..20994381,20994443..20995026,20995117..20995297,20998078..20998762,20998832..20999280,20999657..20999740,20999808..20999901,21005311..21005626,21018052..21018120); ID=FBpp0077985; name=skd-PC; parent=FBgn0003415,FBtr0078329; dbxref=FlyBase:FBpp0077985,FlyBase_Annotation_IDs:CG9936-PC,GB_protein:AAN12148.1,REFSEQ:NP_730590,GB_protein:AAN12148; MD5=8de3326b740ac68cc1062b4a1c763ad3; length=2618; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3L:complement(20988804..20989187,20989249..20989364,20989424..20989538,20989602..20994381,20994443..20995026,20995117..20995297,20998078..20998762,20998832..20999280,20999657..20999740,20999808..20999901,21005311..21005626,21018052..21018120); ID=FBpp0077984; name=skd-PD; parent=FBgn0003415,FBtr0078328; dbxref=FlyBase:FBpp0077984,FlyBase_Annotation_IDs:CG9936-PD,GB_protein:AAN12149.1,REFSEQ:NP_524653,GB_protein:AAN12149; MD5=8de3326b740ac68cc1062b4a1c763ad3; length=2618; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3L:complement(20988804..20989187,20989249..20989364,20989424..20989538,20989602..20994381,20994443..20995026,20995117..20995297,20998078..20998762,20998832..20999280,20999657..20999740,20999808..20999901,21005311..21005626,21018052..21018120); ID=FBpp0077985; name=skd-PC; parent=FBgn0003415,FBtr0078329; dbxref=FlyBase:FBpp0077985,FlyBase_Annotation_IDs:CG9936-PC,GB_protein:AAN12148.1,REFSEQ:NP_730590,GB_protein:AAN12148; MD5=8de3326b740ac68cc1062b4a1c763ad3; length=2618; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=3L:complement(20988804..20989187,20989249..20989364,20989424..20989538,20989602..20994381,20994443..20995026,20995117..20995297,20998078..20998762,20998832..20999280,20999657..20999740,20999808..20999901,21005311..21005626,21018052..21018120); ID=FBpp0077984; name=skd-PD; parent=FBgn0003415,FBtr0078328; dbxref=FlyBase:FBpp0077984,FlyBase_Annotation_IDs:CG9936-PD,GB_protein:AAN12149.1,REFSEQ:NP_524653,GB_protein:AAN12149; MD5=8de3326b740ac68cc1062b4a1c763ad3; length=2618; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] LD48112p OS=Drosophila melanogaster GN=skd-RC PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=3L:complement(20988804..20989187,20989249..20989364,20989424..20989538,20989602..20994381,20994443..20995026,20995117..20995297,20998078..20998762,20998832..20999280,20999657..20999740,20999808..20999901,21005311..21005626,21018052..21018120); ID=FBpp0077985; name=skd-PC; parent=FBgn0003415,FBtr0078329; dbxref=FlyBase:FBpp0077985,FlyBase_Annotation_IDs:CG9936-PC,GB_protein:AAN12148.1,REFSEQ:NP_730590,GB_protein:AAN12148,FlyMine:FBpp0077985,modMine:FBpp0077985; MD5=8de3326b740ac68cc1062b4a1c763ad3; length=2618; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3L:complement(20988804..20989187,20989249..20989364,20989424..20989538,20989602..20994381,20994443..20995026,20995117..20995297,20998078..20998762,20998832..20999280,20999657..20999740,20999808..20999901,21005311..21005626,21018052..21018120); ID=FBpp0077984; name=skd-PD; parent=FBgn0003415,FBtr0078328; dbxref=FlyBase:FBpp0077984,FlyBase_Annotation_IDs:CG9936-PD,GB_protein:AAN12149.1,REFSEQ:NP_524653,GB_protein:AAN12149; MD5=8de3326b740ac68cc1062b4a1c763ad3; length=2618; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3L:complement(join(21024952..21025020,21012211..21012526,21006708..21006801,21006557..21006640,21005732..21006180,21004978..21005662,21002017..21002197,21001343..21001926,20996502..21001281,20996324..20996438,20996149..20996264,20995704..20996087)); ID=FBpp0077985; name=skd-PC; parent=FBgn0003415,FBtr0078329; dbxref=FlyBase:FBpp0077985,FlyBase_Annotation_IDs:CG9936-PC,GB_protein:AAN12148.1,REFSEQ:NP_730590,GB_protein:AAN12148,FlyMine:FBpp0077985,modMine:FBpp0077985; MD5=8de3326b740ac68cc1062b4a1c763ad3; length=2618; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3L:complement(join(21024952..21025020,21012211..21012526,21006708..21006801,21006557..21006640,21005732..21006180,21004978..21005662,21002017..21002197,21001343..21001926,20996502..21001281,20996324..20996438,20996149..20996264,20995704..20996087)); ID=FBpp0077984; name=skd-PD; parent=FBgn0003415,FBtr0078328; dbxref=FlyBase:FBpp0077984,FlyBase_Annotation_IDs:CG9936-PD,GB_protein:AAN12149.1,REFSEQ:NP_524653,GB_protein:AAN12149; MD5=8de3326b740ac68cc1062b4a1c763ad3; length=2618; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3L:complement(join(21024952..21025020,21012211..21012526,21006708..21006801,21006557..21006640,21005732..21006180,21004978..21005662,21002017..21002197,21001343..21001926,20996502..21001281,20996324..20996438,20996149..20996264,20995704..20996087)); ID=FBpp0077985; name=skd-PC; parent=FBgn0003415,FBtr0078329; dbxref=FlyBase:FBpp0077985,FlyBase_Annotation_IDs:CG9936-PC,GB_protein:AAN12148.1,REFSEQ:NP_730590,GB_protein:AAN12148,FlyMine:FBpp0077985,modMine:FBpp0077985; MD5=8de3326b740ac68cc1062b4a1c763ad3; length=2618; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=3L:complement(join(21024952..21025020,21012211..21012526,21006708..21006801,21006557..21006640,21005732..21006180,21004978..21005662,21002017..21002197,21001343..21001926,20996502..21001281,20996324..20996438,20996149..20996264,20995704..20996087)); ID=FBpp0077984; name=skd-PD; parent=FBgn0003415,FBtr0078328; dbxref=FlyBase:FBpp0077984,FlyBase_Annotation_IDs:CG9936-PD,GB_protein:AAN12149.1,REFSEQ:NP_524653,GB_protein:AAN12149; MD5=8de3326b740ac68cc1062b4a1c763ad3; length=2618; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0077985 type=protein; loc=3L:complement(join(21024952..21025020,21012211..21012526,21006708..21006801,21006557..21006640,21005732..21006180,21004978..21005662,21002017..21002197,21001343..21001926,20996502..21001281,20996324..20996438,20996149..20996264,20995704..20996087)); ID=FBpp0077985; name=skd-PC; parent=FBgn0003415,FBtr0078329; dbxref=FlyBase:FBpp0077985,FlyBase_Annotation_IDs:CG9936-PC,GB_protein:AAN12148.1,REFSEQ:NP_730590,GB_protein:AAN12148,FlyMine:FBpp0077985,modMine:FBpp0077985; MD5=8de3326b740ac68cc1062b4a1c763ad3; length=2618; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0077984 type=protein; loc=3L:complement(join(21024952..21025020,21012211..21012526,21006708..21006801,21006557..21006640,21005732..21006180,21004978..21005662,21002017..21002197,21001343..21001926,20996502..21001281,20996324..20996438,20996149..20996264,20995704..20996087)); ID=FBpp0077984; name=skd-PD; parent=FBgn0003415,FBtr0078328; dbxref=FlyBase:FBpp0077984,FlyBase_Annotation_IDs:CG9936-PD,GB_protein:AAN12149.1,REFSEQ:NP_524653,GB_protein:AAN12149; MD5=8de3326b740ac68cc1062b4a1c763ad3; length=2618; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3L:complement(join(21024952..21025020,21012211..21012526,21006708..21006801,21006557..21006640,21005732..21006180,21004978..21005662,21002017..21002197,21001343..21001926,20996502..21001281,20996324..20996438,20996149..20996264,20995704..20996087)); ID=FBpp0077985; name=skd-PC; parent=FBgn0003415,FBtr0078329; dbxref=FlyBase:FBpp0077985,FlyBase_Annotation_IDs:CG9936-PC,GB_protein:AAN12148.1,REFSEQ:NP_730590,GB_protein:AAN12148,UniProt/Swiss-Prot:Q7KTX8,FlyMine:FBpp0077985,modMine:FBpp0077985; MD5=8de3326b740ac68cc1062b4a1c763ad3; length=2618; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=3L:complement(join(21024952..21025020,21012211..21012526,21006708..21006801,21006557..21006640,21005732..21006180,21004978..21005662,21002017..21002197,21001343..21001926,20996502..21001281,20996324..20996438,20996149..20996264,20995704..20996087)); ID=FBpp0077984; name=skd-PD; parent=FBgn0003415,FBtr0078328; dbxref=FlyBase:FBpp0077984,FlyBase_Annotation_IDs:CG9936-PD,GB_protein:AAN12149.1,REFSEQ:NP_524653,GB_protein:AAN12149,UniProt/Swiss-Prot:Q7KTX8; MD5=8de3326b740ac68cc1062b4a1c763ad3; length=2618; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	2618 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] mediator complex [IDA][ISS][NAS]
Biological Process:	embryonic development [IMP] cell fate commitment [IGI] transcription from RNA polymerase II promoter [NAS] wing disc dorsal/ventral pattern formation [IGI] sex comb development [IGI][IMP] positive regulation of Wnt receptor signaling pathway [IMP] transcription initiation from RNA polymerase II promoter [ISS] regulation of transcription from RNA polymerase II promoter [IDA]
Molecular Function:	protein binding [IPI] [NOT]serine-type endopeptidase activity [NAS] RNA polymerase II transcription mediator activity [IDA][ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTHQNHQTNG ASLEDCHTNF YALTDLCGIK WRKFVNGERP NASSDPLADP ILRSYSRCIQ  60
   61 ADMLCVWRRV QSTKTDHADP NALTFEMTTS TKVHPPLSLA AAKELWIFWY GEEPDLSELV 120
  121 DAELLRVAAN QALWNGTWKG ALTYECRSLL FKALHNLMER FVLTKDIVRF GKWFVQPCTS 180
  181 SDRLFGRSSQ HLSFSFTFFV HGDTVCASID LREHPAVRPL TKEHLTEAAA AFAAASSPPG 240
  241 SNGSAASAGG AVPNPGQDPN GASMDGLDGG EGAAKAAPPP HARKVMLAPF GIAGILTGNS 300
  301 YKASDPIAEK ILEDWASFFP LCNKDNTDVP PVVEVVSGGH KMYHPTNYVL VTDLDDMEHM 360
  361 EFVEMQKMQS SVAGAAAESA VLASLSCPPG AASAPSSMGA APSATAVPLG PASLNAPALA 420
  421 GAGVGATASS AAKEISRKAA PQAVSALERL AFQPYYDQRP TSGFTFNTNN THIPASAAVE 480
  481 MPERTWQDCV MNTLHVDAAA AAAAVASSTP ASGTGSLSAD GDENEQNKPP QDSKQLVQQQ 540
  541 IQQQQQRQKL WNFVDPMQKA PCICTKHLGN TPHGTPHGGA STYSRNSLGG DSSMPVASVE 600
  601 SPATPAPSPH PNSAHSQPTS VPPAEQLLNM SPHAPTSVSN LQQPPTPIDH LLDKNTPAPT 660
  661 PTDQHDSKSI TASPYVHQTP SVEPPSYTDH AAGGGPAGGQ GLGTGPGSVP AQQPATPTAA 720
  721 TSAGGAGSGG PSNAIGANAV GTISVKKLEM QQQTPSAAMA IKQEPGAQGR GVGGVTSTTE 780
  781 ALNNFKRLYN PPKLTLKDPD SFYDEEWLKE VIYDFQYQEY WDYSTVKRPK MEKQRRPRYA 840
  841 KNLYEGQNHV KPVMPSPGSV YGSQLLSLDE SASQAGGRGG GGQAAGSSGG GLVGIANSTA 900
  901 SGSDVEADGS SFFQGLNIKT EPGLHSPSCK ETSKSSGGNS SGGGSGSGGN LFTAEGLNPS 960
  961 LNDLEQLFET SSNDECSSVQ IHTPPDSNNP SNGGCSAVTN TIEDLKRSTA VASAAVAAAA1020
 1021 AAAASGAGNI QAEDLTKMFP TPPSHEQQHP NSSPCQTDVV MTDLSVDTTT TIITSSITTT1080
 1081 CNTTITSSIN TTTTACSNPS NSIMLAAAQA PVTVVAIQTV SKMVKQEYNL ELGSPMEEPI1140
 1141 NDWDYVYRPP QQEKFVGSTR YAPLTNLPSQ TQPPLTLPTG CFYQPTWSSH KSRAATLAKA1200
 1201 AAAQQQQHQK HQALQQRIQL HQQKLQQLQL QNQQQQQAAA AAAAAASGGV GHQKHQHQHL1260
 1261 HDLLSAAPRT PLTPSTVPQP LSSGGSQYLL NQLNCPQAPP GASMQQLMHR AGMSPISPGP1320
 1321 GMGPYAARSS PMSRATPTHP PPPYPYDLAV ASPATSTSSY LNRPLHSQEH PHMHGLGGGA1380
 1381 TGVVGHGTGG GGHMGMVAYT GDAGIVSGGT AMAAGSSSLL QELPEVNSVL VNILLYDTAL1440
 1441 NVFRDHNFDS SSVCVCNADT QKIGNIRGAD SGVYVPLPGV SFNPFPSGAG GALAGQRMLN1500
 1501 GPSSAGFGGM RMISAFGGSP ASASMPGAGS GHGHGPNGGS NSSSCTPPSS NPHITGYVDD1560
 1561 DPVECTCGFS AVVNRRLSHR AGLFYEDEVE ITGIADDPGR NKQPTLLSII QSLSRKNQNK1620
 1621 QGPGETSSAL DKIGAGGLPN GQLEQLGHAV FDLLLDQCSI IQTSSSSVHR ALQSHRRRMS1680
 1681 RQRRIFGNNG APTASLASIA NVLEFMDAHD VISLALEQSR LAFENQRMDN MMDFHGNGSS1740
 1741 SSHQQQQLTA FHAPPPALRH KLAGIGAGRL TVHKWPYLPV GFTRSNKEIV RTMNAIQPML1800
 1801 QNAFHCKSRG GSGSKDASSY NTVSGPLTWR QFHRLAGRAS GQCEPQPIPS VVVGYEKDWI1860
 1861 SVAPHSIHYW DKFLLEPYSY ARDVVYVVVC PDNEHVVNCT RSYFRELSST YEMCKLGKHT1920
 1921 PIRGWDGFLQ VGAARNNVPA DRETTPLDDW LRTLEHAALA EQIRRYAVAF IHQLAPYLSR1980
 1981 VPNDKTLLNP PDGSGNSHSK GGSSCSSNSS SVSGLPGGDL PTDNIKLEPG TEPQVQPMET2040
 2041 NEIKQEPGVG KGGTAAGETK PTLILGDPLG MGETLEDINP SAIVLYVVNP FTFASDSCEL2100
 2101 ERLALIALLR CYAELLKAVP DSVRSQMNIQ IISLESVMEL GPCGNRKRFS DEIRCLALNI2160
 2161 FSQCRRHLVH AQSVKSLTGF GTAANMEAFL KTKDEPNRRA YKMYTAPFVL APMHERNDKT2220
 2221 DFSRSAGSMH GQNEHRYSVM YCNYCLSEDQ AWLLATATDE RGEMLEKICI NIDVPNRARR2280
 2281 RKAPARYVAL KKLMDFIMGI ISQTSQMWRL VIGRIGRIGH SELKSWSFLL SKQQLQKASK2340
 2341 QFKDMCKQCT LMYPPTILSA CLVTLEPDAK LRVMPDQFTP DERFSQISMQ NPLATPQDVT2400
 2401 CTHILVFPTS AVCAPFTRQF QNEPQVDDDF LTFEEEGNED FSDADIGDLF WDTHMDRVSN2460
 2461 HGSPGRMDDN RSWQSAGGNN FKCTPPQEVE EVGSLNQQPI SVGYMVSTAP TGRMPAWFWS2520
 2521 ACPHLEDVCP VFLKTALHLH VPSIQSADDI LNSTNAHQSG NDHPLDSNLT ADVLRFVLEG2580
 2581 YNALSWLALD SNTHDRLSCL PINVQTLMDL YYLTAAIA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.80

Protein Overview: skd-PD, skd-PC

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: