Protein Overview: botv-PA

General Information:
Name(s) found:	botv-PA / FBpp0085763 [FlyBase]
Description(s) found: Found 25 descriptions. SHOW ALL	The gene brother of tout-velu is referred to in FlyBase by the symbol Dmel\botv (CG15110, FBgn0027535). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15017099..15021223. It has the cytological map location 56B5. There is experimental evidence that it has the molecular function</span>: acetylglucosaminyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: decapentaplegic receptor signaling pathway; smoothened signaling pathway; glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; Wnt receptor signaling pathway; heparan sulfate proteoglycan biosynthetic process. 10 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	972 amino acids
Gene Ontology:
Cellular Component:	integral to membrane [UNKNOWN] endoplasmic reticulum [IDA] Golgi apparatus [IDA] intrinsic to endoplasmic reticulum membrane [IEA]
Biological Process:	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [IMP][NAS] heparan sulfate proteoglycan biosynthetic process [IDA][NAS] glycosaminoglycan biosynthetic process [IMP] segment polarity determination [NAS] smoothened signaling pathway [IMP] Wnt receptor signaling pathway [IMP] N-acetylglucosamine metabolic process [ISS] decapentaplegic receptor signaling pathway [IMP]
Molecular Function:	heparan sulfate N-acetylglucosaminyltransferase activity [NAS] acetylglucosaminyltransferase activity [IDA][ISS][NAS] glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPAYDLGHS GEAYQPLDTG SGGGNEACAP NSSSAQIRHS MGFRTSWMRQ FRRYKLPMVL  60
   61 LMLLFLVSCL AYRILSVEQD APPLDLHRSS PLLDAYEDFS AMRAGDLKMR IEEMVRIKST 120
  121 VSVELRELES RRQKLQSDIS QYNQKIEELK QELLREQTEL ERLKISVEQA QVAQREAVQR 180
  181 NTPDLALPRS LLPNTLPRKS NPITGGMAAS CEMHNCFNHS RCSLTSGFPV YLYDPDEHSV 240
  241 QRKGYDIDGF LKTTLKQTLG YNAHIVKDPK HACIYLVLVG EALLEQDLLR NNRYAAQEAE 300
  301 HQQPSTPTLE NDCPVDMEKL YSLPYWGGDG RNHVLLNLAR RDLTSHRTNP LYRQNTMRAI 360
  361 VVQSAFEREQ FRPGYDLIVP PILGPPGGDV WQECAEMVPA RRKYLLTYQG ELRPKQSSLN 420
  421 PLDAFILEHL ADMAKGATQD QFVLQFQCVP ATEQQEGDSL PDWTLCGSDS SRRQLLKDST 480
  481 FSLILPPLNG RVSSTLMLAR IYEALRSGAV PVILGADELR LPYAETVDWR RTALLLPKAR 540
  541 ITELHFLLRA VQDADLLLLR RQGRLIWERY LSSVQATVDT VIASLRDRLG IPPRPVPSVI 600
  601 AQSVFNSTFI PLKSDPPVGL DTEPEESLGP IEPPYPSPAF RRNYTILRMQ AKEAWNDWLD 660
  661 PFYLYPQLPF DPALPSEAKF MGSHTGFRPI GKGLGGAGKE FGESLGGNYP REQFTIVMLT 720
  721 YEREQVLMDS LGRLYGLPYL HKVVVVWNSP KPPLDDLRWP DIGVPVAVLR APRNSLNNRF 780
  781 LPFDVIETEA VLSVDDDAHL RHDEILFGFR VWREHRDRVV GFPGRYHAWD LGNPNGQWHY 840
  841 NSNYSCELSM VLTGAAFVHK YYLYLYTYHL PQAIRDKVDE YMNCEDIAMN FLVSHITRKP 900
  901 PVKVTSRWTF RCPGCPVSLS EDDTHFQERH KCINFFSRVF GYTPLLNTQY RADSILFKTR 960
  961 IPHDKQKCFK YI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
transferase activity, transferring hexosyl groups	4.49413422196176	bayes_pls_golite062009
UDP-glycosyltransferase activity	4.08451171179562	bayes_pls_golite062009
glucuronosyltransferase activity	4.02728111834164	bayes_pls_golite062009
heparan sulfate N-acetylglucosaminyltransferase activity	3.99063852016951	bayes_pls_golite062009
acetylgalactosaminyltransferase activity	3.4614674054855	bayes_pls_golite062009
polypeptide N-acetylgalactosaminyltransferase activity	3.19923094610567	bayes_pls_golite062009
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	3.19489360002767	bayes_pls_golite062009
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	2.76301940238613	bayes_pls_golite062009
mannosyltransferase activity	2.61384249067286	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	2.60650378115696	bayes_pls_golite062009
catalytic activity	1.88676710996045	bayes_pls_golite062009
transferase activity	1.47184463413038	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.15057449386373	bayes_pls_golite062009
cytidylyltransferase activity	1.14240569193314	bayes_pls_golite062009
nucleotidyltransferase activity	1.03393419806381	bayes_pls_golite062009
glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	0.999230163117909	bayes_pls_golite062009
protein binding	0.967722609820275	bayes_pls_golite062009
alpha-1,2-mannosyltransferase activity	0.82476668382543	bayes_pls_golite062009
binding	0.667238976803188	bayes_pls_golite062009
UDP-N-acetylglucosamine diphosphorylase activity	0.513376694534047	bayes_pls_golite062009
uridylyltransferase activity	0.321928989676507	bayes_pls_golite062009
mannose-phosphate guanylyltransferase activity	0.2363835251362	bayes_pls_golite062009
UDP-galactosyltransferase activity	0.10185872015123	bayes_pls_golite062009
galactosyltransferase activity	0.0931461042017721	bayes_pls_golite062009
acetylglucosaminyltransferase activity	0.0562130308868509	bayes_pls_golite062009
guanylyltransferase activity	0.0539392112504681	bayes_pls_golite062009
intramolecular oxidoreductase activity	0.0122078907283503	bayes_pls_golite062009

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..209]	PSI-BLAST	6.39794	No description for 2i1jA was found.
2	View Details	[210..354]	MSA	1.119988	View MSA. No confident structure predictions are available.
3	View Details	[355..608]	FFAS03	1.07	No description for 2nzwA was found.
4	View Details	[609..694]	deduced	N/A	No confident structure predictions are available.
5	View Details	[695..972]	PSI-BLAST	98.045757	Alpha-1,4-N-acetylhexosaminyltransferase (Alpha-GalNAcT EXTL2)

Protein Overview: botv-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: