YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: Nelf-E-PA

General Information:
Name(s) found: Nelf-E-PA / FBpp0076374 [FlyBase]
Description(s) found:
Found 26 descriptions.
SHOW ALL
  • The gene Negative elongation factor E is referred to in FlyBase by the symbol Dmel\Nelf-E (CG5994, FBgn0017430). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:8592542..8593974. It has the cytological map location 66D8. There is experimental evidence that it has the molecular function</span>: mRNA binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of transcription from RNA polymerase II promoter, mitotic. 6 alleles are reported. The phenotypes of these alleles are annotated with: antennal segment 2; adult thorax; adult head; tarsal segment; wing; arista; ommatidium; antennal segment 3. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 280 amino acids

    Gene Ontology:
    Cellular Component: transcriptional repressor complex [IDA]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter, mitotic [IDA]
    Molecular Function: nucleotide binding [IEA]
    mRNA binding [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVYIHFPNNL TEEEQMLQAK YQKLKKKKKA LQAHKAPKPE PESSLTLKRP TDARDAREVA  60
   61 RKLIKSGAIP AIQKQTKQDQ TSFKRPKGQE RAKRSTSETT VASYQPFSST QNDVAQETII 120
  121 SEIIKEEPRR QNLYQHFATE RDREERGMPE KVPMDTAQPE KPRAGNTIFV SGNKVTEDFL 180
  181 KKTFNDYGTI VNVSMEIEKS RGFVSFAKPE SADRAIAEIH GKNVNGINLQ VQLARRQPQI 240
  241 EPINDASSSA VWSSIAASKS QKGSHKDHRE MVQYDEDFLL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..280] PSI-BLAST 15.69897 No description for 2ghpA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleic acid binding
    		•  4.92126426323641 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • RNA binding
    		•  2.92438188845619 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.18211199677674 bayes_pls_golite062009
  • DNA binding
    		•  1.98418556946403 bayes_pls_golite062009
  • mRNA binding
    		•  1.94495589345842 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.25394600300835 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.1920664543285 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • transcription factor activity
    		•  1.07843408116687 bayes_pls_golite062009
    		• 0.84116054461637 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.632534695085793 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.383589644462932 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle