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View Structure Prediction Details

Protein: RhoGEF2-PD, RhoG...
Organism: Drosophila melanogaster
Length: 2559 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RhoGEF2-PD, RhoG....

Description E-value Query
Range		 Subject
Range
gi|7512000, gi|2... - pir||T09144 probable guanine nucleotide exchange factor RhoGEF2 - fruit fly (Drosophila melanogaster...
 1405.0 [0..1] [2559..1]

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Predicted Domain #1
Region A:
Residues: [1-244] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDPSIKKRL LDLYTDEHEY DEVQEIPEES SIQPPETSTS HTSTNGSSHS GPGTATGPGA  60
   61 TSAGPSAGAP QSPVIVVDSV PELPAPKQKS VKNSKSKQKQ KQLANKSKIP RSPSLASSLS 120
  121 SLASSLSGHR DRDKDRDKDR ENQNAVPPQT PPLPPSYKQN QMNGDSTAAA GGGVSAPATP 180
  181 TTANNNNASH NNGSIMGGGV QLNQSDNSNP VLQAPGERSS LNLTPLSRDL SGGHTQESTT 240
  241 PATT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.966
Match: 1al0G
Description: Microvirus capsid proteins
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [245-335] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSTPSLALPK NFQYLTLTVR KDSNGYGMKV SGDNPVFVES VKPGGAAEIA GLVAGDMILR  60
   61 VNGHEVRLEK HPTVVGLIKA STTVELAVKR S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.39794
Match: 2dlsA
Description: No description for 2dlsA was found.

Predicted Domain #3
Region A:
Residues: [336-461] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKLTRPSSVS VVTPSTPILS GRDRTASITG PQPVDSIKRR EMETYKIQTL QKMLEQEKLN  60
   61 LERLKSDQNN PSYKLSEANI RKLREQLHQV GAEDAPTVKL QAAAGNKNTA LLTPNQIQHL 120
  121 SASATH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [462-631] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNQQFHHLHH HHNLHNNNYP PQQQPASTSP AFLSLLPRSL SSLSLGTRKN KTEKDLTTSS  60
   61 PFGLTTDFLQ QQRMSHQAES MSQSMHQHTS TPTSQQFFHP HQQQHRFKET GPTSKGKNKF 120
  121 LISRSLIEED VPPPLPQRNP PRQLNLDLKN GNASPGGSHL VAPVSDLDRA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [632-860] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSPQLNRSQQ QQLPSSTDNS PSNAKSKRSK IKTKALSDPK MSTQMFLQME SASAAGAAGG  60
   61 SIEVDGGPPP LPPRLPGMMT EDMSRGSCQN LAQPNSVGTA FNYPLVSTTT AVQNDNLNIA 120
  121 FPLSQRPNIV QQLQQYQQQQ QHQMSGGQAT GALGQTPNLG KNKHRRVGSS PDNMHPRHPD 180
  181 RITKTTSGSW EIVEKDGESS PPGTPPPPYL SSSHMTVLED PNENNRGAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [861-1119] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAGPGVFIES HQFTPMAGAS SPIPISLHSS HMHAAQSNDT QKEIISMEDE NSDLDEPFID  60
   61 ENGPFNNLTR LLEAENVTFL AIFLNYVISN SDPAPLLFYL ITELYKEGTS KDMRKWAYEI 120
  121 HSTFLVPRAP LSWYRQDESL AREVDNVLQL EYDKVEILRT VFLRSRKRAK DLISEQLREF 180
  181 QQKRTAGLGT IYGPTDDKLA EAKTDKLREQ IIDKYLMPNL HALIEDENGS PPEDVRKVAL 240
  241 CSALSTVIYR IFNTRPPPS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.09691
Match: 1htjF
Description: Pdz-RhoGEF RGS-like domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.92305667043421 bayes_pls_golite062009
armadillo repeat domain binding 1.35006758459958 bayes_pls_golite062009
protein binding 1.34804002381061 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.31706444263999 bayes_pls_golite062009
GTPase regulator activity 1.3121051390771 bayes_pls_golite062009
I-SMAD binding 1.264586411337 bayes_pls_golite062009
GTPase activator activity 1.21906115943903 bayes_pls_golite062009
enzyme regulator activity 1.15734063339626 bayes_pls_golite062009
enzyme activator activity 1.1550726111629 bayes_pls_golite062009
signal transducer activity 0.295240519074754 bayes_pls_golite062009
molecular transducer activity 0.295240519074754 bayes_pls_golite062009
calmodulin binding 0.116091476233994 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1120-1260] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIVERVHHFV SRDKSFKSRI MGKNRKMNVR GHPLVLRQYY EVTHCNHCQT IIWGVSPQGY  60
   61 HCTDCKLNIH RQCSKVVDES CPGPLPQAKR LAHNDKISKF MGKIRPRTSD VIGNEKRSRQ 120
  121 DEELDVELTP DRGQASIVRQ P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.0
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.36195429973813 bayes_pls_golite062009
protein binding 1.29100556128076 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.96101710984865 bayes_pls_golite062009
myosin heavy chain kinase activity 0.847021935833721 bayes_pls_golite062009
signal transducer activity 0.406693154533452 bayes_pls_golite062009
molecular transducer activity 0.406693154533452 bayes_pls_golite062009
transcription regulator activity 0.348246993470003 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.0856841905430946 bayes_pls_golite062009
GTPase regulator activity 0.0790714288427541 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [1261-1452] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDRRPDANIS IRSNGNTSCN TSGLNTTDLQ SSFHGSCAND SINPGGGAGC NMDLSTSVAS  60
   61 TTPSTSGSVA AGLSAFAELN ALDTVDKEAR RERYSQHPKH KSAPVSVNRS ESYKERLSNK 120
  121 RNRNSRRKTS DPSLSSRPND EQLDLGLSNA TYVGSSNSSL SSAGGSESPS TSMEHFAAPG 180
  181 AAGGVQVPPM GL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1453-1881] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQNQHPHLLI QQHAQQYCQQ DSFQAGLAGA AGSSAASNSS FWNAGHPLPV ARWTLESEDE  60
   61 DDVNEADWSS MVAAEVLAAL TDAEKKRQEI INEIYQTERN HVRTLKLLDR LFFLPLYESG 120
  121 LLSQDHLLLL FPPALLSLRE IHGAFEQSLK QRRIEHNHVV NTIGDLLADM FDGQSGVVLC 180
  181 EFAAQFCARQ QIALEALKEK RNKDEMLQKL LKKSESHKAC RRLELKDLLP TVLQRLTKYP 240
  241 LLFENLYKVT VRLLPENTTE AEAIQRAVES SKRILVEVNQ AVKTAEDAHK LQNIQRKLDR 300
  301 SSYDKEEFKK LDLTQHHLIH DGNLTIKKNP SVQLHGLLFE NMIVLLTKQD DKYYLKNLHT 360
  361 PLSITNKPVS PIMSIDADTL IRQEAADKNS FFLIKMKTSQ MLELRAPSSS ECKTWFKHFS 420
  421 DVAARQSKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 82.522879
Match: 1txdA
Description: Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF
Matching Structure (courtesy of the PDB):

Predicted Domain #10
Region A:
Residues: [1882-1992] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSKNASSNHD TSISDPALAA IPHSNTKESL ELSTDTVQPL AATATLTTTP LAPMLPIATV  60
   61 TPAPATNNSN VSSLTGVQLR NPQRDATASE SDADYVNTPK PRSSQNEVNR T

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1993-2060] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIRSTGEPI QKYSANGTEA NDVTLRHSQS TRESVRPGST GEERNSTYGM VGGNSKRDSA  60
   61 SIVCSNNS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #12
Region A:
Residues: [2061-2185] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNTRTLLMQS PLVDPTAIQV SISPAHTAEP VLTPGEKLRR LDASIRNDLL EKQKIICDIF  60
   61 RLPVEHYDQI VDIAMMPEAP KDSADIALAA YDQIQTLTKM LNEYMHVTPE QEVSAVSTAV 120
  121 CGHCH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #13
Region A:
Residues: [2186-2317] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKEKLRKKVA PSSSFSSSPP PLPPPNRQHA QAQAQIPPSR LMPKLQTLDL DEVAIHEDDD  60
   61 GYCEIDELRL PAIPSKPHER PTTPLAPFNT EPKTSQSVID ASKRQSTDAV PEGLLEQEPL 120
  121 EGDKTETKGE DN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #14
Region A:
Residues: [2318-2419] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVKTVPSDKL SESCNEERQC VEADITKEVA DPTTSKNEAA ASVDELPSQS REIKTAENAS  60
   61 KSVADKKEDN EETIEEGVAS TVDSSTQTSP TESPKETDKL TG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #15
Region A:
Residues: [2420-2559] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSSSTCGPNR IQHASVLEPS VPCHALSSIV TILNEQISML LPKINERDME RERLRKENQH  60
   61 LRELLSALHD RQRVDEVKET PFDLKKLMHA EDVEFDDDID AISNSSLTPT PTPIPTASPS 120
  121 ASGQVETAEA MRITSTEDEE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle