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Protein Overview: NiPp1-PA

General Information:
Name(s) found: NiPp1-PA / FBpp0086206 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene Nuclear inhibitor of Protein phosphatase 1 is referred to in FlyBase by the symbol Dmel\NiPp1 (CG8980, FBgn0026402). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12891062..12892604. It has the cytological map location 53E4. There is experimental evidence that it has the molecular function</span>: phosphoprotein phosphatase inhibitor activity; mRNA binding; protein serine/threonine phosphatase inhibitor activity. There is experimental evidence that it is involved in the biological process</span>: axon guidance; negative regulation of protein amino acid dephosphorylation. 4 alleles are reported. The phenotypes of these alleles are annotated with: larval optic neuropil; wing; indirect flight muscle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 383 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    nuclear speck [IDA]
    Biological Process: axon guidance [IMP]
    negative regulation of protein amino acid dephosphorylation [IMP]
    Molecular Function: protein serine/threonine phosphatase inhibitor activity [IDA]
    phosphoprotein phosphatase inhibitor activity [IMP][ISS][NAS]
    mRNA binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANSYDIPSW AGKPPTGLHL DVLKDDKLVQ KLMVDEKRCY LFGRNSQMND FCIDHASCSR  60
   61 VHSAFVYHKH LNIAYLVDLG STHGTFIGTL RLEAHKPTQL QINSTFHFGA STRNYILRER 120
  121 PSGHHSNIME DLPLSETSDG ALLGLPESQT ELDNLTEYNT AHNRRISMLG IDDDTNMRKQ 180
  181 NALKQGRRTR NVTFNDEEIV INPEDVDPNV GRFRNLVQTT VVPAKRARCD VNHMGIHSGN 240
  241 SSLSSANAAH VHQMFQQSLV DMKQQHREMP PPNAVLHSPT NSLYQGLPAE MHGKGDLEPI 300
  301 SPLSIGSKLG LLLPNPAPEV LPVYDEAVET STLAQKLAVA NANVRRFGED PHDSSGEGDS 360
  361 LCPQKKKYAK EAWPGRKPML GQL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..120] PSI-BLAST 28.522879 No description for 2jpeA was found.
    2 View Details [121..192] deduced N/A No confident structure predictions are available.
    3 View Details [193..383] MSA 3.143994 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle