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Protein Overview: CG13343-PA

General Information:
Name(s) found: CG13343-PA / FBpp0086711 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG13343 (CG13343, FBgn0033882). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9746462..9747942. It has the cytological map location 50C6. Based on sequence similarity, it is predicted to have molecular function</span>: NEDD8 ligase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: protein neddylation. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 450 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: protein neddylation [IEA]
    Molecular Function: ATP binding [IEA]
    small protein activating enzyme activity [IEA]
    NEDD8 ligase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVHSPNPGL ILQSKRFNGL RNILEREGPF CKDGFAASSE NLEFLQTKCQ VLIIGAGGLG  60
   61 CELLKDLALM GFGNLHVIDM DTIELSNLNR QFLFRRTDIG ASKAECAARF INARVPTCRV 120
  121 TPHFKKIQDF DESFYQQFHL VVCGLDSIVA RRWINGMLLS MLRYEEDGTI DTSSIVPMID 180
  181 GGTEGFKGNA RVILPGFTAC IECTLDLFPP QVNYPLCTIA NTPRLPEHCI EYVKIIQWEK 240
  241 QNPFGVPLDG DDPQHIGWIY ERALERSNEF NITGVTYRLV QGVVKHIIPA VASTNAAIAA 300
  301 ACALEVFKLA TSCYDSMANY LNFNDLDGIY TYTYEAEKSE NCLACSNTPQ PLPIEDPNTT 360
  361 TLEDVIKLLC DSPRFQLKSP ALTTVMKDGK RRTLYMSGVK SIEEATRKNL TQSLGELGLH 420
  421 DGQQLTVTDA TSPSAMTLQL KYQSNEVEMV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..450] PSI-BLAST 112.0 Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • small protein activating enzyme activity
    		•  5.883593664369 bayes_pls_golite062009
  • NEDD8 activating enzyme activity
    		•  4.6334061288737 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.34092044533955 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.84216910649062 bayes_pls_golite062009
  • binding
    		•  1.66028321721112 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.42083903479203 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.31244773198273 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.27535252106053 bayes_pls_golite062009
  • catalytic activity
    		•  1.22201444897049 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  1.11310449351601 bayes_pls_golite062009
  • transferase activity
    		•  0.680338489823338 bayes_pls_golite062009
  • protein binding
    		•  0.358621954748546 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.302798969355962 bayes_pls_golite062009
  • URM1 activating enzyme activity
    		•  0.207228630005671 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle