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Protein Overview: FBpp0309235, eIF...

General Information:
Name(s) found: FBpp0309235 [FlyBase]
eIF3-S8-PA / FBpp0086013 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • type=protein; loc=2R:join(13553572..13553664,13553727..13556366); ID=FBpp0309235; name=eIF3-S8-PB; parent=FBgn0034258,FBtr0340269; dbxref=FlyBase:FBpp0309235,FlyBase_Annotation_IDs:CG4954-PB; MD5=d2c71da1cca2c3e0984f6a9688d8d595; length=910; release=r5.56; species=Dmel; [FlyBase]
  • The gene eIF3-S8 is referred to in FlyBase by the symbol Dmel\eIF3-S8 (CG4954, FBgn0034258). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13553183..13556749. It has the cytological map location 54D4. Based on sequence similarity, it is predicted to have molecular function</span>: translation initiation factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: translational initiation. 22 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 910 amino acids

    Gene Ontology:
    Cellular Component: cytosol [ISS]
    eukaryotic translation initiation factor 3 complex [ISS]
    Biological Process: translational initiation [ISS]
    Molecular Function: translation initiation factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRFFANGSE SESESSEEEI QATNFNKASA FQFSDDEEEV KRVVRSTKEK RYENLTSIIK  60
   61 TIRNHKKIKD IPNTLSSFED LTRAYQKALP VISKEENGIT PRFYIRCLAE LEDFINEVWE 120
  121 DREGRKNLSK NNSKSLGTLR QKVRKYIKDF EDDLSRFREA PDQESEAEDE VVALESDGGD 180
  181 AGDDSDAGVK PTEAVPKAVK SAPAKAAPAD DDDSDDSIDW DSDSESETES SDDENQYQNM 240
  241 RERFLKRTTE KEEKDDDKRK DKRKEQKTKI RKRAEDDEDG EWETVVKGHV VEKPKMFEKD 300
  301 AEIDVPLVLA KLLEIMSARG KKRTDRRLQI DLLFELRDIS DQHNLGTAVS VKIHFNIISA 360
  361 IYDYNQKISE PMKLEHWALL LEVMQSMMKL LLANADIIMS ESVAEEHEEY ATSPFYVRGC 420
  421 PLAAVERLDD EFVKLLKECD PHSNDYVSRL KDEVNVVKTI ELVLQYFERS GTNNERCRIY 480
  481 LRKIEHLYYK FDPEVLKKKR GELPATTSTS VDVMDKLCKF IYAKDDTDRI RTRAILAHIY 540
  541 HHAMHDNWFQ ARDLVLMSHL QDNIDAADPA TRILYNRMMA NLGLCAFRQG NVKDAHHCLV 600
  601 DLMVTGKPKE LLAQGLLPQR QHERSAEQEK IEKQRQMPFH MHINLELLEC VYLVSAMLLE 660
  661 IPYIAAHEFD ARRRMISKTF YQQLRSSERQ SLVGPPESMR EHVVAAAKAM RCGNWQACAN 720
  721 FIVNKKMNTK VWDLFYESDR VREMLTKFIK EESLRTYLFT YSNVYTSISI PSLAQMYELP 780
  781 VPKVHSIISK MIINEELMAS LDDPSETVGM HRSEPSRLQA LAMQFVDKVT NLVDVNEKVF 840
  841 DMKQGNFFQR GNMGNRGDRG YNRNQNNQGG NWLGQRRDRN NRNRNQRGHH KNNQDRQQQQ 900
  901 QQQVQTIDEE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..291] PSI-BLAST 12.0 Heavy meromyosin subfragment
    2 View Details [292..365] PSI-BLAST 4.69897 No description for 2i1jA was found.
    3 View Details [366..567] deduced N/A No confident structure predictions are available.
    4 View Details [568..686] MSA 1.051952 View MSA. No confident structure predictions are available.
    5 View Details [687..843] FFAS03 2.53 Solution structure of the PCI domain
    6 View Details [844..910] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • transcription regulator activity
    		•  2.85334044543318 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.8293727459515 bayes_pls_golite062009
  • DNA binding
    		•  2.66906990480864 bayes_pls_golite062009
  • binding
    		•  2.14387047687719 bayes_pls_golite062009
  • transcription factor activity
    		•  1.97506348695089 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.764002516817766 bayes_pls_golite062009
  • structural molecule activity
    		•  0.756450227832198 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.665091289283954 bayes_pls_golite062009
  • transcription activator activity
    		•  0.542530812773621 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.423955395883599 bayes_pls_golite062009
  • protein binding
    		•  0.0300097532511948 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle