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View Structure Prediction Details

Protein: Pkn-PB
Organism: Drosophila melanogaster
Length: 1190 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Pkn-PB.

Description E-value Query
Range
Subject
Range
Pkn-PF - The gene Protein kinase related to protein kinase N is referred to in FlyBase by the symbol Dmel\Pkn...
890.0 [0..5] [1190..20]

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Predicted Domain #1
Region A:
Residues: [1-323]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSYYQGEY IKHPVLYELS HKYGFTENLP ESCMSIRLEE IKEAIRREIR KELKIKEGAE  60
   61 KLREVAKDRR SLSDVAVLVK KSKSKLAELK SELQELESQI LLTSANTAVN SNGQESITAC 120
  121 IDPNGGFLVS GAVGGLGGGN TALEGGAPAT ANDKVLASLE KQLQIEMKVK TGAENMIQSL 180
  181 GIGCDKKLLA EAHQMLADSK AKIEFLRLRI IKVKQNREQA DRLKASRQMI DEHGQTIGGN 240
  241 NSSQPQSLET TLEERIEELR HRLRIEAAVV DGAKNVIRTL QTANRAPDKK ALQEAHGRLS 300
  301 ESSRKLDLLR YSLDLRRQEL PAD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.39794
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [324-419]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPAAQQLKTE LQIVQLSTSP APVTYTSLQS GQAGILGGKP YQSVSSLGRC ASVTGKLEVR  60
   61 LLGCQDLLED VPGRSRRDKD NNSSPGDLRS FVKGVT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [420-595]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRSSSKSYSV KDETSIEIMA VIKLDNITVG QTSWKQCSQQ AWDQRFSIDL DRSRELEIGV  60
   61 YWRDWRSLCA VKVLRLEEFI DDVRHGMALQ LEPQGLLFAE VKFLNPMISQ KPKLRRQRMI 120
  121 FNRQQAKNIS RAKQMNINVA TWGRLLKRNA PNHVHMGSAG SGSSLTGSSP MVVGGS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.522879
Match: 2fk9A
Description: Human protein kinase C, eta
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [596-1124]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDSESPISRT PSSDALVEPE PYTPGEQAQN LEFDPDAGIN EHVETPGEYP DPAASGLSGM  60
   61 RPLSMHMQGI SVLPPESPPV ATGAAGRPNT LSLQMPGASK GQVIQGGRTA APTTAPPPPP 120
  121 VLKATSTTPI LDQEVIPQLG KLYVGSSQQQ YAQQSSPIIQ EPATPTIYGN SAAAGAPQFP 180
  181 QPAQRQEKQP PQQQPIYANQ YELNVAKAAA AASVYSPSSS TTSNSNQQQQ QQRRNVARGL 240
  241 QYRESGGLET GRAGKQPPNA GMLSMDNFRL LSVLGRGHFG KVILSQLRSN NQYYAIKALK 300
  301 KGDIIARDEV ESLLSEKRIF EVANAMRHPF LVNLYSCFQT EQHVCFVMEY AAGGDLMMHI 360
  361 HTDVFLEPRA VFYAACVVLG LQYLHENKII YRDLKLDNLL LDTEGYVKIA DFGLCKEGMG 420
  421 FGDRTGTFCG TPEFLAPEVL TETSYTRAVD WWGLGVLIFE MLVGESPFPG DDEEEVFDSI 480
  481 VNDEVRYPRF LSLEAIAVMR RLLRKNPERR LGSSERDAED VKKQAFFRS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.522879
Match: 2h8hA
Description: No description for 2h8hA was found.

Predicted functions:

Term Confidence Notes
nucleotide binding 1.63195828048121 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [1125-1190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVWDDLLLRK VKPPFVPTIN HLEDVSNFDE EFTSEKAQLT PPKEPRHLTE EEQLLFQDFS  60
   61 YTAEWC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 105.0
Match: 2i0eA
Description: No description for 2i0eA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle