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Protein Overview: PIP5K59B-PA

General Information:
Name(s) found: PIP5K59B-PA / FBpp0071811 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene PIP5K59B is referred to in FlyBase by the symbol Dmel\PIP5K59B (CG3682, FBgn0034789). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:18762313..18768962. It has the cytological map location 59B4. Based on sequence similarity, it is predicted to have molecular function</span>: 1-phosphatidylinositol-4-phosphate 5-kinase activity. It is reported to be involved in the biological process</span>: phosphorylation. 4 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 729 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: phosphatidylinositol metabolic process [IEA]
    phosphorylation [NAS]
    Molecular Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASGDGDTIN TIDMDSSSAS QAKLAEPSNA STDHVGNSSP DLGNRPNRAS SKADKERKIG  60
   61 HRRVGEGGEI TYKKIQTSQI MGSIQLGIQH TVGSLASKPK RDLLMMDFWE IESITFPPEG 120
  121 SSLTPAHHYS EFRYKIYAPI AFRYFRDLFG IQPDDFMMSM CTSPLRELSN PGASGSIFYL 180
  181 TTDDEFIIKT VQHKEGEFLQ KLLPGYYMNL NQNPRTLLPK FFGLYCLQTS NAKNIRLVVM 240
  241 NNLLPSSVKM HLKYDLKGST FKRKANKAER AKKSPTYKDL DFMEQHPNGI FLEAETYAAL 300
  301 IKTIQRDCTV LESFKIMDYS LLLGVHNLDV ALKEKQSEQR KPLRAPLAED SDVDADDPLD 360
  361 GDAATGISRN KSVNRQRLVA HSTAMESIQA ESEPIDDEED VPPGGIPARS EKGERLLLYI 420
  421 GIIDILQSYR LKKKLEHTFK SIIHDGETVS VCRPSFYAQR FQNFMAKTVF RKIPSPLKHS 480
  481 PSKRKSLSKA IQRSIDSDNE VASRPVHASH SHSSGKIHQP AKPPTTEPTP AGAAGGAERG 540
  541 ATALGPATTS GASERAPPPV KQRTPAASNL KTRVPPPVPP RGSPRRKDAQ DRTTPGTTPS 600
  601 CSSTPPPAFD DISEDSSNKN SSSSIGRRSH HHHHHHQQSQ QHQQSYYLDR KMNIGPAYRG 660
  661 SYKEDIVSVS EVHLDTLLAV DTSSSSQYGS RGGLAWTPPA SGEGSTPTWT EGTPSFTDSS 720
  721 SSGDLDQLT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..477] PSI-BLAST 121.0 Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
    2 View Details [478..588] deduced N/A No confident structure predictions are available.
    3 View Details [589..729] FFAS03 0.965 No description for 2j63A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  3.04766540645426 bayes_pls_golite062009
  • kinase activity
    		•  2.85461858246731 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.23569102640176 bayes_pls_golite062009
  • catalytic activity
    		•  1.87792712964225 bayes_pls_golite062009
  • inositol or phosphatidylinositol kinase activity
    		•  1.5532961195371 bayes_pls_golite062009
  • transferase activity
    		•  1.20817067352467 bayes_pls_golite062009
  • signal transducer activity
    		•  1.15068527302487 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.15068527302487 bayes_pls_golite062009
  • binding
    		•  1.02604095388529 bayes_pls_golite062009
  • protein kinase activity
    		•  0.887549500886727 bayes_pls_golite062009
  • phosphatidylinositol phosphate kinase activity
    		•  0.657156789200518 bayes_pls_golite062009
  • 1-phosphatidylinositol-4-phosphate 5-kinase activity
    		•  0.392965917129829 bayes_pls_golite062009
  • protein binding
    		•  0.382966234080422 bayes_pls_golite062009
  • lipid kinase activity
    		•  0.376360034703563 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.0651942184115614 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle