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Protein Overview: Pkn-PF

General Information:
Name(s) found: Pkn-PF / FBpp0087684 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Protein kinase related to protein kinase N is referred to in FlyBase by the symbol Dmel\Pkn (CG2049, FBgn0020621). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5139815..5172602. It has the cytological map location 45C1. There is experimental evidence that it has the molecular function</span>: protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: dorsal closure. 44 alleles are reported. The phenotypes of these alleles are annotated with: dorsal closure embryo; anterior wing margin; wing margin bristle; posterior wing margin; wing; ommatidium; wing hair. It has 10 annotated transcripts and 10 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1205 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: dorsal closure [IMP][TAS]
    signal transduction [IEA]
    protein amino acid phosphorylation [ISS][NAS]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [IDA]
    protein serine/threonine kinase activity [ISS][NAS]
    protein kinase C activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALTMNMVFL KDLRSRLKGY LHGEYIKHPV LYELSHKYGF TENLPESCMS IRLEEIKEAI  60
   61 RREIRKELKI KEGAEKLREV AKDRRSLSDV AVLVKKSKSK LAELKSELQE LESQILLTSA 120
  121 NTAVNSNGQE SITACIDPNG GFLVSGAVGG LGGGNTALEG GAPATANDKV LASLEKQLQI 180
  181 EMKVKTGAEN MIQSLGIGCD KKLLAEAHQM LADSKAKIEF LRLRIIKVKQ NREQADRLKA 240
  241 SRQMIDEHGQ TIGGNNSSQP QSLETTLEER IEELRHRLRI EAAVVDGAKN VIRTLQTANR 300
  301 APDKKALQEA HGRLSESSRK LDLLRYSLDL RRQELPADSP AAQQLKTELQ IVQLSTSPAP 360
  361 VTYTSLQSGQ AGILGGKPYQ SVSSLGRCAS VTGKLEVRLL GCQDLLEDVP GRSRRDKDNN 420
  421 SSPGDLRSFV KGVTSRSSSK SYSVKDETSI EIMAVIKLDN ITVGQTSWKQ CSQQAWDQRF 480
  481 SIDLDRSREL EIGVYWRDWR SLCAVKVLRL EEFIDDVRHG MALQLEPQGL LFAEVKFLNP 540
  541 MISQKPKLRR QRMIFNRQQA KNISRAKQMN INVATWGRLL KRNAPNHVHM GSAGSGSSLT 600
  601 GSSPMVVGGS RDSESPISRT PSSDALVEPE PYTPGEQAQN LEFDPDAGIN EHVETPGEYP 660
  661 DPAASGLSGM RPLSMHMQGI SVLPPESPPV ATGAAGRPNT LSLQMPGASK GQVIQGGRTA 720
  721 APTTAPPPPP VLKATSTTPI LDQEVIPQLG KLYVGSSQQQ YAQQSSPIIQ EPATPTIYGN 780
  781 SAAAGAPQFP QPAQRQEKQP PQQQPIYANQ YELNVAKAAA AASVYSPSSS TTSNSNQQQQ 840
  841 QQRRNVARGL QYRESGGLET GRAGKQPPNA GMLSMDNFRL LSVLGRGHFG KVILSQLRSN 900
  901 NQYYAIKALK KGDIIARDEV ESLLSEKRIF EVANAMRHPF LVNLYSCFQT EQHVCFVMEY 960
  961 AAGGDLMMHI HTDVFLEPRA VFYAACVVLG LQYLHENKII YRDLKLDNLL LDTEGYVKIA1020
 1021 DFGLCKEGMG FGDRTGTFCG TPEFLAPEVL TETSYTRAVD WWGLGVLIFE MLVGESPFPG1080
 1081 DDEEEVFDSI VNDEVRYPRF LSLEAIAVMR RLLRKNPERR LGSSERDAED VKKQAFFRSI1140
 1141 VWDDLLLRKV KPPFVPTINH LEDVSNFDEE FTSEKAQLTP PKEPRHLTEE EQLLFQDFSY1200
 1201 TAEWC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..354] PSI-BLAST 24.09691 Heavy meromyosin subfragment
    2 View Details [355..420] deduced N/A No confident structure predictions are available.
    3 View Details [421..610] PSI-BLAST 18.522879 Domain from protein kinase C epsilon
    4 View Details [611..1139] PSI-BLAST 55.39794 No description for 2h8hA was found.
    5 View Details [1140..1205] PSI-BLAST 101.0 No description for 2jdoA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • calcium-dependent phospholipid binding
    		•  3.93415448210371 bayes_pls_golite062009
  • binding
    		•  2.77482286467294 bayes_pls_golite062009
  • phospholipid binding
    		•  2.74013385479058 bayes_pls_golite062009
  • neurexin binding
    		•  1.99616093461872 bayes_pls_golite062009
  • lipid binding
    		•  1.79802914584378 bayes_pls_golite062009
  • protein binding
    		•  1.33917246836907 bayes_pls_golite062009
  • receptor activity
    		•  1.33810899162617 bayes_pls_golite062009
  • transporter activity
    		•  1.2628067945512 bayes_pls_golite062009
  • signal transducer activity
    		•  1.10701462579828 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.10701462579828 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.816751946072324 bayes_pls_golite062009
  • SNARE binding
    		•  0.3731056408292 bayes_pls_golite062009
  • profilin binding
    		•  0.32399339703241 bayes_pls_golite062009
  • syntaxin-1 binding
    		•  0.273890767897551 bayes_pls_golite062009
  • calmodulin binding
    		•  0.26906635924237 bayes_pls_golite062009
  • receptor binding
    		•  0.189665306346323 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle