Protein Overview: Nrx-IV-PA

General Information:
Name(s) found:	Nrx-IV-PA / FBpp0075730 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7294612\|gb\|AAF49951.1\| neurexin IV, isoform A [Drosophila melanogaster] [NCBI NR] gi\|24663169\|ref\|NP_524034.2\| neurexin IV, isoform A [Drosophila melanogaster] [NCBI NR] gi\|17433136\|sp\|Q94887.2\|NRX4_DROME RecName: Full=Neurexin-4; AltName: Full=Neurexin IV; Flags: Precursor [NCBI NR] Neurexin-4 OS=Drosophila melanogaster GN=Nrx-IV PE=1 SV=2 [Swiss-Prot] The gene Neurexin IV is referred to in FlyBase by the symbol Dmel\Nrx-IV (CG6827, FBgn0013997). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:12139675..12150106. It has the cytological map location 68F6-68F7. Based on sequence similarity, it is predicted to have molecular function</span>: transmembrane receptor activity. There is experimental evidence that it is involved in the biological process</span>: dorsal closure; nerve maturation; regulation of tube size, open tracheal system; establishment of glial blood-brain barrier; septate junction assembly; axon ensheathment. 28 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; nervous system; peripheral nervous system; adult segment; thoracic segment; adult mesothoracic segment; embryonic dorsal trunk; embryonic tracheal system; multi-cell-component structure; external compound sense organ; neuromuscular junction; plasma membrane part. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] >CG6827-PA translation from_gene[CG6827 Nrx FBgn0013997] seq_release:3 mol_weight=145469 cds_boundaries:(3L:12,104,402..12,113,785[+]) aa_length:1284 transcript_info:[CG6827-RA seq_release:3] gene_info:[gene symbol:Nrx FBgn0013997 gene_boundaries:(3L:1 [hmr_yeast5_DM3-1_pombe.fasta] (Q94887) Neurexin IV precursor [DrosMelano7227.FASTAC.txt] (AE003542) Nrx gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG6827-PA, isoform A [Drosophila melanogaster]gi\|24663169\|ref\|NP_524034.2\| CG6827-PA [Drosophila melanogaster]gi\|17433136\|sp\|Q94887\|NRX4_DROME Neurexin IV precursor [nrdb_11152004_Chlamydomonas] type=protein; loc=3L:join(12139955..12140060,12141892..12142008,12144920..12145116,12145277..12145418,12145480..12146658,12146723..12146848,12147051..12147254,12147314..12148243,12148303..12148482,12148546..12148890,12148955..12149092,12149151..12149341); [fly-100309-contam.fasta] Neurexin-4 precursor (Neurexin IV) [nr-271106-contam.fasta] CG6827-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] Neurexin IV CG6827-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3L:join(12139955..12140060,12141892..12142008,12144920..12145116,12145277..12145418,12145480..12146658,12146723..12146848,12147051..12147254,12147314..12148243,12148303..12148482,12148546..12148890,12148955..12149092,12149151..12149341); ID=FBpp0075730; name=Nrx-IV-PA; parent=FBgn0013997,FBtr0075998; dbxref=FlyBase:FBpp0075730,FlyBase_Annotation_IDs:CG6827-PA,GB_protein:AAF49951.1,REFSEQ:NP_524034,GB_protein:AAF49951; MD5=bb9d2b0def2cd839cd217b45b6d7152f; length=1284; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3L:join(12139955..12140060,12141892..12142008,12144920..12145116,12145277..12145418,12145480..12146658,12146723..12146848,12147051..12147254,12147314..12148243,12148303..12148482,12148546..12148890,12148955..12149092,12149151..12149341); ID=FBpp0075730; name=Nrx-IV-PA; parent=FBgn0013997,FBtr0075998; dbxref=FlyBase:FBpp0075730,FlyBase_Annotation_IDs:CG6827-PA,GB_protein:AAF49951.1,REFSEQ:NP_524034,GB_protein:AAF49951; MD5=bb9d2b0def2cd839cd217b45b6d7152f; length=1284; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=3L:join(12139955..12140060,12141892..12142008,12144920..12145116,12145277..12145418,12145480..12146658,12146723..12146848,12147051..12147254,12147314..12148243,12148303..12148482,12148546..12148890,12148955..12149092,12149151..12149341); ID=FBpp0075730; name=Nrx-IV-PA; parent=FBgn0013997,FBtr0075998; dbxref=FlyBase:FBpp0075730,FlyBase_Annotation_IDs:CG6827-PA,GB_protein:AAF49951.1,REFSEQ:NP_524034,GB_protein:AAF49951,FlyMine:FBpp0075730,modMine:FBpp0075730; MD5=bb9d2b0def2cd839cd217b45b6d7152f; length=1284; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3L:join(12146855..12146960,12148792..12148908,12151820..12152016,12152177..12152318,12152380..12153558,12153623..12153748,12153951..12154154,12154214..12155143,12155203..12155382,12155446..12155790,12155855..12155992,12156051..12156241); ID=FBpp0075730; name=Nrx-IV-PA; parent=FBgn0013997,FBtr0075998; dbxref=FlyBase:FBpp0075730,FlyBase_Annotation_IDs:CG6827-PA,GB_protein:AAF49951.1,REFSEQ:NP_524034,GB_protein:AAF49951,FlyMine:FBpp0075730,modMine:FBpp0075730; MD5=bb9d2b0def2cd839cd217b45b6d7152f; length=1284; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3L:join(12146855..12146960,12148792..12148908,12151820..12152016,12152177..12152318,12152380..12153558,12153623..12153748,12153951..12154154,12154214..12155143,12155203..12155382,12155446..12155790,12155855..12155992,12156051..12156241); ID=FBpp0075730; name=Nrx-IV-PA; parent=FBgn0013997,FBtr0075998; dbxref=FlyBase:FBpp0075730,FlyBase_Annotation_IDs:CG6827-PA,GB_protein:AAF49951.1,REFSEQ:NP_524034,GB_protein:AAF49951,FlyMine:FBpp0075730,modMine:FBpp0075730; MD5=bb9d2b0def2cd839cd217b45b6d7152f; length=1284; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0075730 type=protein; loc=3L:join(12146855..12146960,12148792..12148908,12151820..12152016,12152177..12152318,12152380..12153558,12153623..12153748,12153951..12154154,12154214..12155143,12155203..12155382,12155446..12155790,12155855..12155992,12156051..12156241); ID=FBpp0075730; name=Nrx-IV-PA; parent=FBgn0013997,FBtr0075998; dbxref=FlyBase:FBpp0075730,FlyBase_Annotation_IDs:CG6827-PA,GB_protein:AAF49951.1,REFSEQ:NP_524034,GB_protein:AAF49951,FlyMine:FBpp0075730,modMine:FBpp0075730; MD5=bb9d2b0def2cd839cd217b45b6d7152f; length=1284; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3L:join(12146855..12146960,12148792..12148908,12151820..12152016,12152177..12152318,12152380..12153558,12153623..12153748,12153951..12154154,12154214..12155143,12155203..12155382,12155446..12155790,12155855..12155992,12156051..12156241); ID=FBpp0075730; name=Nrx-IV-PA; parent=FBgn0013997,FBtr0075998; dbxref=FlyBase:FBpp0075730,FlyBase_Annotation_IDs:CG6827-PA,GB_protein:AAF49951.1,REFSEQ:NP_524034,GB_protein:AAF49951,UniProt/Swiss-Prot:Q94887,FlyMine:FBpp0075730,modMine:FBpp0075730; MD5=bb9d2b0def2cd839cd217b45b6d7152f; length=1284; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1284 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [NAS] septate junction [NAS][TAS] integral to membrane [NAS] pleated septate junction [IDA] plasma membrane [ISS]
Biological Process:	dorsal closure [IMP][NAS][TAS] regulation of tube size, open tracheal system [IMP] establishment of blood-nerve barrier [NAS] establishment or maintenance of cell polarity [NAS] protein localization [TAS] cell adhesion [IEA] establishment of glial blood-brain barrier [IMP] axon ensheathment [IMP] cell-cell junction organization [TAS] synaptic vesicle targeting [NAS] synaptic vesicle docking during exocytosis [NAS] nerve maturation [IMP] septate junction assembly [IMP][NAS]
Molecular Function:	transmembrane receptor activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRPPRSNTKA AFSSLQFGLL CLLLLVNNGI KSVQADAFTD YFSDYDCNQP LMERAVLTAT  60
   61 SSLTERGPDK ARLNGNAAWT PVENTYNHFL TLDLGDPRMV RKIATMGRMH TDEFVTEYIV 120
  121 QYSDDGEFWR SYVNPTSEPQ MFKGNSDGNS IHYNVFEVPI IAQWVRINPT RWHDRISMRV 180
  181 ELYGCDYISE NLYFNGTGLV RYDLRREPIT STKESIRFRF KTAFANGVMM YSRGTQGDYY 240
  241 ALQLKDNKMV LNLDLGSRVM TSLSVGSLLD DNVWHDVVIS RNQRDIIFSV DRVIVRGRIQ 300
  301 GEFTRLNLNR ELYLGGVPNV QEGLIVQQNF SGCLENIYFN STNFIRVMKD STELGEGYLF 360
  361 TRVNTIYACP SPPIYPVTFT TRSSFVRLKG YENSQRLNVS FYFRTYEETG VMLHHDFYSG 420
  421 GYLKVFLEFG KVKIDLKVKD KARIILDNYD DQFNDGKWHS FVISIEKNRL ILNIDQRPMT 480
  481 TTKSMQVATG AQYYIAGGKD KNGFVGCMRL ISVDGNYKLP QDWVKGEEVC CGDDVVVDAC 540
  541 QMIDRCNPNP CQHKGLCHQN SREFFCDCGH TGYAGAVCHT SNNPLSCLAL KNVQHVQQRV 600
  601 NLNLDVDGSG PLEPFPVTCE FYSDGRVITT LSHSQEHTTT VDGFQEPGSF EQSIMYDANQ 660
  661 LQIEALLNRS HSCWQRLSYS CRSSRLFNSP SEAGNFRPFS WWISRHNQPM DYWAGALPGS 720
  721 RKCECGILGK CHDPTKWCNC DSNSLEWMED GGDIREKEYL PVRAVKFGDT GTPLDEKMGR 780
  781 YTLGPLRCEG DDLFSNVVTF RIADASINLP PFDMGHSGDI YLEFRTTQEN SVIFHATGPT 840
  841 DYIKLSLNGG NKLQFQYQAG SGPLGVNVGT SYHLNDNNWH TVSVERNRKE ARLVVDGSIK 900
  901 AEVREPPGPV RALHLTSDLV IGATTEYRDG YVGCIRALLL NGKMVDLKEY SKRGLYGIST 960
  961 GCVGRCESNP CLNNGTCIER YDGYSCDCRW SAFKGPICAD EIGVNLRSSS IIRYEFEGSF1020
 1021 RSTIAENIRV GFTTTIPKGF LLGFSSNLTG EYLTIQISNS GHLRCVFDFG FERQEIIFPK1080
 1081 KHFGLGQYHD MHFMRKNGGS TVVLKVDNYE PVEYNFDIKA SADAQFNNIQ YMYIGKNESM1140
 1141 TDGFVGCVSR VQFDDIYPLK LMFQQNPPKN VKSLGTQLTE DFCGVEPVTH PPIEIETRPP1200
 1201 PLVDEEKLRK AYNEVDSVLL ACLLVILFLL LILMFFLIGR YLHRHKGDYL THEDQGADGA1260
 1261 DDPDDAVLHS TTGHQVRKRT EIFI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: Nrx-IV-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: