Protein Overview: gek-PA

General Information:
Name(s) found:	gek-PA / FBpp0072194 [FlyBase]
Description(s) found: Found 22 descriptions. SHOW ALL	The gene genghis khan is referred to in FlyBase by the symbol Dmel\gek (CG4012, FBgn0023081). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19979600..19986157. It has the cytological map location 60B9-60B10. There is experimental evidence that it has the molecular function</span>: protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: actin polymerization or depolymerization. 18 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1637 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	intracellular signaling pathway [IEA] actin polymerization or depolymerization [IMP] regulation of actin polymerization or depolymerization [NAS] protein amino acid phosphorylation [IEA][ISS][NAS]
Molecular Function:	ATP binding [IEA] small GTPase regulator activity [IEA] diacylglycerol binding [ISS] protein kinase activity [IDA] protein serine/threonine kinase activity [IEA][ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEYESSEISD ITTGSCKKRL TFLKCILSDT TSDQKWAAEF GEDTEGHQFS LDYLLDTFIV  60
   61 LYDECSNSSL RREKGVSDFL KLSKPFVHIV RKLRLSRDDF DILKIIGRGA FGEVCVVQMI 120
  121 STEKVYAMKI LNKWEMLKRA ETACFREERD VLVFGDRQWI TNLHYAFQDN INLYLVMDYY 180
  181 CGGDLLTLLS KFEDKLPEDM AKFYITEMIL AINSIHQIRY VHRDIKPDNV LLDKRGHVRL 240
  241 ADFGSCLRLD KDGTVQSNVA VGTPDYISPE ILRAMEDGKG RYGTECDWWS LGVCMYEMLY 300
  301 GETPFYAESL VETYGKIMNH QNCFNLPSQE TLNYKVSETS QDLLCKLICI PENRLGQNGI 360
  361 QDFMDHPWFV GIDWKNIRQG PAPYVPEVSS PTDTSNFDVD DNDVRLTDSI PPSANPAFSG 420
  421 FHLPFIGFTF SLTSSSTLDS KKNQSSGFGD DTLDTISSPQ LAILPSNNSE TPVDSVQLKA 480
  481 LNDQLAALKQ EKAELSKQHN EVFERLKTQD SELQDAISQR NIAMMEYSEV TEKLSELRNQ 540
  541 KQKLSRQVRD KEEELDGAMQ KNDSLRNELR KSDKTRRELE LHIEDAVIEA AKEKKLREHA 600
  601 EDCCRQLQME LRKGSSSVET TMPLSISSEM SSYEIERLEL QFSEKLSHQQ TRHNMELEAL 660
  661 REQFSELENA NLALTKELQQ TQERLKYTQM ESITDSAETL LELKKQHDLE KSSWFEEKQR 720
  721 LSSEVNLKSK SLKELQAEDD EIFKELRMKR EAITLWERQM AEIIQWVSDE KDARGYLQAL 780
  781 ATKMTEELEY LKHVGTFNNN GVDNKNWRNR RSQKLDKMEL LNLQSALQRE IQAKNMISDE 840
  841 LSQTRSDLIS TQKEVRDYKK RYDSILHDFQ KKETELRDLQ KGGLEYSESF LNKSTHHGLS 900
  901 SAFFRDMSKN SEIIDSAESF GNESGDNFTP NFFQSGNSGM LFNYEPKYAG KNNKDHSSMK 960
  961 EASVSDLSRE ESDQLVKESQ KKVPGNTAIH QFLVRTFSSP TKCNHCTSLM VGLTRQGVVC1020
 1021 EICGFACHTI CCQKVPTTCP VPMDQTKRPL GIDPTRGIGT AYEGYVKVPK SGVIKRGWIR1080
 1081 QFVVVCDFKL FLYDISPDRC ALPSVSVSQV LDMRDPEFSV GSVRESDVIH AAKKDVPCIF1140
 1141 KIKTALIDGG LSLNTLMLAD NESEKSKWVI ALGELHRILK RNSLPNTAIF KVNEILDNTL1200
 1201 SLIRNALCSV IIYPNQILLG TEDGLFYINL DQYEIARIGE SKKILQLWYI EEEQILVILC1260
 1261 GKQRNLRLLP IRALEASDVE WIKVVESKNC ISACTGIIRR FPNIVYSFII ALKRPNNHTQ1320
 1321 IVVYEINRTR TRHQKTCEFT IGYMAQHLQI LSDMRLVVAH QSGFTAYFLR GEATAMSLVH1380
 1381 PENQLCAFLN YSGVDAVRVI EILCPSGGNF GEYLLVFQTL AIYVDLQGRK SRDREIMYPA1440
 1441 FPTYITFCDG HLLVFSDTHL DIFNTQTAEW VQSIGLKQSL PLNNLGNVVL SSVNDTPLIV1500
 1501 YLSNIHTKGL LQYRDGNRKG LPSIKRRFSI REINKTIKSD RRSKMISAPT NFNHISHMGP1560
 1561 GDGIQNQRLL DLPTTLETAD QACSPIIHSL SCIPQSRKSN FLEQVDANSD DYGNDNIISR1620
 1621 TPSPMASSFM DGLSNND

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	3.46734661087649	bayes_pls_golite062009
transcription regulator activity	2.82097223032126	bayes_pls_golite062009
binding	2.71288992341677	bayes_pls_golite062009
GTPase regulator activity	2.43859890356027	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	2.42148330229896	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.07238897772131	bayes_pls_golite062009
DNA binding	2.05972958088217	bayes_pls_golite062009
kinase activity	2.00903309297046	bayes_pls_golite062009
nucleic acid binding	1.91592331431516	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.83466699022067	bayes_pls_golite062009
enzyme regulator activity	1.78173505822139	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	1.76217210688028	bayes_pls_golite062009
small GTPase regulator activity	1.73820712435638	bayes_pls_golite062009
protein kinase activity	1.61903873760762	bayes_pls_golite062009
transferase activity	1.45394179515146	bayes_pls_golite062009
transcription factor activity	1.38590948364516	bayes_pls_golite062009
signal transducer activity	1.25050856744516	bayes_pls_golite062009
molecular transducer activity	1.25050856744516	bayes_pls_golite062009
protein binding	1.21002143294224	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.969266093401353	bayes_pls_golite062009
protein serine/threonine kinase activity	0.93378879973188	bayes_pls_golite062009
Ras GTPase activator activity	0.854618067843974	bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity	0.716569837044966	bayes_pls_golite062009
GTPase activator activity	0.531562206762648	bayes_pls_golite062009
kinase binding	0.409606963040614	bayes_pls_golite062009
catalytic activity	0.216721136299042	bayes_pls_golite062009
enzyme activator activity	0.160536263083511	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..427]	PSI-BLAST	85.39794	No description for 2f2uA was found.
2	View Details	[428..590]	FFAS03	2.2	Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
3	View Details	[591..980]	PSI-BLAST	11.522879	Heavy meromyosin subfragment
4	View Details	[981..1051]	FFAS03	3.03	NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE
5	View Details	[1052..1146]	deduced	N/A	No confident structure predictions are available.
6	View Details	[1147..1301]	MSA	1.071968	View MSA. No confident structure predictions are available.
7	View Details	[1302..1381]	deduced	N/A	No confident structure predictions are available.
8	View Details	[1382..1637]	MSA	1.05794	View MSA. No confident structure predictions are available.

Protein Overview: gek-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: