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Protein Overview: Menl-2-PE, Menl-2-PA

General Information:
Name(s) found: Menl-2-PE / FBpp0291082 [FlyBase]
Menl-2-PA / FBpp0100058 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene Menl-2 is referred to in FlyBase by the symbol Dmel\Menl-2 (CG7969, FBgn0029153). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12302320..12306903. It has the cytological map location 53C4. Based on sequence similarity, it is predicted to have molecular function</span>: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: malate metabolic process. No alleles are reported. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene Menl-2 is referred to in FlyBase by the symbol Dmel\Menl-2 (CG7969, FBgn0029153). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12302320..12306903. It has the cytological map location 53C4. Based on sequence similarity, it is predicted to have molecular function</span>: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: malate metabolic process. No alleles are reported. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 600 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: malate metabolic process [IEA]
    Molecular Function: NAD or NADH binding [IEA]
    malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEFRRLHPLL RLASRPLLSS SRRFSVYDDE MEQITRPDWH VVMNGKYNKG LAFTIKERQR  60
   61 LGIMGLMPCS VRSMDDQMNA ALANFEARPT DIARFTYLSA VHHRHRRLYY RFIKENIEKS 120
  121 LPIVYTPTVG DVVATYGLNF QQAISLFISI HDKGHIRDLM HNWVDEGVKA ICVTDGGRVL 180
  181 GLGDMGANAM GISLGKMILY TALGSIPPST LMPVCLDVGT DNQALLQDPL YVGARIPRVK 240
  241 GPEYDELVDE FMESAVKCFG NNTFIHFEDF ATPNALKFLE KYQYKYCCFN DDIQGTGATG 300
  301 LAAFINVERI TGRKLEDTVF LFVGAGSAAL GIANMLAMEL EVRGIPAEEA TKNIYLMDVN 360
  361 GILTPESPNP PEMGKIFIKS MEPMKDMMAV LKKLKPSVLV GATGVGGIFN EEVLKTMAKN 420
  421 HERPAVFPLS NPTANSECTA EQAFTHTEGR VLFGSGSPFP PVVINGKRYR PAQANNCLTF 480
  481 PGIALAAITA KARYLPNEVF SVVSHELARN TPQELLDEGT LFPPIKDAHN VAFNVGVAMT 540
  541 QYLIDNDLSN VYPKPDDICE FVKRSLYKFD YRNSLPTTWD YPVEPPTPKP KTKPKTKPKE 600
  601

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..600] PSI-BLAST 1000.0 Mitochondrial NAD(P)-dependenent malic enzyme

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • malate dehydrogenase activity
    		•  4.38786524125089 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  1.29842732066898 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  1.27032644348698 bayes_pls_golite062009
  • malic enzyme activity
    		•  1.2147813077436 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  1.16811519855038 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  1.01627645289834 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.74536049628503 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  0.729242797855749 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.527946013169731 bayes_pls_golite062009
  • DNA binding
    		•  0.525227236870065 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.459537641913493 bayes_pls_golite062009
  • binding
    		•  0.429102711245135 bayes_pls_golite062009
  • coenzyme binding
    		•  0.35922330382799 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.152651308844322 bayes_pls_golite062009
  • malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
    		•  0.120195861875768 bayes_pls_golite062009
  • glutamate dehydrogenase (NADP+) activity
    		•  0.00742771196951075 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.54

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle