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Protein Overview: unc-5-PA, FBpp03...

General Information:
Name(s) found: FBpp0309017 [FlyBase]
unc-5-PA / FBpp0086514 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • type=protein; loc=2R:join(11244533..11245217,11245514..11245795,11246084..11246254,11247920..11247973,11249488..11249805,11252018..11252146,11252251..11252443,11253216..11253289,11253348..11254660); ID=FBpp0309017; name=unc-5-PB; parent=FBgn0034013,FBtr0339998; dbxref=FlyBase:FBpp0309017,FlyBase_Annotation_IDs:CG8166-PB; MD5=af7c677edbed4c571bd3a8203477e15f; length=1072; release=r5.56; species=Dmel; [FlyBase]
  • The gene unc-5 is referred to in FlyBase by the symbol Dmel\unc-5 (CG8166, FBgn0034013). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:11237659..11255807. It has the cytological map location 51F9-51F11. Based on sequence similarity, it is predicted to have molecular function</span>: repulsive netrin receptor activity; netrin receptor activity. There is experimental evidence that it is involved in the biological process</span>: motor axon guidance; salivary gland boundary specification; axon guidance; glial cell migration. 20 alleles are reported. The phenotypes of these alleles are annotated with: embryonic salivary gland; ventral nerve cord; posterior commissure; intersegmental nerve; interface glial cell; abdominal segmental nerve; embryonic neuron; anterior commissure. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1072 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: motor axon guidance [IMP]
    signal transduction [IEA]
    salivary gland boundary specification [IMP]
    axon guidance [IGI][IMP]
    glial cell migration [IMP]
    Molecular Function: protein binding [IEA]
    netrin receptor activity [ISS]
    repulsive netrin receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVINKAGNV IALLLVKLQL ILLFTLSVSG ELPQLDYGSL SASLEEDAID PLTAMAPFAN  60
   61 SLVTEESAQH KNNAELLGNS SEDENVRPQQ GSSSSGLGSS GAAGGSGILL EEFNSGKLSP 120
  121 GEASNTLPIF LIEPESVFVV KNRPAVLKCK ASHSLQVIFK CSGSSQPPPS THETHVDPHT 180
  181 GVNMEEVTAT IHRDLVDEFF GDGPFKCECH AWSSRGVVKS QAATVHIAYI RKSFNQSPTS 240
  241 LRLELGSRAE LRCEPPGGFP EPKLTWHKNN AVITADSEPG ITVSAGTLIF RQVALQHMAN 300
  301 YSCSAENIAG RRVSDSAVLI VYVNGGWSTW SPWRECKCAG KPSQGRKRSR TCNNPMPLNG 360
  361 GAQCPGPQIQ KSADCAACPE DTQIVSPDGF DISSSKRMAR WSAWSDWSIC SAECIQVRRR 420
  421 KCLTQGQTQI SSEAEEAGDL LLGAPGVGMA ALIAAAGVGA VGSPSEATGS SSDIIPGYGK 480
  481 SLCAGKDIQT AECRGEQCQI GKDDFDWTLY LGLAFITAVC FAFGTALICC ARRGIRTNPH 540
  541 YNMARSVMDA DYMPGVVEKK EMRMHIEASN MGYDYVNPGH RYLPGEHIMG MGIGCGGVTE 600
  601 HHYDVPNLSA NYTNPIDHLS VDYLSETGES STADTSNSTF DMNGKLSILN ASKSSTYEML 660
  661 GSAGGQLRLY GGELLLFVPE HAIGKHVKKH VSLLLLSDEC SRVSCATESS ILCSSVVHSA 720
  721 PRNYSFVKPV ILKIPHCLVA PEQWHVHIYH ADSEHDELSV NWRRAVSVGE ETINTPMFVQ 780
  781 LEATHVFIMT EQLGHFTVVA EPRIQQPSIK MKLLAFSQHT PPSNANCSLR IYVVKDFPNS 840
  841 RDICANVEAK LGGSFLGESQ VFAFTLNSRN LNIRVRSADV EAAAPYEHAI PYQHILSNNS 900
  901 ILHCEFSLRR QDQNSLCVDF GQGSEDDYYT FNIPAHSMSG SAEELASTTN TTISIDRQGN 960
  961 YVNESCVMDF VQLPHATKRL ICGALDPPRA DERDWRLLAK KLNTDRYIAY FATKASPTEQ1020
 1021 ILNLWECRAN SSPGSSSNSV SHTIMALLLT LKEMGRQDVL DIIVETIGPL WI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..233] PSI-BLAST 31.0 No description for 2v9qA was found.
    2 View Details [234..602] PSI-BLAST 27.522879 Solution structure of dimeric form of properdin by X-ray solution scattering and analytical ultracentrifugation
    3 View Details [603..819] MSA 1.238981 View MSA. No confident structure predictions are available.
    4 View Details [820..936] deduced N/A No confident structure predictions are available.
    5 View Details [937..1072] PSI-BLAST 33.522879 Crystal structure of the UNC5H2 death domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  2.81925838257497 bayes_pls_golite062009
  • protein binding
    		•  2.45473206123776 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.79234496253717 bayes_pls_golite062009
  • receptor activity
    		•  1.73411211759611 bayes_pls_golite062009
  • signal transducer activity
    		•  1.48908901984354 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.48908901984354 bayes_pls_golite062009
  • netrin receptor activity
    		•  1.19822565953592 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.8302342819454 bayes_pls_golite062009
  • cytokine binding
    		•  0.34960245851041 bayes_pls_golite062009
  • death receptor activity
    		•  0.15603114432983 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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