Protein Overview: endoB-PA

General Information:
Name(s) found:	endoB-PA / FBpp0085742 [FlyBase]
Description(s) found: Found 21 descriptions. SHOW ALL	The gene endophilin B is referred to in FlyBase by the symbol Dmel\endoB (CG9834, FBgn0034433). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15194952..15198197. It has the cytological map location 56C10. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding. It is reported to be involved in the biological process</span>: membrane organization. 4 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	390 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IEA]
Biological Process:	cellular membrane organization [NAS]
Molecular Function:	protein binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNINLPNFNV KNLVKEAGST ISRVVQLTEE KLGTTERTEY DLHFQNLAER ADVTKTWTEK  60
   61 IVRDTESVLI PNPQNRVEDF IFEKIEKSKP KRLSNLEHLA LDMIEAGGDF GQDLPYGQAL 120
  121 IKVGQAEQKL GQCEHDFIAT SGICFTQPLR KFLDGEMKTI GKERGILETK RLDLDACKNR 180
  181 VKKARSMLGQ QSKDGISPEA VLEQAERDLR VAQAEFDRQA EITKLLLDGI STSQASHLRH 240
  241 LHAFIQTQVR YYKQCGDVME QLQRELANLG GPTPYIPLDV NEASASKSNI SSGAAARGPG 300
  301 NNHSANMAAT GHKPNQPMHV STDQMQRARV LCSYDAKDHT ELNLSANEVI FVTECSPVNE 360
  361 DYMYGKQGLL KGLVPRAFVE MLDEEHDVTL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..267]	PSI-BLAST	33.0	Crystal structure of endophilin-A1 BAR domain
2	View Details	[268..390]	PSI-BLAST	12.69897	Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
protein binding	2.92353432746981	bayes_pls_golite062009
binding	2.43584893484993	bayes_pls_golite062009
lysophosphatidic acid acyltransferase activity	1.43515660906576	bayes_pls_golite062009
signal transducer activity	1.15315260510573	bayes_pls_golite062009
molecular transducer activity	1.15315260510573	bayes_pls_golite062009
identical protein binding	0.652723321884221	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.127423274812986	bayes_pls_golite062009
cytoskeletal protein binding	0.11971814425029	bayes_pls_golite062009
pyrophosphatase activity	0.0898200140309309	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0808236947742297	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0782188789090384	bayes_pls_golite062009

2

Term	Confidence	Notes
protein binding	3.13677730481089	bayes_pls_golite062009
binding	2.63972476345585	bayes_pls_golite062009
cytoskeletal protein binding	1.67112127425228	bayes_pls_golite062009
signal transducer activity	1.34867629228264	bayes_pls_golite062009
molecular transducer activity	1.34867629228264	bayes_pls_golite062009
transporter activity	1.30447542854757	bayes_pls_golite062009
transmembrane transporter activity	1.08558010881058	bayes_pls_golite062009
actin binding	0.75525840382431	bayes_pls_golite062009
substrate-specific transporter activity	0.566172161499832	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.325817349097199	bayes_pls_golite062009
structural molecule activity	0.236653863910566	bayes_pls_golite062009
receptor binding	0.0742205785215131	bayes_pls_golite062009
ion transmembrane transporter activity	0.00508584255499911	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
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