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Protein Overview: RhoGEF2-PD, RhoG...

General Information:
Name(s) found: RhoGEF2-PD / FBpp0086125 [FlyBase]
RhoGEF2-PF / FBpp0086124 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • The gene RhoGEF2 is referred to in FlyBase by the symbol Dmel\RhoGEF2 (CG9635, FBgn0023172). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12914746..12932161. It has the cytological map location 53E4-53F1. Based on sequence similarity, it is predicted to have molecular function</span>: diacylglycerol binding; Rho guanyl-nucleotide exchange factor activity. There is experimental evidence for 14 unique biological process</span> terms, many of which group under: anatomical structure development; regulation of developmental process; organ morphogenesis; regulation of cell morphogenesis; actin filament-based process; organ development; organelle organization; anatomical structure formation involved in morphogenesis; regulation of cellular component organization; reproductive process in a multicellular organism; embryonic development via the syncytial blastoderm; regulation of neurogenesis; cytoskeleton organization. 33 alleles are reported. The phenotypes of these alleles are annotated with: embryonic salivary gland; dorsal mesothoracic disc; embryonic posterior spiracle; epithelial cell; wing; mesoderm anlage; ventral midline. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene RhoGEF2 is referred to in FlyBase by the symbol Dmel\RhoGEF2 (CG9635, FBgn0023172). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12914746..12932161. It has the cytological map location 53E4-53F1. Based on sequence similarity, it is predicted to have molecular function</span>: diacylglycerol binding; Rho guanyl-nucleotide exchange factor activity. There is experimental evidence for 14 unique biological process</span> terms, many of which group under: anatomical structure development; regulation of developmental process; organ morphogenesis; regulation of cell morphogenesis; actin filament-based process; organ development; organelle organization; anatomical structure formation involved in morphogenesis; regulation of cellular component organization; reproductive process in a multicellular organism; embryonic development via the syncytial blastoderm; regulation of neurogenesis; cytoskeleton organization. 33 alleles are reported. The phenotypes of these alleles are annotated with: embryonic salivary gland; dorsal mesothoracic disc; embryonic posterior spiracle; epithelial cell; wing; mesoderm anlage; ventral midline. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2559 amino acids

    Gene Ontology:
    Cellular Component: lateral plasma membrane [IDA]
    apical part of cell [IDA]
    actomyosin contractile ring [IDA]
    basal part of cell [IDA]
    apical cortex [IDA]
    apical plasma membrane [IDA]
    actin cap [IDA]
    Biological Process: regulation of cell shape [IDA][IMP]
    ventral furrow formation [IMP]
    regulation of Rho protein signal transduction [IEA]
    spiracle morphogenesis, open tracheal system [IMP]
    posterior midgut invagination [IMP]
    germ-band extension [IMP]
    actin filament organization [IMP]
    anterior midgut invagination [IMP]
    pole cell development [IMP]
    cellularization [IMP]
    gastrulation [TAS]
    regulation of axonogenesis [IGI]
    morphogenesis of embryonic epithelium [IMP]
    regulation of embryonic cell shape [IGI][IMP][NAS]
    actin cytoskeleton reorganization [IMP]
    pseudocleavage during syncytial blastoderm formation [IMP]
    Molecular Function: protein binding [IEA]
    diacylglycerol binding [ISS]
    Rho guanyl-nucleotide exchange factor activity [IEA][ISS][NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDPSIKKRL LDLYTDEHEY DEVQEIPEES SIQPPETSTS HTSTNGSSHS GPGTATGPGA  60
   61 TSAGPSAGAP QSPVIVVDSV PELPAPKQKS VKNSKSKQKQ KQLANKSKIP RSPSLASSLS 120
  121 SLASSLSGHR DRDKDRDKDR ENQNAVPPQT PPLPPSYKQN QMNGDSTAAA GGGVSAPATP 180
  181 TTANNNNASH NNGSIMGGGV QLNQSDNSNP VLQAPGERSS LNLTPLSRDL SGGHTQESTT 240
  241 PATTPSTPSL ALPKNFQYLT LTVRKDSNGY GMKVSGDNPV FVESVKPGGA AEIAGLVAGD 300
  301 MILRVNGHEV RLEKHPTVVG LIKASTTVEL AVKRSQKLTR PSSVSVVTPS TPILSGRDRT 360
  361 ASITGPQPVD SIKRREMETY KIQTLQKMLE QEKLNLERLK SDQNNPSYKL SEANIRKLRE 420
  421 QLHQVGAEDA PTVKLQAAAG NKNTALLTPN QIQHLSASAT HSNQQFHHLH HHHNLHNNNY 480
  481 PPQQQPASTS PAFLSLLPRS LSSLSLGTRK NKTEKDLTTS SPFGLTTDFL QQQRMSHQAE 540
  541 SMSQSMHQHT STPTSQQFFH PHQQQHRFKE TGPTSKGKNK FLISRSLIEE DVPPPLPQRN 600
  601 PPRQLNLDLK NGNASPGGSH LVAPVSDLDR ATSPQLNRSQ QQQLPSSTDN SPSNAKSKRS 660
  661 KIKTKALSDP KMSTQMFLQM ESASAAGAAG GSIEVDGGPP PLPPRLPGMM TEDMSRGSCQ 720
  721 NLAQPNSVGT AFNYPLVSTT TAVQNDNLNI AFPLSQRPNI VQQLQQYQQQ QQHQMSGGQA 780
  781 TGALGQTPNL GKNKHRRVGS SPDNMHPRHP DRITKTTSGS WEIVEKDGES SPPGTPPPPY 840
  841 LSSSHMTVLE DPNENNRGAA AAGPGVFIES HQFTPMAGAS SPIPISLHSS HMHAAQSNDT 900
  901 QKEIISMEDE NSDLDEPFID ENGPFNNLTR LLEAENVTFL AIFLNYVISN SDPAPLLFYL 960
  961 ITELYKEGTS KDMRKWAYEI HSTFLVPRAP LSWYRQDESL AREVDNVLQL EYDKVEILRT1020
 1021 VFLRSRKRAK DLISEQLREF QQKRTAGLGT IYGPTDDKLA EAKTDKLREQ IIDKYLMPNL1080
 1081 HALIEDENGS PPEDVRKVAL CSALSTVIYR IFNTRPPPSS IVERVHHFVS RDKSFKSRIM1140
 1141 GKNRKMNVRG HPLVLRQYYE VTHCNHCQTI IWGVSPQGYH CTDCKLNIHR QCSKVVDESC1200
 1201 PGPLPQAKRL AHNDKISKFM GKIRPRTSDV IGNEKRSRQD EELDVELTPD RGQASIVRQP1260
 1261 SDRRPDANIS IRSNGNTSCN TSGLNTTDLQ SSFHGSCAND SINPGGGAGC NMDLSTSVAS1320
 1321 TTPSTSGSVA AGLSAFAELN ALDTVDKEAR RERYSQHPKH KSAPVSVNRS ESYKERLSNK1380
 1381 RNRNSRRKTS DPSLSSRPND EQLDLGLSNA TYVGSSNSSL SSAGGSESPS TSMEHFAAPG1440
 1441 AAGGVQVPPM GLNQNQHPHL LIQQHAQQYC QQDSFQAGLA GAAGSSAASN SSFWNAGHPL1500
 1501 PVARWTLESE DEDDVNEADW SSMVAAEVLA ALTDAEKKRQ EIINEIYQTE RNHVRTLKLL1560
 1561 DRLFFLPLYE SGLLSQDHLL LLFPPALLSL REIHGAFEQS LKQRRIEHNH VVNTIGDLLA1620
 1621 DMFDGQSGVV LCEFAAQFCA RQQIALEALK EKRNKDEMLQ KLLKKSESHK ACRRLELKDL1680
 1681 LPTVLQRLTK YPLLFENLYK VTVRLLPENT TEAEAIQRAV ESSKRILVEV NQAVKTAEDA1740
 1741 HKLQNIQRKL DRSSYDKEEF KKLDLTQHHL IHDGNLTIKK NPSVQLHGLL FENMIVLLTK1800
 1801 QDDKYYLKNL HTPLSITNKP VSPIMSIDAD TLIRQEAADK NSFFLIKMKT SQMLELRAPS1860
 1861 SSECKTWFKH FSDVAARQSK NRSKNASSNH DTSISDPALA AIPHSNTKES LELSTDTVQP1920
 1921 LAATATLTTT PLAPMLPIAT VTPAPATNNS NVSSLTGVQL RNPQRDATAS ESDADYVNTP1980
 1981 KPRSSQNEVN RTMSIRSTGE PIQKYSANGT EANDVTLRHS QSTRESVRPG STGEERNSTY2040
 2041 GMVGGNSKRD SASIVCSNNS NNTRTLLMQS PLVDPTAIQV SISPAHTAEP VLTPGEKLRR2100
 2101 LDASIRNDLL EKQKIICDIF RLPVEHYDQI VDIAMMPEAP KDSADIALAA YDQIQTLTKM2160
 2161 LNEYMHVTPE QEVSAVSTAV CGHCHEKEKL RKKVAPSSSF SSSPPPLPPP NRQHAQAQAQ2220
 2221 IPPSRLMPKL QTLDLDEVAI HEDDDGYCEI DELRLPAIPS KPHERPTTPL APFNTEPKTS2280
 2281 QSVIDASKRQ STDAVPEGLL EQEPLEGDKT ETKGEDNEVK TVPSDKLSES CNEERQCVEA2340
 2341 DITKEVADPT TSKNEAAASV DELPSQSREI KTAENASKSV ADKKEDNEET IEEGVASTVD2400
 2401 SSTQTSPTES PKETDKLTGG SSSTCGPNRI QHASVLEPSV PCHALSSIVT ILNEQISMLL2460
 2461 PKINERDMER ERLRKENQHL RELLSALHDR QRVDEVKETP FDLKKLMHAE DVEFDDDIDA2520
 2521 ISNSSLTPTP TPIPTASPSA SGQVETAEAM RITSTEDEE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..244] FFAS03 0.966 Microvirus capsid proteins
    2 View Details [245..335] PSI-BLAST 15.39794 No description for 2dlsA was found.
    3 View Details [336..461] deduced N/A No confident structure predictions are available.
    4 View Details [462..631] MSA 1.291993 View MSA. No confident structure predictions are available.
    5 View Details [632..860] deduced N/A No confident structure predictions are available.
    6 View Details [861..1119] PSI-BLAST 35.09691 Pdz-RhoGEF RGS-like domain
    7 View Details [1120..1260] PSI-BLAST 23.0 Crystal Structure of the Human Beta2-Chimaerin
    8 View Details [1261..1452] deduced N/A No confident structure predictions are available.
    9 View Details [1453..1881] PSI-BLAST 82.522879 Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF
    10 View Details [1882..1992] deduced N/A No confident structure predictions are available.
    11 View Details [1993..2060] deduced N/A No confident structure predictions are available.
    12 View Details [2061..2185] deduced N/A No confident structure predictions are available.
    13 View Details [2186..2317] deduced N/A No confident structure predictions are available.
    14 View Details [2318..2419] MSA 1.023993 View MSA. No confident structure predictions are available.
    15 View Details [2420..2559] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • binding
    		•  1.92305667043421 bayes_pls_golite062009
  • armadillo repeat domain binding
    		•  1.35006758459958 bayes_pls_golite062009
  • protein binding
    		•  1.34804002381061 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.31706444263999 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.3121051390771 bayes_pls_golite062009
  • I-SMAD binding
    		•  1.264586411337 bayes_pls_golite062009
  • GTPase activator activity
    		•  1.21906115943903 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.15734063339626 bayes_pls_golite062009
  • enzyme activator activity
    		•  1.1550726111629 bayes_pls_golite062009
  • signal transducer activity
    		•  0.295240519074754 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.295240519074754 bayes_pls_golite062009
  • calmodulin binding
    		•  0.116091476233994 bayes_pls_golite062009
    7
    Term Confidence Notes
  • binding
    		•  2.36195429973813 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.96101710984865 bayes_pls_golite062009
  • myosin heavy chain kinase activity
    		•  0.847021935833721 bayes_pls_golite062009
  • signal transducer activity
    		•  0.406693154533452 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.406693154533452 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.348246993470003 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.0856841905430946 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.0790714288427541 bayes_pls_golite062009
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.
    13 No functions predicted.
    14 No functions predicted.
    15 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle