Protein Overview: lola-PC, lola-PB

General Information:
Name(s) found:	lola-PC / FBpp0088379 [FlyBase] lola-PB / FBpp0088377 [FlyBase]
Description(s) found: Found 38 descriptions. SHOW ALL	The gene longitudinals lacking is referred to in FlyBase by the symbol Dmel\lola (CG12052, FBgn0005630). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6369712..6430767. It has the cytological map location 47A11-47A13. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: anatomical structure development; cell projection organization; cellular component movement; behavior; sensory organ development; organ morphogenesis; immune response; programmed cell death; neuromuscular process; behavioral interaction between organisms; locomotory behavior; regulation of metabolic process. 163 alleles are reported. The phenotypes of these alleles are annotated with 40 unique terms, many of which group under: peripheral nervous system; nervous system; abdominal lateral monoscolopidial chordotonal organ lch1; embryonic neuron; embryonic nervous system; organ system; multi-cell-component structure; adult segment; abdominal longitudinal muscle; ventral longitudinal muscle. It has 26 annotated transcripts and 26 annotated polypeptides. [FlyBase] The gene longitudinals lacking is referred to in FlyBase by the symbol Dmel\lola (CG12052, FBgn0005630). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6369712..6430767. It has the cytological map location 47A11-47A13. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: anatomical structure development; cell projection organization; cellular component movement; behavior; sensory organ development; organ morphogenesis; immune response; programmed cell death; neuromuscular process; behavioral interaction between organisms; locomotory behavior; regulation of metabolic process. 163 alleles are reported. The phenotypes of these alleles are annotated with 40 unique terms, many of which group under: peripheral nervous system; nervous system; abdominal lateral monoscolopidial chordotonal organ lch1; embryonic neuron; embryonic nervous system; organ system; multi-cell-component structure; adult segment; abdominal longitudinal muscle; ventral longitudinal muscle. It has 26 annotated transcripts and 26 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	787 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][NAS]
Biological Process:	regulation of gene-specific transcription [IMP] R7 cell development [IMP] axon guidance [IGI][IMP][NAS] nurse cell apoptosis [IMP] brain morphogenesis [IMP] R3/R4 cell fate commitment [IMP] inter-male aggressive behavior [IMP] regulation of transcription from RNA polymerase II promoter [NAS] locomotion involved in locomotory behavior [IMP] startle response [IMP] positive regulation of transcription, DNA-dependent [ISS] axonogenesis [IMP] axon midline choice point recognition [IGI][IMP] antimicrobial humoral response [IMP]
Molecular Function:	zinc ion binding [IEA] protein binding [IPI] RNA polymerase II transcription factor activity [NAS] specific RNA polymerase II transcription factor activity [ISS][NAS] transcription activator activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDDQQFCLR WNNHQSTLIS VFDTLLENET LVDCTLAAEG KFLKAHKVVL SACSPYFATL  60
   61 LQEQYDKHPI FILKDVKYQE LRAMMDYMYR GEVNISQDQL AALLKAAESL QIKGLSDNRT 120
  121 GGGVAPKPES SGHHRGGKLS GAYTLEQTKR ARLATGGAMD TSGDVSGSRE GSSSPSRRRR 180
  181 KVRRRSMEND AHDNSNSSVL QAAASNQSIL QQTGAGLAVS ALVTTQLSSG PAAGTSSQAS 240
  241 STQQQQPLTS TNVTKKTESA KLTSSTAAPA SGASASAAVQ QAHLHQQQAQ TTSDAINTEN 300
  301 VQAQSQGGAQ GVQGDDEDID EGSAVGGPNS ATGPNPASAS ASAVHAGVVV KQLASVVDKS 360
  361 SSNHKHKIKD NSVSSVGSEM VIEPKAEYDD DAHDENVEDL TLDEEDMTME ELDQTAGTSQ 420
  421 GGEGSSQTYA TWQHDRSQDE LGLMAQDAQQ RDPQDLSITR IAGLTWNEWN ARLAMPLVTL 480
  481 REGVQPLVFP TDLSVDKQQG AAGLTAKDVN VSGRKTPTDG GGCKSEPRAA STPARTHSSS 540
  541 NHSSNGNGSG KPTKTSSGGK LNHLTEEEAT ALMLKAVAEK QAAAAAGTEL SFGEDQASSG 600
  601 NGNSSDYPAT LSGAVTFADV GGPAGLCHIN ILNSISAMNN LISGSTAAGV GITTGSGQSP 660
  661 SNSGHNNSAG GGSSVLGGAD NGAGHPCPVC GRVYKLKSSL RNHQKWECGK EPQFQCPFCV 720
  721 YRAKQKMHIG RHMERMHKEK FKLEDVKNFA GSSGLDGDSS GATATAASVV AAAAALVSGV 780
  781 ELHPHFS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..179]	PSI-BLAST	34.522879	No description for 2nn2A was found.
2	View Details	[180..346]	deduced	N/A	No confident structure predictions are available.
3	View Details	[347..496]	MSA	1.636985	View MSA. No confident structure predictions are available.
4	View Details	[497..619]	deduced	N/A	No confident structure predictions are available.
5	View Details	[620..787]	PSI-BLAST	44.69897	No description for 2i13A was found.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.66

Protein Overview: lola-PC, lola-PB

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: