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Protein Overview: Ext2-PB

General Information:
Name(s) found: Ext2-PB / FBpp0099953 [FlyBase]
Description(s) found:
Found 36 descriptions.
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  • The gene Ext2 is referred to in FlyBase by the symbol Dmel\Ext2 (CG8433, FBgn0029175). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12033411..12037121. It has the cytological map location 52E11. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: decapentaplegic receptor signaling pathway; smoothened signaling pathway; chondroitin sulfate biosynthetic process; glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; Wnt receptor signaling pathway; heparin biosynthetic process; heparan sulfate proteoglycan biosynthetic process. 15 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 717 amino acids

    Gene Ontology:
    Cellular Component: Golgi apparatus [IDA]
    endoplasmic reticulum [IDA]
    intrinsic to endoplasmic reticulum membrane [IEA]
    Biological Process: chondroitin sulfate biosynthetic process [IMP]
    heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [IMP]
    heparan sulfate proteoglycan biosynthetic process [IDA][NAS]
    glycosaminoglycan biosynthetic process [IMP]
    Wnt receptor signaling pathway [IMP]
    smoothened signaling pathway [IMP]
    N-acetylglucosamine metabolic process [ISS]
    decapentaplegic receptor signaling pathway [IMP]
    heparin biosynthetic process [IMP]
    Molecular Function: protein binding [IPI]
    acetylglucosaminyltransferase activity [ISS][NAS]
    glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [ISS]
    glucuronosyltransferase activity [NAS]
    N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKIKNLLSF VTQSRAISHT NPREHILNCL TYGLLVIVAL CAGFLLWDLS SSPRDGFFHG  60
   61 KRDSHTLILD LEHIQELAVN PEAEQRARNV NCTFWDCLNI YKCEHDRLKV YIYPLQEFVD 120
  121 EQSDKTATTL SSEYFQILEA VLKSRYYTSN PNEACLFLPS LDLLNQNVFD KHLAGAALAS 180
  181 LDFWDRGANH IIFNMLPGGA PSYNTVLDVN TDNAIIFGGG FDSWSYRPGF DVAIPVWSPR 240
  241 LVRQHAHATA QRKFLLVVAQ LNILPRFVRT LRELSLAHSE QLLLLGACEN LDLTMRCPLS 300
  301 QHHKSLEYPR LLSRGKFCLL GRSLRMGQPD LVEIMSQHCI PVIAVDNYVL PFEDVIDWSL 360
  361 ASVRIRENEL HSVMQKLKAI SSVKIVEMQK QVQWLFSKYF KDLKTVTLTA LEVLESRIFP 420
  421 LRARSSRQWN TIDTNARSTF NPLFLPSLAP KSQGFTAVIL TYDRVESLFL LIQKLAVVPS 480
  481 LQSILVIWNN QKKSPPHLST FPSISKPLKI RQTKENKLSN RFYPYPEIET EAILTIDDDI 540
  541 IMLTTDELDF GYEVWREFPD HIVGFPSRIH VWENVTMRWH YESEWTNQIS MVLTGAAFHH 600
  601 KYWSHMYTHA MPGDIKDWVD EHMNCEDIAM NFLVANITNN PPIKVTPRKK FKCPECTNTE 660
  661 MLSADLNHMR ERSACIDRFS KIYGRMPLRT VEFRADPVLF RDNFPDKLKR YNDIGSL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] deduced N/A No confident structure predictions are available.
    2 View Details [97..248] Pfam 5.853872 No description for PF03016.6 was found. No confident structure predictions are available.
    3 View Details [249..437] FFAS03 0.951 No description for 2nzwA was found.
    4 View Details [438..717] PSI-BLAST 87.522879 Alpha-1,4-N-acetylhexosaminyltransferase (Alpha-GalNAcT EXTL2)


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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