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Protein Overview: RhoGEF2-PE

General Information:
Name(s) found: RhoGEF2-PE / FBpp0086123 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene RhoGEF2 is referred to in FlyBase by the symbol Dmel\RhoGEF2 (CG9635, FBgn0023172). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12914746..12932161. It has the cytological map location 53E4-53F1. Based on sequence similarity, it is predicted to have molecular function</span>: diacylglycerol binding; Rho guanyl-nucleotide exchange factor activity. There is experimental evidence for 14 unique biological process</span> terms, many of which group under: anatomical structure development; regulation of developmental process; organ morphogenesis; regulation of cell morphogenesis; actin filament-based process; organ development; organelle organization; anatomical structure formation involved in morphogenesis; regulation of cellular component organization; reproductive process in a multicellular organism; embryonic development via the syncytial blastoderm; regulation of neurogenesis; cytoskeleton organization. 33 alleles are reported. The phenotypes of these alleles are annotated with: embryonic salivary gland; dorsal mesothoracic disc; embryonic posterior spiracle; epithelial cell; wing; mesoderm anlage; ventral midline. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2205 amino acids

    Gene Ontology:
    Cellular Component: lateral plasma membrane [IDA]
    apical part of cell [IDA]
    actomyosin contractile ring [IDA]
    basal part of cell [IDA]
    apical cortex [IDA]
    apical plasma membrane [IDA]
    actin cap [IDA]
    Biological Process: regulation of cell shape [IDA][IMP]
    ventral furrow formation [IMP]
    regulation of Rho protein signal transduction [IEA]
    spiracle morphogenesis, open tracheal system [IMP]
    posterior midgut invagination [IMP]
    germ-band extension [IMP]
    actin filament organization [IMP]
    anterior midgut invagination [IMP]
    pole cell development [IMP]
    cellularization [IMP]
    gastrulation [TAS]
    regulation of axonogenesis [IGI]
    morphogenesis of embryonic epithelium [IMP]
    regulation of embryonic cell shape [IGI][IMP][NAS]
    actin cytoskeleton reorganization [IMP]
    pseudocleavage during syncytial blastoderm formation [IMP]
    Molecular Function: protein binding [IEA]
    diacylglycerol binding [ISS]
    Rho guanyl-nucleotide exchange factor activity [IEA][ISS][NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDPSIKKRL LDLYTDEHEY DEVQEIPEES SIQPPETSTS HTSTNGSSHS GPGTATGPGA  60
   61 TSAGPSAGAP QSPVIVVDSV PELPAPKQKS VKNSKSKQKQ KQLANKSKIP RSPSLASSLS 120
  121 SLASSLSGHR DRDKDRDKDR ENQNAVPPQT PPLPPSYKQN QMNGDSTAAA GGGVSAPATP 180
  181 TTANNNNASH NNGSIMGGGV QLNQSDNSNP VLQAPGERSS LNLTPLSRDL SGGHTQESTT 240
  241 PATTPSTPSL ALPKNFQYLT LTVRKDSNGY GMKVSGDNPV FVESVKPGGA AEIAGLVAGD 300
  301 MILRVNGHEV RLEKHPTVVG LIKASTTVEL AVKRSQKLTR PSSVSVVTPS TPILSGRDRT 360
  361 ASITGPQPVD SIKRREMETY KIQTLQKMLE QEKLNLERLK SDQNNPSYKL SEANIRKLRE 420
  421 QLHQVGAEAL GQTPNLGKNK HRRVGSSPDN MHPRHPDRIT KTTSGSWEIV EKDGESSPPG 480
  481 TPPPPYLSSS HMTVLEDPNE NNRGAAAAGP GVFIESHQFT PMAGASSPIP ISLHSSHMHA 540
  541 AQSNDTQKEI ISMEDENSDL DEPFIDENGP FNNLTRLLEA ENVTFLAIFL NYVISNSDPA 600
  601 PLLFYLITEL YKEGTSKDMR KWAYEIHSTF LVPRAPLSWY RQDESLAREV DNVLQLEYDK 660
  661 VEILRTVFLR SRKRAKDLIS EQLREFQQKR TAGLGTIYGP TDDKLAEAKT DKLREQIIDK 720
  721 YLMPNLHALI EDENGSPPED VRKVALCSAL STVIYRIFNT RPPPSSIVER VHHFVSRDKS 780
  781 FKSRIMGKNR KMNVRGHPLV LRQYYEVTHC NHCQTIIWGV SPQGYHCTDC KLNIHRQCSK 840
  841 VVDESCPGPL PQAKRLAHND KISKFMGKIR PRTSDVIGNE KRSRQDEELD VELTPDRGQA 900
  901 SIVRQPSDRR PDANISIRSN GNTSCNTSGL NTTDLQSSFH GSCANDSINP GGGAGCNMDL 960
  961 STSVASTTPS TSGSVAAGLS AFAELNALDT VDKEARRERY SQHPKHKSAP VSVNRSESYK1020
 1021 ERLSNKRNRN SRRKTSDPSL SSRPNDEQLD LGLSNATYVG SSNSSLSSAG GSESPSTSME1080
 1081 HFAAPGAAGG VQVPPMGLNQ NQHPHLLIQQ HAQQYCQQDS FQAGLAGAAG SSAASNSSFW1140
 1141 NAGHPLPVAR WTLESEDEDD VNEADWSSMV AAEVLAALTD AEKKRQEIIN EIYQTERNHV1200
 1201 RTLKLLDRLF FLPLYESGLL SQDHLLLLFP PALLSLREIH GAFEQSLKQR RIEHNHVVNT1260
 1261 IGDLLADMFD GQSGVVLCEF AAQFCARQQI ALEALKEKRN KDEMLQKLLK KSESHKACRR1320
 1321 LELKDLLPTV LQRLTKYPLL FENLYKVTVR LLPENTTEAE AIQRAVESSK RILVEVNQAV1380
 1381 KTAEDAHKLQ NIQRKLDRSS YDKEEFKKLD LTQHHLIHDG NLTIKKNPSV QLHGLLFENM1440
 1441 IVLLTKQDDK YYLKNLHTPL SITNKPVSPI MSIDADTLIR QEAADKNSFF LIKMKTSQML1500
 1501 ELRAPSSSEC KTWFKHFSDV AARQSKNRSK NASSNHDTSI SDPALAAIPH SNTKESLELS1560
 1561 TDTVQPLAAT ATLTTTPLAP MLPIATVTPA PATNNSNVSS LTGVQLRNPQ RDATASESDA1620
 1621 DYVNTPKPRS SQNEVNRTMS IRSTGEPIQK YSANGTEAND VTLRHSQSTR ESVRPGSTGE1680
 1681 ERNSTYGMVG GNSKRDSASI VCSNNSNNTR TLLMQSPLVD PTAIQVSISP AHTAEPVLTP1740
 1741 GEKLRRLDAS IRNDLLEKQK IICDIFRLPV EHYDQIVDIA MMPEAPKDSA DIALAAYDQI1800
 1801 QTLTKMLNEY MHVTPEQEVS AVSTAVCGHC HEKEKLRKKV APSSSFSSSP PPLPPPNRQH1860
 1861 AQAQAQIPPS RLMPKLQTLD LDEVAIHEDD DGYCEIDELR LPAIPSKPHE RPTTPLAPFN1920
 1921 TEPKTSQSVI DASKRQSTDA VPEGLLEQEP LEGDKTETKG EDNEVKTVPS DKLSESCNEE1980
 1981 RQCVEADITK EVADPTTSKN EAAASVDELP SQSREIKTAE NASKSVADKK EDNEETIEEG2040
 2041 VASTVDSSTQ TSPTESPKET DKLTGGSSST CGPNRIQHAS VLEPSVPCHA LSSIVTILNE2100
 2101 QISMLLPKIN ERDMERERLR KENQHLRELL SALHDRQRVD EVKETPFDLK KLMHAEDVEF2160
 2161 DDDIDAISNS SLTPTPTPIP TASPSASGQV ETAEAMRITS TEDEE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155] MSA 1.251994 View MSA. No confident structure predictions are available.
    2 View Details [156..470] PSI-BLAST 22.0 solution structure of the split PH-PDZ Supramodule of alpha-Syntrophin
    3 View Details [471..530] deduced N/A No confident structure predictions are available.
    4 View Details [531..692] FFAS03 5.62 Pdz-RhoGEF RGS-like domain
    5 View Details [693..925] PSI-BLAST 20.0 Crystal Structure of the Human Beta2-Chimaerin
    6 View Details [926..1160] deduced N/A No confident structure predictions are available.
    7 View Details [1161..1533] PSI-BLAST 65.09691 Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF
    8 View Details [1534..1636] deduced N/A No confident structure predictions are available.
    9 View Details [1637..1839] deduced N/A No confident structure predictions are available.
    10 View Details [1840..2205] PSI-BLAST 7.154902 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  1.88854883779764 bayes_pls_golite062009
  • protein binding
    		•  1.2613524492191 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.929611177205507 bayes_pls_golite062009
  • I-SMAD binding
    		•  0.928810379477007 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.921253393682362 bayes_pls_golite062009
  • armadillo repeat domain binding
    		•  0.866175697515052 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.846457704342612 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.754288487140305 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.748506389484179 bayes_pls_golite062009
  • signal transducer activity
    		•  0.301823617811642 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.301823617811642 bayes_pls_golite062009
    5
    Term Confidence Notes
  • binding
    		•  2.36195429973813 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.96101710984865 bayes_pls_golite062009
  • myosin heavy chain kinase activity
    		•  0.847021935833721 bayes_pls_golite062009
  • signal transducer activity
    		•  0.406693154533452 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.406693154533452 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.348246993470003 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.0856841905430946 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.0790714288427541 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle