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View Structure Prediction Details

Protein: PIP5K59B-PA
Organism: Drosophila melanogaster
Length: 729 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PIP5K59B-PA.

Description E-value Query
Range
Subject
Range
gi|17861744 - gi|17861744|gb|AAL39349.1| GH26019p [Drosophila melanogaster]
624.0 [0..1] [729..1]

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Predicted Domain #1
Region A:
Residues: [1-477]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASGDGDTIN TIDMDSSSAS QAKLAEPSNA STDHVGNSSP DLGNRPNRAS SKADKERKIG  60
   61 HRRVGEGGEI TYKKIQTSQI MGSIQLGIQH TVGSLASKPK RDLLMMDFWE IESITFPPEG 120
  121 SSLTPAHHYS EFRYKIYAPI AFRYFRDLFG IQPDDFMMSM CTSPLRELSN PGASGSIFYL 180
  181 TTDDEFIIKT VQHKEGEFLQ KLLPGYYMNL NQNPRTLLPK FFGLYCLQTS NAKNIRLVVM 240
  241 NNLLPSSVKM HLKYDLKGST FKRKANKAER AKKSPTYKDL DFMEQHPNGI FLEAETYAAL 300
  301 IKTIQRDCTV LESFKIMDYS LLLGVHNLDV ALKEKQSEQR KPLRAPLAED SDVDADDPLD 360
  361 GDAATGISRN KSVNRQRLVA HSTAMESIQA ESEPIDDEED VPPGGIPARS EKGERLLLYI 420
  421 GIIDILQSYR LKKKLEHTFK SIIHDGETVS VCRPSFYAQR FQNFMAKTVF RKIPSPL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 121.0
Match: 1bo1A
Description: Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 3.04766540645426 bayes_pls_golite062009
kinase activity 2.85461858246731 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.23569102640176 bayes_pls_golite062009
catalytic activity 1.87792712964225 bayes_pls_golite062009
inositol or phosphatidylinositol kinase activity 1.5532961195371 bayes_pls_golite062009
transferase activity 1.20817067352467 bayes_pls_golite062009
signal transducer activity 1.15068527302487 bayes_pls_golite062009
molecular transducer activity 1.15068527302487 bayes_pls_golite062009
binding 1.02604095388529 bayes_pls_golite062009
protein kinase activity 0.887549500886727 bayes_pls_golite062009
phosphatidylinositol phosphate kinase activity 0.657156789200518 bayes_pls_golite062009
1-phosphatidylinositol-4-phosphate 5-kinase activity 0.392965917129829 bayes_pls_golite062009
protein binding 0.382966234080422 bayes_pls_golite062009
lipid kinase activity 0.376360034703563 bayes_pls_golite062009
protein serine/threonine kinase activity 0.0651942184115614 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [478-588]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KHSPSKRKSL SKAIQRSIDS DNEVASRPVH ASHSHSSGKI HQPAKPPTTE PTPAGAAGGA  60
   61 ERGATALGPA TTSGASERAP PPVKQRTPAA SNLKTRVPPP VPPRGSPRRK D

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [589-729]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQDRTTPGTT PSCSSTPPPA FDDISEDSSN KNSSSSIGRR SHHHHHHHQQ SQQHQQSYYL  60
   61 DRKMNIGPAY RGSYKEDIVS VSEVHLDTLL AVDTSSSSQY GSRGGLAWTP PASGEGSTPT 120
  121 WTEGTPSFTD SSSSGDLDQL T

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.965
Match: 2j63A
Description: No description for 2j63A was found.

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