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Protein Overview: Pkn-PB

General Information:
Name(s) found: Pkn-PB / FBpp0087682 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Protein kinase related to protein kinase N is referred to in FlyBase by the symbol Dmel\Pkn (CG2049, FBgn0020621). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5139815..5172602. It has the cytological map location 45C1. There is experimental evidence that it has the molecular function</span>: protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: dorsal closure. 44 alleles are reported. The phenotypes of these alleles are annotated with: dorsal closure embryo; anterior wing margin; wing margin bristle; posterior wing margin; wing; ommatidium; wing hair. It has 10 annotated transcripts and 10 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1190 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: dorsal closure [IMP][TAS]
    signal transduction [IEA]
    protein amino acid phosphorylation [ISS][NAS]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [IDA]
    protein serine/threonine kinase activity [ISS][NAS]
    protein kinase C activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSYYQGEY IKHPVLYELS HKYGFTENLP ESCMSIRLEE IKEAIRREIR KELKIKEGAE  60
   61 KLREVAKDRR SLSDVAVLVK KSKSKLAELK SELQELESQI LLTSANTAVN SNGQESITAC 120
  121 IDPNGGFLVS GAVGGLGGGN TALEGGAPAT ANDKVLASLE KQLQIEMKVK TGAENMIQSL 180
  181 GIGCDKKLLA EAHQMLADSK AKIEFLRLRI IKVKQNREQA DRLKASRQMI DEHGQTIGGN 240
  241 NSSQPQSLET TLEERIEELR HRLRIEAAVV DGAKNVIRTL QTANRAPDKK ALQEAHGRLS 300
  301 ESSRKLDLLR YSLDLRRQEL PADSPAAQQL KTELQIVQLS TSPAPVTYTS LQSGQAGILG 360
  361 GKPYQSVSSL GRCASVTGKL EVRLLGCQDL LEDVPGRSRR DKDNNSSPGD LRSFVKGVTS 420
  421 RSSSKSYSVK DETSIEIMAV IKLDNITVGQ TSWKQCSQQA WDQRFSIDLD RSRELEIGVY 480
  481 WRDWRSLCAV KVLRLEEFID DVRHGMALQL EPQGLLFAEV KFLNPMISQK PKLRRQRMIF 540
  541 NRQQAKNISR AKQMNINVAT WGRLLKRNAP NHVHMGSAGS GSSLTGSSPM VVGGSRDSES 600
  601 PISRTPSSDA LVEPEPYTPG EQAQNLEFDP DAGINEHVET PGEYPDPAAS GLSGMRPLSM 660
  661 HMQGISVLPP ESPPVATGAA GRPNTLSLQM PGASKGQVIQ GGRTAAPTTA PPPPPVLKAT 720
  721 STTPILDQEV IPQLGKLYVG SSQQQYAQQS SPIIQEPATP TIYGNSAAAG APQFPQPAQR 780
  781 QEKQPPQQQP IYANQYELNV AKAAAAASVY SPSSSTTSNS NQQQQQQRRN VARGLQYRES 840
  841 GGLETGRAGK QPPNAGMLSM DNFRLLSVLG RGHFGKVILS QLRSNNQYYA IKALKKGDII 900
  901 ARDEVESLLS EKRIFEVANA MRHPFLVNLY SCFQTEQHVC FVMEYAAGGD LMMHIHTDVF 960
  961 LEPRAVFYAA CVVLGLQYLH ENKIIYRDLK LDNLLLDTEG YVKIADFGLC KEGMGFGDRT1020
 1021 GTFCGTPEFL APEVLTETSY TRAVDWWGLG VLIFEMLVGE SPFPGDDEEE VFDSIVNDEV1080
 1081 RYPRFLSLEA IAVMRRLLRK NPERRLGSSE RDAEDVKKQA FFRSIVWDDL LLRKVKPPFV1140
 1141 PTINHLEDVS NFDEEFTSEK AQLTPPKEPR HLTEEEQLLF QDFSYTAEWC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..323] PSI-BLAST 22.39794 Heavy meromyosin subfragment
    2 View Details [324..419] deduced N/A No confident structure predictions are available.
    3 View Details [420..595] PSI-BLAST 12.522879 Human protein kinase C, eta
    4 View Details [596..1124] PSI-BLAST 62.522879 No description for 2h8hA was found.
    5 View Details [1125..1190] PSI-BLAST 105.0 No description for 2i0eA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle