Protein Overview: botv-PA

General Information:
Name(s) found:	botv-PA / FBpp0085763 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7302518\|gb\|AAF57601.1\| brother of tout-velu [Drosophila melanogaster] [NCBI NR] gi\|61212928\|sp\|Q9XZ08.1\|EXT3_DROME RecName: Full=Exostosin-3; AltName: Full=Protein brother of tout-velu [NCBI NR] gi\|4972708\|gb\|AAD34749.1\| unknown [Drosophila melanogaster] [NCBI NR] gi\|20160388\|dbj\|BAB89399.1\| heparan sulfate GlcNAc transferase-I/II [Drosophila melanogaster] [NCBI NR] gi\|17647209\|ref\|NP_523790.1\| brother of tout-velu [Drosophila melanogaster] [NCBI NR] Exostosin-3 OS=Drosophila melanogaster GN=botv PE=1 SV=1 [Swiss-Prot] The gene brother of tout-velu is referred to in FlyBase by the symbol Dmel\botv (CG15110, FBgn0027535). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15017099..15021223. It has the cytological map location 56B5. There is experimental evidence that it has the molecular function</span>: acetylglucosaminyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: decapentaplegic receptor signaling pathway; smoothened signaling pathway; glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; Wnt receptor signaling pathway; heparan sulfate proteoglycan biosynthetic process. 10 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG15110-PA translation from_gene[CG15110 botv FBgn0027535] seq_release:3 mol_weight=111001 cds_boundaries:(2R:14,193,410..14,196,835[+]) aa_length:972 transcript_info:[CG15110-RA seq_release:3] gene_info:[gene symbol:botv FBgn0027535 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta] (Q9XZ08) BCDNA:LD21192 protein (Heparan sulfate GlcNAc transferase-I/II) [DrosMelano7227.FASTAC.txt] (AE003797) BcDNA:LD21192 gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG15110-PA [Drosophila melanogaster]gi\|17647209\|ref\|NP_523790.1\| CG15110-PA [Drosophila melanogaster]gi\|4972708\|gb\|AAD34749.1\| unknown [Drosophila melanogaster]gi\|20160388\|dbj\|BAB89399.1\| heparan sulfate GlcNAc transferase-I/II [Drosophila melanogaster [nrdb_11152004_Chlamydomonas] type=protein; loc=2R:join(15017195..15017422,15017873..15017998,15018059..15020623); ID=FBpp0085763; name=botv-PA; parent=FBgn0027535,FBtr0086579; dbxref=FlyBase:FBpp0085763,FlyBase_Annotation_IDs:CG15110-PA,GB_protein:AAF57601.1,REFSEQ:NP_523790,GB_prote [fly-100309-contam.fasta] Exostosin-3 (Protein brother of tout-velu) [nr-271106-contam.fasta] unknown [Drosophila melanogaster] [nr-271106-contam.fasta] heparan sulfate GlcNAc transferase-I/II [Drosophila melanogaster] [nr-271106-contam.fasta] CG15110-PA [Drosophila melanogaster] [nr-271106-contam.fasta] brother of tout-velu CG15110-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2R:join(15017195..15017422,15017873..15017998,15018059..15020623); ID=FBpp0085763; name=botv-PA; parent=FBgn0027535,FBtr0086579; dbxref=FlyBase:FBpp0085763,FlyBase_Annotation_IDs:CG15110-PA,GB_protein:AAF57601.1,REFSEQ:NP_523790,GB_protein:AAF57601; MD5=2c49226f504d1bfa4a9e23ce9d3b80f0; length=972; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2R:join(15017195..15017422,15017873..15017998,15018059..15020623); ID=FBpp0085763; name=botv-PA; parent=FBgn0027535,FBtr0086579; dbxref=FlyBase:FBpp0085763,FlyBase_Annotation_IDs:CG15110-PA,GB_protein:AAF57601.1,REFSEQ:NP_523790,GB_protein:AAF57601; MD5=2c49226f504d1bfa4a9e23ce9d3b80f0; length=972; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2R:join(15017195..15017422,15017873..15017998,15018059..15020623); ID=FBpp0085763; name=botv-PA; parent=FBgn0027535,FBtr0086579; dbxref=FlyBase:FBpp0085763,FlyBase_Annotation_IDs:CG15110-PA,GB_protein:AAF57601.1,REFSEQ:NP_523790,GB_protein:AAF57601,FlyMine:FBpp0085763,modMine:FBpp0085763; MD5=2c49226f504d1bfa4a9e23ce9d3b80f0; length=972; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2R:join(19129690..19129917,19130368..19130493,19130554..19133118); ID=FBpp0085763; name=botv-PA; parent=FBgn0027535,FBtr0086579; dbxref=FlyBase:FBpp0085763,FlyBase_Annotation_IDs:CG15110-PA,GB_protein:AAF57601.1,REFSEQ:NP_523790,GB_protein:AAF57601,FlyMine:FBpp0085763,modMine:FBpp0085763; MD5=2c49226f504d1bfa4a9e23ce9d3b80f0; length=972; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2R:join(19129690..19129917,19130368..19130493,19130554..19133118); ID=FBpp0085763; name=botv-PA; parent=FBgn0027535,FBtr0086579; dbxref=FlyBase:FBpp0085763,FlyBase_Annotation_IDs:CG15110-PA,GB_protein:AAF57601.1,REFSEQ:NP_523790,GB_protein:AAF57601,FlyMine:FBpp0085763,modMine:FBpp0085763; MD5=2c49226f504d1bfa4a9e23ce9d3b80f0; length=972; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0085763 type=protein; loc=2R:join(19129690..19129917,19130368..19130493,19130554..19133118); ID=FBpp0085763; name=botv-PA; parent=FBgn0027535,FBtr0086579; dbxref=FlyBase:FBpp0085763,FlyBase_Annotation_IDs:CG15110-PA,GB_protein:AAF57601.1,REFSEQ:NP_523790,GB_protein:AAF57601,FlyMine:FBpp0085763,modMine:FBpp0085763; MD5=2c49226f504d1bfa4a9e23ce9d3b80f0; length=972; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2R:join(19129690..19129917,19130368..19130493,19130554..19133118); ID=FBpp0085763; name=botv-PA; parent=FBgn0027535,FBtr0086579; dbxref=FlyBase:FBpp0085763,FlyBase_Annotation_IDs:CG15110-PA,GB_protein:AAF57601.1,REFSEQ:NP_523790,GB_protein:AAF57601,UniProt/Swiss-Prot:Q9XZ08,FlyMine:FBpp0085763,modMine:FBpp0085763; MD5=2c49226f504d1bfa4a9e23ce9d3b80f0; length=972; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	972 amino acids
Gene Ontology:
Cellular Component:	integral to membrane [UNKNOWN] endoplasmic reticulum [IDA] Golgi apparatus [IDA] intrinsic to endoplasmic reticulum membrane [IEA]
Biological Process:	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [IMP][NAS] heparan sulfate proteoglycan biosynthetic process [IDA][NAS] glycosaminoglycan biosynthetic process [IMP] segment polarity determination [NAS] smoothened signaling pathway [IMP] Wnt receptor signaling pathway [IMP] N-acetylglucosamine metabolic process [ISS] decapentaplegic receptor signaling pathway [IMP]
Molecular Function:	heparan sulfate N-acetylglucosaminyltransferase activity [NAS] acetylglucosaminyltransferase activity [IDA][ISS][NAS] glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPAYDLGHS GEAYQPLDTG SGGGNEACAP NSSSAQIRHS MGFRTSWMRQ FRRYKLPMVL  60
   61 LMLLFLVSCL AYRILSVEQD APPLDLHRSS PLLDAYEDFS AMRAGDLKMR IEEMVRIKST 120
  121 VSVELRELES RRQKLQSDIS QYNQKIEELK QELLREQTEL ERLKISVEQA QVAQREAVQR 180
  181 NTPDLALPRS LLPNTLPRKS NPITGGMAAS CEMHNCFNHS RCSLTSGFPV YLYDPDEHSV 240
  241 QRKGYDIDGF LKTTLKQTLG YNAHIVKDPK HACIYLVLVG EALLEQDLLR NNRYAAQEAE 300
  301 HQQPSTPTLE NDCPVDMEKL YSLPYWGGDG RNHVLLNLAR RDLTSHRTNP LYRQNTMRAI 360
  361 VVQSAFEREQ FRPGYDLIVP PILGPPGGDV WQECAEMVPA RRKYLLTYQG ELRPKQSSLN 420
  421 PLDAFILEHL ADMAKGATQD QFVLQFQCVP ATEQQEGDSL PDWTLCGSDS SRRQLLKDST 480
  481 FSLILPPLNG RVSSTLMLAR IYEALRSGAV PVILGADELR LPYAETVDWR RTALLLPKAR 540
  541 ITELHFLLRA VQDADLLLLR RQGRLIWERY LSSVQATVDT VIASLRDRLG IPPRPVPSVI 600
  601 AQSVFNSTFI PLKSDPPVGL DTEPEESLGP IEPPYPSPAF RRNYTILRMQ AKEAWNDWLD 660
  661 PFYLYPQLPF DPALPSEAKF MGSHTGFRPI GKGLGGAGKE FGESLGGNYP REQFTIVMLT 720
  721 YEREQVLMDS LGRLYGLPYL HKVVVVWNSP KPPLDDLRWP DIGVPVAVLR APRNSLNNRF 780
  781 LPFDVIETEA VLSVDDDAHL RHDEILFGFR VWREHRDRVV GFPGRYHAWD LGNPNGQWHY 840
  841 NSNYSCELSM VLTGAAFVHK YYLYLYTYHL PQAIRDKVDE YMNCEDIAMN FLVSHITRKP 900
  901 PVKVTSRWTF RCPGCPVSLS EDDTHFQERH KCINFFSRVF GYTPLLNTQY RADSILFKTR 960
  961 IPHDKQKCFK YI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..209]	PSI-BLAST	6.39794	No description for 2i1jA was found.
2	View Details	[210..354]	MSA	1.119988	View MSA. No confident structure predictions are available.
3	View Details	[355..608]	FFAS03	1.07	No description for 2nzwA was found.
4	View Details	[609..694]	deduced	N/A	No confident structure predictions are available.
5	View Details	[695..972]	PSI-BLAST	98.045757	Alpha-1,4-N-acetylhexosaminyltransferase (Alpha-GalNAcT EXTL2)

Protein Overview: botv-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: