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Protein Overview: spin-PA

General Information:
Name(s) found: spin-PA / FBpp0088552 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene spinster is referred to in FlyBase by the symbol Dmel\spin (CG8428, FBgn0086676). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12012488..12025743. It has the cytological map location 52E6-52E. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: endosome to lysosome transport; regulation of programmed cell death; endocytosis; locomotion; larval central nervous system remodeling; synaptic vesicle endocytosis; regulation of nurse cell apoptosis; oogenesis; regulation of synaptic growth at neuromuscular junction; regulation of female receptivity. 62 alleles are reported. The phenotypes of these alleles are annotated with: embryonic head; retina; medulla; adult central nervous system; neuromuscular junction; embryonic peripheral nervous system; embryonic central nervous system; egg chamber; endosome; adult brain. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 605 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [NAS]
    Biological Process: regulation of female receptivity [IMP]
    transmembrane transport [IEA]
    locomotion [IMP]
    regulation of synaptic growth at neuromuscular junction [IMP]
    peripheral nervous system development [NAS]
    regulation of programmed cell death [IMP]
    endosome to lysosome transport [IMP]
    regulation of nurse cell apoptosis [IMP]
    larval central nervous system remodeling [IMP]
    endocytosis [IMP]
    oogenesis [IMP]
    synaptic vesicle endocytosis [IMP]
    courtship behavior [NAS]
    programmed cell death [NAS]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLKHQKQSY QPLPTAAAMD NPAMIQSSGS SGSSSSEEGG SREDVANLSP LGLPTTYSSQ  60
   61 QLMPSDTDSM EEERHRLRPH HHHHHPLGEH HHIPGIPPSA VVPSRLSSVG RSQWFTVTVL 120
  121 CFVNLINYMD RFTIAGVLTD VRNDFDIGND SAGLLQTVFV ISYMVCAPIF GYLGDRYSRP 180
  181 WIMAVGVGLW STTTLLGSFM KQFGWFIAFR ALVGIGEASY STIAPTIISD LFVHDMRSKM 240
  241 LALFYFAIPV GSGLGYIVGS KTAHLANDWR WALRVTPILG IVAVFLILLI KDPVRGHSEG 300
  301 SHNLEATTYK QDIKALVRNR SFMLSTAGFT CVAFVAGALA WWGPSFIYLG MKMQPGNENI 360
  361 VQDDVAFNFG VITMLAGLLG VPLGSFLSQY LVKRYPTADP VICAFGLLVS APLLTGACLL 420
  421 VNSNSVGTYA LIFFGQLALN LNWAIVADIL LYVVVPTRRS TAEAFQILIS HALGDAGSPY 480
  481 LVGAISEAIM KHLHKNPSDS GLTTELRSMS QVAGSAISNA TQVIAEATTS LMETARSSAS 540
  541 QEYSDVEQFE GLQYALFSTS FVEVLGGIFF IFTACFIIKD KYNATRGLQD ATAQQQQRDE 600
  601 RGQIA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..95] FFAS03 1.01 Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5h)
    2 View Details [96..605] PSI-BLAST 41.0 Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.59744164024479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.54194478414824 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.21266150105753 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.79369588808394 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • binding
    		•  1.25550149366993 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.812001619402678 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  0.143419068761182 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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