Protein Overview: Nedd4-PJ

General Information:
Name(s) found:	Nedd4-PJ / FBpp0289746 [FlyBase]
Description(s) found: Found 22 descriptions. SHOW ALL	The gene Nedd4 is referred to in FlyBase by the symbol Dmel\Nedd4 (CG42279, FBgn0259174). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:17523183..17539760. It has the cytological map location 74D3. There is experimental evidence that it has the molecular function</span>: Notch binding; protein binding; protein domain specific binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of Notch signaling pathway; receptor internalization; positive regulation of receptor internalization; axon guidance; positive regulation of synaptogenesis; positive regulation of endocytosis; axon midline choice point recognition; protein ubiquitination. 43 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; wing vein L3; posterior commissure; anterior crossvein; longitudinal connective; embryonic central nervous system; wing; wing vein; anterior commissure. It has 7 annotated transcripts and 7 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1007 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	positive regulation of receptor internalization [IMP] positive regulation of endocytosis [IMP] axon guidance [IMP] axon midline choice point recognition [IMP] negative regulation of Notch signaling pathway [IGI][IMP] positive regulation of synaptogenesis [IMP] receptor internalization [IMP][IPI] protein ubiquitination [IDA][IMP]
Molecular Function:	ubiquitin-protein ligase activity [ISS] protein domain specific binding [IDA][IPI] protein binding [IPI] Notch binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSARSSGLVA AAALPVPSSS SSVAGGDVPR PPPRRRAASV AGQQQTRQEF GNGYTPRRSL  60
   61 AAVNDSGDSC HLRIVVLTGQ SLAKKDIFGA SDPYVRIDLN TINGDINIDS VLTKTKKKTL 120
  121 NPTWNEEFIF RVKPSEHKLV FQVFDENRLT RDDFLGMVEL TLVNLPTEQE GRTIGEQSYT 180
  181 LRPRRSVGAK SRIKGTLRIY HAFIRETREQ SEPSSGNSDG EWEHVEATNA GETSAQPHPF 240
  241 PTGGHDALPA GWEERQDANG RTYYVNHTAR TTQWDRPTVL NSHSSQSTDD QLASDFQRRF 300
  301 HISVDDTESG RSADSISHNS IEDNNNAAGL AYTPKTAATS SAPPNTPTNN NGILAQIAMQ 360
  361 YRAEEDQDPT VDHTSFVYNS LRHPVAHRQP EISATSLQND LRPVREAPGV PDIAITNPFT 420
  421 RRAAGNMAGG AGWQQERRRQ QMQLHIQQHQ QRQQQQQQNR ILLDVDHRQQ EPQHRGQRHQ 480
  481 QQHRPSNEDT DHTDSHNPSD ISAPSTRRNS EEDNAAVPPM EQNTGGEEEP LPPRWSMQVA 540
  541 PNGRTFFIDH ASRRTTWIDP RNGRASPMPN QTRRVEDDLG PLPEGWEERV HTDGRVFYID 600
  601 HNTRTTQWED PRLSNPNIAG QAVPYSRDYK QKYEYFKSHI RKPTNVPNKF EIRIRRTSIL 660
  661 EDSYRIISSV TKTDLLKTKL WVEFEGETGL DYGGLAREWF YLLSKEMFNP YYGLFEYSAM 720
  721 DNYTLQINNG SGLCNEEHLS YFKFIGRIAG MAVYHGKLLD AFFIRPFYKM MLQKPIDLKD 780
  781 MESVDTEYYN SLMWIKENDP RILELTFCLD EDVFGQKSQH ELKPGGANID VTNENKDEYI 840
  841 KLVIEWRFVA RVKEQMSSFL DGFGSIIPLN LIKIFDEHEL ELLMCGIQNI DVKDWRENTL 900
  901 YKGDYHMNHI IIQWFWRAVL SFSNEMRSRL LQFVTGTSRV PMNGFKELYG SNGPQMFTIE 960
  961 KWGTPNNFPR AHTCFNRLDL PPYEGYLQLK DKLIKAIEGS QGFAGVD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: Nedd4-PJ

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: