| Protein: | RhoGEF2-PE |
| Organism: | Drosophila melanogaster |
| Length: | 2205 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RhoGEF2-PE.
| Description | E-value | Query Range |
Subject Range |
|
|
1007.0 | [0..429] | [2205..783] |
|
Region A: Residues: [1-155] |
1 11 21 31 41 51
| | | | | |
1 MDDPSIKKRL LDLYTDEHEY DEVQEIPEES SIQPPETSTS HTSTNGSSHS GPGTATGPGA 60
61 TSAGPSAGAP QSPVIVVDSV PELPAPKQKS VKNSKSKQKQ KQLANKSKIP RSPSLASSLS 120
121 SLASSLSGHR DRDKDRDKDR ENQNAVPPQT PPLPP
|
| Detection Method: |  |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [156-470] |
1 11 21 31 41 51
| | | | | |
1 SYKQNQMNGD STAAAGGGVS APATPTTANN NNASHNNGSI MGGGVQLNQS DNSNPVLQAP 60
61 GERSSLNLTP LSRDLSGGHT QESTTPATTP STPSLALPKN FQYLTLTVRK DSNGYGMKVS 120
121 GDNPVFVESV KPGGAAEIAG LVAGDMILRV NGHEVRLEKH PTVVGLIKAS TTVELAVKRS 180
181 QKLTRPSSVS VVTPSTPILS GRDRTASITG PQPVDSIKRR EMETYKIQTL QKMLEQEKLN 240
241 LERLKSDQNN PSYKLSEANI RKLREQLHQV GAEALGQTPN LGKNKHRRVG SSPDNMHPRH 300
301 PDRITKTTSG SWEIV
|
| Detection Method: | |
| Confidence: | 22.0 |
| Match: | 1z87A |
| Description: | solution structure of the split PH-PDZ Supramodule of alpha-Syntrophin |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [471-530] |
1 11 21 31 41 51
| | | | | |
1 EKDGESSPPG TPPPPYLSSS HMTVLEDPNE NNRGAAAAGP GVFIESHQFT PMAGASSPIP 60
61
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [531-692] |
1 11 21 31 41 51
| | | | | |
1 ISLHSSHMHA AQSNDTQKEI ISMEDENSDL DEPFIDENGP FNNLTRLLEA ENVTFLAIFL 60
61 NYVISNSDPA PLLFYLITEL YKEGTSKDMR KWAYEIHSTF LVPRAPLSWY RQDESLAREV 120
121 DNVLQLEYDK VEILRTVFLR SRKRAKDLIS EQLREFQQKR TA
|
| Detection Method: | |
| Confidence: | 5.62 |
| Match: | 1htjF |
| Description: | Pdz-RhoGEF RGS-like domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| binding | 1.88854883779764 | bayes_pls_golite062009 |
| protein binding | 1.2613524492191 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 0.929611177205507 | bayes_pls_golite062009 |
| I-SMAD binding | 0.928810379477007 | bayes_pls_golite062009 |
| GTPase regulator activity | 0.921253393682362 | bayes_pls_golite062009 |
| armadillo repeat domain binding | 0.866175697515052 | bayes_pls_golite062009 |
| enzyme regulator activity | 0.846457704342612 | bayes_pls_golite062009 |
| GTPase activator activity | 0.754288487140305 | bayes_pls_golite062009 |
| enzyme activator activity | 0.748506389484179 | bayes_pls_golite062009 |
| signal transducer activity | 0.301823617811642 | bayes_pls_golite062009 |
| molecular transducer activity | 0.301823617811642 | bayes_pls_golite062009 |
|
Region A: Residues: [693-925] |
1 11 21 31 41 51
| | | | | |
1 GLGTIYGPTD DKLAEAKTDK LREQIIDKYL MPNLHALIED ENGSPPEDVR KVALCSALST 60
61 VIYRIFNTRP PPSSIVERVH HFVSRDKSFK SRIMGKNRKM NVRGHPLVLR QYYEVTHCNH 120
121 CQTIIWGVSP QGYHCTDCKL NIHRQCSKVV DESCPGPLPQ AKRLAHNDKI SKFMGKIRPR 180
181 TSDVIGNEKR SRQDEELDVE LTPDRGQASI VRQPSDRRPD ANISIRSNGN TSC
|
| Detection Method: | |
| Confidence: | 20.0 |
| Match: | 1xa6A |
| Description: | Crystal Structure of the Human Beta2-Chimaerin |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| binding | 2.36195429973813 | bayes_pls_golite062009 |
| protein binding | 1.29100556128076 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 0.96101710984865 | bayes_pls_golite062009 |
| myosin heavy chain kinase activity | 0.847021935833721 | bayes_pls_golite062009 |
| signal transducer activity | 0.406693154533452 | bayes_pls_golite062009 |
| molecular transducer activity | 0.406693154533452 | bayes_pls_golite062009 |
| transcription regulator activity | 0.348246993470003 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 0.0856841905430946 | bayes_pls_golite062009 |
| GTPase regulator activity | 0.0790714288427541 | bayes_pls_golite062009 |
|
Region A: Residues: [926-1160] |
1 11 21 31 41 51
| | | | | |
1 NTSGLNTTDL QSSFHGSCAN DSINPGGGAG CNMDLSTSVA STTPSTSGSV AAGLSAFAEL 60
61 NALDTVDKEA RRERYSQHPK HKSAPVSVNR SESYKERLSN KRNRNSRRKT SDPSLSSRPN 120
121 DEQLDLGLSN ATYVGSSNSS LSSAGGSESP STSMEHFAAP GAAGGVQVPP MGLNQNQHPH 180
181 LLIQQHAQQY CQQDSFQAGL AGAAGSSAAS NSSFWNAGHP LPVARWTLES EDEDD
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1161-1533] |
1 11 21 31 41 51
| | | | | |
1 VNEADWSSMV AAEVLAALTD AEKKRQEIIN EIYQTERNHV RTLKLLDRLF FLPLYESGLL 60
61 SQDHLLLLFP PALLSLREIH GAFEQSLKQR RIEHNHVVNT IGDLLADMFD GQSGVVLCEF 120
121 AAQFCARQQI ALEALKEKRN KDEMLQKLLK KSESHKACRR LELKDLLPTV LQRLTKYPLL 180
181 FENLYKVTVR LLPENTTEAE AIQRAVESSK RILVEVNQAV KTAEDAHKLQ NIQRKLDRSS 240
241 YDKEEFKKLD LTQHHLIHDG NLTIKKNPSV QLHGLLFENM IVLLTKQDDK YYLKNLHTPL 300
301 SITNKPVSPI MSIDADTLIR QEAADKNSFF LIKMKTSQML ELRAPSSSEC KTWFKHFSDV 360
361 AARQSKNRSK NAS
|
| Detection Method: | |
| Confidence: | 65.09691 |
| Match: | 1txdA |
| Description: | Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [1534-1636] |
1 11 21 31 41 51
| | | | | |
1 SNHDTSISDP ALAAIPHSNT KESLELSTDT VQPLAATATL TTTPLAPMLP IATVTPAPAT 60
61 NNSNVSSLTG VQLRNPQRDA TASESDADYV NTPKPRSSQN EVN
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1637-1839] |
1 11 21 31 41 51
| | | | | |
1 RTMSIRSTGE PIQKYSANGT EANDVTLRHS QSTRESVRPG STGEERNSTY GMVGGNSKRD 60
61 SASIVCSNNS NNTRTLLMQS PLVDPTAIQV SISPAHTAEP VLTPGEKLRR LDASIRNDLL 120
121 EKQKIICDIF RLPVEHYDQI VDIAMMPEAP KDSADIALAA YDQIQTLTKM LNEYMHVTPE 180
181 QEVSAVSTAV CGHCHEKEKL RKK
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1840-2205] |
1 11 21 31 41 51
| | | | | |
1 VAPSSSFSSS PPPLPPPNRQ HAQAQAQIPP SRLMPKLQTL DLDEVAIHED DDGYCEIDEL 60
61 RLPAIPSKPH ERPTTPLAPF NTEPKTSQSV IDASKRQSTD AVPEGLLEQE PLEGDKTETK 120
121 GEDNEVKTVP SDKLSESCNE ERQCVEADIT KEVADPTTSK NEAAASVDEL PSQSREIKTA 180
181 ENASKSVADK KEDNEETIEE GVASTVDSST QTSPTESPKE TDKLTGGSSS TCGPNRIQHA 240
241 SVLEPSVPCH ALSSIVTILN EQISMLLPKI NERDMERERL RKENQHLREL LSALHDRQRV 300
301 DEVKETPFDL KKLMHAEDVE FDDDIDAISN SSLTPTPTPI PTASPSASGQ VETAEAMRIT 360
361 STEDEE
|
| Detection Method: | |
| Confidence: | 7.154902 |
| Match: | 1i84S |
| Description: | Heavy meromyosin subfragment |
Matching Structure (courtesy of the PDB): |
|
