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Protein Overview: Sox15-PA

General Information:
Name(s) found: Sox15-PA / FBpp0086702 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Sox box protein 15 is referred to in FlyBase by the symbol Dmel\Sox15 (CG8404, FBgn0005613). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10088888..10099914. It has the cytological map location 50E4. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: bristle development; wing disc development; negative regulation of transcription; negative regulation of apoptosis; negative regulation of cell proliferation. 11 alleles are reported. The phenotypes of these alleles are annotated with: mechanosensory chaeta; wing sclerite; eo dendrite; wing blade; wing hinge primordium; tormogen cell; alula; joint; wing hinge. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 784 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: wing disc development [IGI][IMP]
    negative regulation of cell proliferation [IMP]
    negative regulation of apoptosis [IMP]
    negative regulation of transcription [IMP]
    bristle development [IGI][IMP]
    regulation of transcription [ISS]
    Molecular Function: transcription factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPSYDHEHP HHLLTNYNSK KYPHVSRTPE YSHSTGSDYP EHGGYLTDGR LMHESNSDAG  60
   61 IYHVRQGSEH SSPSLHSPAI QSSGYENEHL NEAVLAAHSH SHSPMPMVSS AYVGGGTASG 120
  121 SLINSNIPLL GGGGNSVLNK FLSHPHAGMV GGGTGQMEDC TSHSPIEAAS MWSYDYKGDL 180
  181 CAPNCGYLER HKPLPADLKY RPGGTQSKSA KESRIRRPMN AFMVWAKIER KKLADENPDL 240
  241 HNADLSKMLG KKWRSLTPQD RRPYVEEAER LRVIHMTEHP NYKYRPRRRK QSKLRAMQPG 300
  301 GKEQSESSPN PGTGGSKSNP KLATPPLATA SSSYTTPTDE STCNSTNQNH GQSTPGGLYE 360
  361 QPLKPTYSPS SVDCYSNADS TEQIESLAAN CPPALLNESS PTGGGYDNSL LLKKLTKPSP 420
  421 SRAAKSRQEK LAKSEEKNKG SQSQGQSQQG IYAATYPLAP TSVAVVAARG MYVTCNNRGL 480
  481 LDHGHSVKGT FYPPVSVSED DNSTSMRNSI SALQQHCNVV TSTPSSSGGT MPTSEMSSYT 540
  541 VSMADNCGNL RLSMNELSGN EYLPSANAYG MQYEDFLRYQ SNDMDYSTSA VEHKETTSDS 600
  601 ASGQKCLKYP DTNQNYDDYE AEAYSNAMLP ATAASYYTQL PYPPTSLAAF PLQLAVPFQQ 660
  661 TTSGAYGAQP IQSGYLHYGN YGGYEGMAQS QPQNQAPVHH QQASHSAPPS LSVPPNQTVT 720
  721 SNSAAISMQQ HHHHHFGPAP GMVGVGVGVG VGVGVGEMLF EQQQRKDDEI SNILAGVRKT 780
  781 CYSN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..134] deduced N/A No confident structure predictions are available.
    2 View Details [135..298] PSI-BLAST 14.69897 TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
    3 View Details [299..390] FFAS03 1.22 Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
    4 View Details [391..490] deduced N/A No confident structure predictions are available.
    5 View Details [491..614] PSI-BLAST 3.30103 Sec24
    6 View Details [615..784] FFAS03 1.0 Hyaluronate lyase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA binding
    		•  5.15324651287773 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.9607192917135 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.70730250099648 bayes_pls_golite062009
  • transcription factor activity
    		•  3.82658263870186 bayes_pls_golite062009
  • binding
    		•  3.6211482127468 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.96229555092695 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.84606709725198 bayes_pls_golite062009
  • transcription activator activity
    		•  1.62744929149746 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.53825678633232 bayes_pls_golite062009
  • protein binding
    		•  1.131658134984 bayes_pls_golite062009
  • transcription factor binding
    		•  1.10315330167937 bayes_pls_golite062009
  • DNA bending activity
    		•  0.87985209274756 bayes_pls_golite062009
  • chromatin binding
    		•  0.830960835937769 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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