Protein Overview: sfl-PB, sfl-PA

General Information:
Name(s) found:	sfl-PB / FBpp0290777 [FlyBase] sfl-PA / FBpp0076677 [FlyBase]
Description(s) found: Found 33 descriptions. SHOW ALL	The gene sulfateless is referred to in FlyBase by the symbol Dmel\sfl (CG8339, FBgn0020251). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:6488780..6542333. It has the cytological map location 65B3-65B4. There is experimental evidence that it has the molecular function</span>: [heparan sulfate]-glucosamine N-sulfotransferase activity. There is experimental evidence that it is involved in the biological process</span>: fibroblast growth factor receptor signaling pathway; glycosaminoglycan biosynthetic process; mesoderm migration; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; sulfur metabolic process; Wnt receptor signaling pathway; segment polarity determination; epithelial cell migration, open tracheal system. 16 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; embryonic/larval tracheal system; cuticle; portion of tissue; tracheal system; integumentary system; nervous system; embryonic nervous system; midgut constriction; primordium; peripheral nervous system. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] The gene sulfateless is referred to in FlyBase by the symbol Dmel\sfl (CG8339, FBgn0020251). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:6488780..6542333. It has the cytological map location 65B3-65B4. There is experimental evidence that it has the molecular function</span>: [heparan sulfate]-glucosamine N-sulfotransferase activity. There is experimental evidence that it is involved in the biological process</span>: fibroblast growth factor receptor signaling pathway; glycosaminoglycan biosynthetic process; mesoderm migration; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; sulfur metabolic process; Wnt receptor signaling pathway; segment polarity determination; epithelial cell migration, open tracheal system. 16 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; embryonic/larval tracheal system; cuticle; portion of tissue; tracheal system; integumentary system; nervous system; embryonic nervous system; midgut constriction; primordium; peripheral nervous system. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1048 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	heart development [NAS] epithelial cell migration, open tracheal system [IGI][IMP][TAS] heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [IMP][NAS] primary branching, open tracheal system [TAS] sulfur metabolic process [IMP] heparan sulfate proteoglycan biosynthetic process [NAS][TAS] mesoderm migration [IMP][TAS] glycosaminoglycan biosynthetic process [IMP] segment polarity determination [IMP] fibroblast growth factor receptor signaling pathway [IGI][IMP][TAS] Wnt receptor signaling pathway [IMP] cell surface receptor linked signaling pathway [NAS]
Molecular Function:	[heparan sulfate]-glucosamine N-sulfotransferase activity [IMP][ISS][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTISGGNQHN NNANRKYEKL IKQPQMQFGS SVTGTQTDVD SCRDADADAN AVRQDFSNFN  60
   61 KHFGNGHAIT DRTMLLRLED DVTTAAGIVT YKGKSNGNGN GNGNGSIGSI SLDFNGSPTS 120
  121 STSIGIASGS SSNTHLASGG GVGGIGGSEP AGWMCHCCNL IARRCFGINV RRCVLALLAI 180
  181 TMVSIFYYTH YVDTGVFNGL IQRDTHPAPI INCRMINSGG KHIRNASPAP DHRSEARLRI 240
  241 DPKVLVFVET TYSGLGRDIA ELLVYNRIKY KIEVAGKSLP VLTNLDKGRY GVIVFENLDK 300
  301 YLNMDKWNRE LLDKYCREYS VGIVGFVSPS EETLVGAQLR DFPLFVNTNL RLRDASLNPL 360
  361 SSVLRLTRAG ETAWGALPGD DWAVFQHNHS TYEPVEWAQR NTQEYPADSV GQVQLPLTTV 420
  421 LQDRGQLDGI QRVLFGSSLR FWLHRLVFLD ALSYLSHGQL SLNLERMILV DIDDIFVGEK 480
  481 GTRLRPDDVR ALIATQKNIA AMVPGFRFNL GFSGKYYHHG TREENLGDDF LLQNVQEFNW 540
  541 FSHMWKHQQP HLYDNLTLLM AEMHLNYAFA VDHNIPTDSG YSISPHHSGV YPAHELLYMA 600
  601 WKKVWNVKVT STEEYPHLRP ARLRRGFIHR NIMVLPRQTC GLFTHTMYID RYPGGRDKLD 660
  661 ESIQGGELFQ TIVYNPINIF MTHMSNYGSD RLALYTFQSV IKFLQCWTNL KLASAPPVQL 720
  721 AEMYFRLHPE EVDPVWGNPC DDVRHKKIWS KTKNCDSLPK FLVIGPQKTG TTALYTFLSM 780
  781 HGSIASNIAS PETFEEVQFF NGNNYYRGLD WYMDFFPSES LPNTSSPMPT QLGSPRFMFE 840
  841 KSATYFDGEA VPKRSHALLP HAKIVTILIS PAKRAYSWYQ HQRSHGDVIA NNYSFYQVIT 900
  901 ASDSAPRALK DLRNRCLNPG KYAQHLEHWL AYYPAQQLHI IDGEQLRLNP IDVMNELQRF 960
  961 LKIQPLLDYS NHLRYDVKKG FYCQAVSEKR NKCLGKSKGR QYPAMDERSA KLLQRYYLNH1020
 1021 NTALVKLLKK LGSRPIPQWL KDDLSTGT

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: sfl-PB, sfl-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: