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Protein Overview: sktl-PA, FBpp031...

General Information:
Name(s) found: FBpp0310605 [FlyBase]
FBpp0309638 [FlyBase]
sktl-PA / FBpp0071491 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • type=protein; loc=2R:complement(16715497..16717875); ID=FBpp0310605; name=sktl-PC; parent=FBgn0016984,FBtr0344196; dbxref=FlyBase:FBpp0310605,FlyBase_Annotation_IDs:CG9985-PC; MD5=e1beb5239ae8b0bb55ac9b7792549e15; length=792; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=2R:complement(16715497..16717875); ID=FBpp0309638; name=sktl-PB; parent=FBgn0016984,FBtr0342801; dbxref=FlyBase:FBpp0309638,FlyBase_Annotation_IDs:CG9985-PB; MD5=e1beb5239ae8b0bb55ac9b7792549e15; length=792; release=r5.56; species=Dmel; [FlyBase]
  • The gene skittles is referred to in FlyBase by the symbol Dmel\sktl (CG9985, FBgn0016984). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:16714916..16719919. It has the cytological map location 57B3. Based on sequence similarity, it is predicted to have molecular function</span>: 1-phosphatidylinositol-4-phosphate 5-kinase activity. There is experimental evidence that it is involved in the biological process</span>: maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification; oocyte microtubule cytoskeleton polarization; autophagic cell death; cortical actin cytoskeleton organization; salivary gland cell autophagic cell death; peripheral nervous system development. 31 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; egg; ovary; macrochaeta; embryonic peripheral nervous system; wing; imaginal disc; scutum; dorsal appendage. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 792 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    cell cortex [IDA]
    Biological Process: cortical actin cytoskeleton organization [IMP]
    maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification [IMP]
    autophagic cell death [IEP]
    peripheral nervous system development [IMP]
    oocyte microtubule cytoskeleton polarization [IMP]
    salivary gland cell autophagic cell death [IEP]
    phosphatidylinositol metabolic process [IEA]
    phosphorylation [NAS]
    Molecular Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity [ISS][NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTRVELELE PVGKQDRLKD QPDDENEPLE NQLELEQEHK SLLTPVKIPP AQTASPDQEA  60
   61 TPSTPPPMSL QPGTSRQLFR DAAMAHGGQE TTSLLQQELN NIAATQTPAS KLRSASSTLD 120
  121 ASISRNPSTT GGKHEKKLGH RRVAEGGEVT YKKIQSKQIM GSIQLGIQHT VGSLASKPKR 180
  181 DLLMNDFWEM ETISFPPDGS SITPAHHYND FRFKVYAPIA FRYFRDLFGI APDDFLMSMC 240
  241 ASPLRELSNP GASGSIFYLT TDDEFIIKTV QKKECEFLQK LLPGYYMNLS QNPRTLLPKF 300
  301 FGLYCFHYNS KNVRLVAMNN LLPSDIKMHC KYDLKGSSFR RKASKAERQK ASPTFKDLDF 360
  361 AEHHPNGIFL ETDKYNALMS TIKRDCMVLE SFQIMDYSLL VGIHNLDLAA KEKREERILN 420
  421 ARAKLQRKES AAQGPPSLNP DDDAPEADQN QLQAVASYAS IPGTSAGAAL NRTRSMNRQR 480
  481 LVAHSTALES ITADMDVPLE EDEDVPAGGI PARSENDERL ILYIGIIDIL QSYRLEKKLE 540
  541 HTFKSILYNG DTVSVCRPSF YAKRFQDAMG KQVFKKTPTF PLKHSPSKRK TSTTQLRSPA 600
  601 SRLPPLSTPT NAVRQPIMTM SGMSTPPPAF DDISEEDITA ASTSSLQQQR SSNQSNNNRG 660
  661 ETEVALREGN NTRGGSGEPS STYHTQYSYD SSGRTGSALT SDYSDDESTG TDLSSRLPKL 720
  721 RTHRLTKTSV QVTTVGYVEG VDTPPKGGQD VVHADVNGKT TMTTTTMLTT TKTAHIQAPS 780
  781 YTSTLVLNDL PR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..139] deduced N/A No confident structure predictions are available.
    2 View Details [140..576] PSI-BLAST 107.0 Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
    3 View Details [577..792] MSA 1.066997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • inositol or phosphatidylinositol kinase activity
    		•  4.31726963575315 bayes_pls_golite062009
  • lipid kinase activity
    		•  3.63026201392483 bayes_pls_golite062009
  • phosphatidylinositol phosphate kinase activity
    		•  3.5005619620026 bayes_pls_golite062009
  • 1-phosphatidylinositol-4-phosphate 5-kinase activity
    		•  3.00599233846946 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.8512866333787 bayes_pls_golite062009
  • kinase activity
    		•  2.68971389233526 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.48646215276903 bayes_pls_golite062009
  • catalytic activity
    		•  1.87792712964225 bayes_pls_golite062009
  • binding
    		•  1.66593042987179 bayes_pls_golite062009
  • transferase activity
    		•  1.20817067352467 bayes_pls_golite062009
  • signal transducer activity
    		•  1.15068527302487 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.15068527302487 bayes_pls_golite062009
  • protein kinase activity
    		•  0.709372924978886 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.489382280175196 bayes_pls_golite062009
  • ligase activity
    		•  0.435608917599349 bayes_pls_golite062009
  • protein binding
    		•  0.382966234080422 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.189737258618863 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle