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Protein Overview: Spt-I-PC, Spt-I-...

General Information:
Name(s) found: Spt-I-PC / FBpp0086844 [FlyBase]
Spt-I-PA / FBpp0086843 [FlyBase]
Spt-I-PB / FBpp0086842 [FlyBase]
Description(s) found:
Found 48 descriptions.
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  • The gene Serine palmitoyltransferase subunit I is referred to in FlyBase by the symbol Dmel\Spt-I (CG4016, FBgn0086532). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9056005..9058249. It has the cytological map location 49F4. Based on sequence similarity, it is predicted to have molecular function</span>: serine C-palmitoyltransferase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: biosynthetic process. 6 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Serine palmitoyltransferase subunit I is referred to in FlyBase by the symbol Dmel\Spt-I (CG4016, FBgn0086532). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9056005..9058249. It has the cytological map location 49F4. Based on sequence similarity, it is predicted to have molecular function</span>: serine C-palmitoyltransferase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: biosynthetic process. 6 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Serine palmitoyltransferase subunit I is referred to in FlyBase by the symbol Dmel\Spt-I (CG4016, FBgn0086532). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9056005..9058249. It has the cytological map location 49F4. Based on sequence similarity, it is predicted to have molecular function</span>: serine C-palmitoyltransferase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: biosynthetic process. 6 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 468 amino acids

    Gene Ontology:
    Cellular Component: serine C-palmitoyltransferase complex [ISS]
    Biological Process: biosynthetic process [IEA]
    Molecular Function: pyridoxal phosphate binding [IEA]
    transferase activity, transferring nitrogenous groups [IEA]
    serine C-palmitoyltransferase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAIQLFNEI GSIFRNTPTF ALVLETLLLI TVIWLLLHRR GGGRRRQLTK EEEDRIIADY  60
   61 EPEPLVADTD PNHPLLHTRV VQSRVGKRIQ VDGHDCLNLG SHNYLGFLED QEILEEACKS 120
  121 LRKYGVGSCG PRGFYGTMDV HLDLEDRIAK FMGLEEAIVY SYGFSTVASA IPAYAKRGDL 180
  181 IFVDEAVNFA IQKGLDASRS TIVFFKHNDV EDLERLLIEQ EKRDQKNPKK AAKTRRFLVA 240
  241 EGIYMNTGEI CPLPDLVALR QKYKLRLFID ESISFGTLGQ GGHGVTEHFN VDRDEVDLIS 300
  301 AGMEGSMATV GGFCVGSHFI AEHQRLSGLG YIFSASLPPM LTQAAISALD RFEREPQIFE 360
  361 QLQAKSKTLH QKFLRFSKLT LRGDEVSPVK HLYLAQPAEN FDKELKLLTE LADKCIARGV 420
  421 AVVQAAYLQN RERQPVRPSI RIAVNRLLES SEIDNAFEVI ESVSSSVL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..468] PSI-BLAST 81.69897 2-amino-3-ketobutyrate CoA ligase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • serine C-palmitoyltransferase activity
    		•  9.1839236553858 bayes_pls_golite062009
  • C-palmitoyltransferase activity
    		•  9.1839236553858 bayes_pls_golite062009
  • C-acyltransferase activity
    		•  4.29379571948906 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  2.82458180884712 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • threonine aldolase activity
    		•  1.80396420390785 bayes_pls_golite062009
  • adenosylmethionine-8-amino-7-oxononanoate transaminase activity
    		•  1.60594586591965 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  1.46601963907552 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  1.46601963907552 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07873942461292 bayes_pls_golite062009
  • glycine C-acetyltransferase activity
    		•  0.935794708043259 bayes_pls_golite062009
  • DNA binding
    		•  0.886628214497634 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.814403324199462 bayes_pls_golite062009
  • structural molecule activity
    		•  0.811208803619077 bayes_pls_golite062009
  • transferase activity
    		•  0.737426388870721 bayes_pls_golite062009
  • carbon-sulfur lyase activity
    		•  0.698312655247044 bayes_pls_golite062009
  • binding
    		•  0.661198018681765 bayes_pls_golite062009
  • transcription factor activity
    		•  0.615294010373048 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  0.54326874956263 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.319452731970428 bayes_pls_golite062009
  • sulfurtransferase activity
    		•  0.0450490929307473 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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