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View Structure Prediction Details

Protein: gek-PA
Organism: Drosophila melanogaster
Length: 1637 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gek-PA.

Description E-value Query
Range
Subject
Range
gi|119590214, gi... - gi|29373942|emb|CAD57746.1| CDC42 binding protein kinase alpha (DMPK-like) [Homo sapiens], gi|119590...
1027.0 [0..34] [1632..11]

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Predicted Domain #1
Region A:
Residues: [1-427]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEYESSEISD ITTGSCKKRL TFLKCILSDT TSDQKWAAEF GEDTEGHQFS LDYLLDTFIV  60
   61 LYDECSNSSL RREKGVSDFL KLSKPFVHIV RKLRLSRDDF DILKIIGRGA FGEVCVVQMI 120
  121 STEKVYAMKI LNKWEMLKRA ETACFREERD VLVFGDRQWI TNLHYAFQDN INLYLVMDYY 180
  181 CGGDLLTLLS KFEDKLPEDM AKFYITEMIL AINSIHQIRY VHRDIKPDNV LLDKRGHVRL 240
  241 ADFGSCLRLD KDGTVQSNVA VGTPDYISPE ILRAMEDGKG RYGTECDWWS LGVCMYEMLY 300
  301 GETPFYAESL VETYGKIMNH QNCFNLPSQE TLNYKVSETS QDLLCKLICI PENRLGQNGI 360
  361 QDFMDHPWFV GIDWKNIRQG PAPYVPEVSS PTDTSNFDVD DNDVRLTDSI PPSANPAFSG 420
  421 FHLPFIG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 85.39794
Match: 2f2uA
Description: No description for 2f2uA was found.

Predicted Domain #2
Region A:
Residues: [428-590]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTFSLTSSST LDSKKNQSSG FGDDTLDTIS SPQLAILPSN NSETPVDSVQ LKALNDQLAA  60
   61 LKQEKAELSK QHNEVFERLK TQDSELQDAI SQRNIAMMEY SEVTEKLSEL RNQKQKLSRQ 120
  121 VRDKEEELDG AMQKNDSLRN ELRKSDKTRR ELELHIEDAV IEA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.2
Match: 1jchA
Description: Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [591-980]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKEKKLREHA EDCCRQLQME LRKGSSSVET TMPLSISSEM SSYEIERLEL QFSEKLSHQQ  60
   61 TRHNMELEAL REQFSELENA NLALTKELQQ TQERLKYTQM ESITDSAETL LELKKQHDLE 120
  121 KSSWFEEKQR LSSEVNLKSK SLKELQAEDD EIFKELRMKR EAITLWERQM AEIIQWVSDE 180
  181 KDARGYLQAL ATKMTEELEY LKHVGTFNNN GVDNKNWRNR RSQKLDKMEL LNLQSALQRE 240
  241 IQAKNMISDE LSQTRSDLIS TQKEVRDYKK RYDSILHDFQ KKETELRDLQ KGGLEYSESF 300
  301 LNKSTHHGLS SAFFRDMSKN SEIIDSAESF GNESGDNFTP NFFQSGNSGM LFNYEPKYAG 360
  361 KNNKDHSSMK EASVSDLSRE ESDQLVKESQ 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.522879
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [981-1051]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKVPGNTAIH QFLVRTFSSP TKCNHCTSLM VGLTRQGVVC EICGFACHTI CCQKVPTTCP  60
   61 VPMDQTKRPL G

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.03
Match: 1tbnA
Description: NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 3.46734661087649 bayes_pls_golite062009
transcription regulator activity 2.82097223032126 bayes_pls_golite062009
binding 2.71288992341677 bayes_pls_golite062009
GTPase regulator activity 2.43859890356027 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.42148330229896 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.07238897772131 bayes_pls_golite062009
DNA binding 2.05972958088217 bayes_pls_golite062009
kinase activity 2.00903309297046 bayes_pls_golite062009
nucleic acid binding 1.91592331431516 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.83466699022067 bayes_pls_golite062009
enzyme regulator activity 1.78173505822139 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 1.76217210688028 bayes_pls_golite062009
small GTPase regulator activity 1.73820712435638 bayes_pls_golite062009
protein kinase activity 1.61903873760762 bayes_pls_golite062009
transferase activity 1.45394179515146 bayes_pls_golite062009
transcription factor activity 1.38590948364516 bayes_pls_golite062009
signal transducer activity 1.25050856744516 bayes_pls_golite062009
molecular transducer activity 1.25050856744516 bayes_pls_golite062009
protein binding 1.21002143294224 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.969266093401353 bayes_pls_golite062009
protein serine/threonine kinase activity 0.93378879973188 bayes_pls_golite062009
Ras GTPase activator activity 0.854618067843974 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.716569837044966 bayes_pls_golite062009
GTPase activator activity 0.531562206762648 bayes_pls_golite062009
kinase binding 0.409606963040614 bayes_pls_golite062009
catalytic activity 0.216721136299042 bayes_pls_golite062009
enzyme activator activity 0.160536263083511 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [1052-1146]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDPTRGIGTA YEGYVKVPKS GVIKRGWIRQ FVVVCDFKLF LYDISPDRCA LPSVSVSQVL  60
   61 DMRDPEFSVG SVRESDVIHA AKKDVPCIFK IKTAL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1147-1301]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDGGLSLNTL MLADNESEKS KWVIALGELH RILKRNSLPN TAIFKVNEIL DNTLSLIRNA  60
   61 LCSVIIYPNQ ILLGTEDGLF YINLDQYEIA RIGESKKILQ LWYIEEEQIL VILCGKQRNL 120
  121 RLLPIRALEA SDVEWIKVVE SKNCISACTG IIRRF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1302-1381]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNIVYSFIIA LKRPNNHTQI VVYEINRTRT RHQKTCEFTI GYMAQHLQIL SDMRLVVAHQ  60
   61 SGFTAYFLRG EATAMSLVHP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1382-1637]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENQLCAFLNY SGVDAVRVIE ILCPSGGNFG EYLLVFQTLA IYVDLQGRKS RDREIMYPAF  60
   61 PTYITFCDGH LLVFSDTHLD IFNTQTAEWV QSIGLKQSLP LNNLGNVVLS SVNDTPLIVY 120
  121 LSNIHTKGLL QYRDGNRKGL PSIKRRFSIR EINKTIKSDR RSKMISAPTN FNHISHMGPG 180
  181 DGIQNQRLLD LPTTLETADQ ACSPIIHSLS CIPQSRKSNF LEQVDANSDD YGNDNIISRT 240
  241 PSPMASSFMD GLSNND

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle