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Protein Overview: unpg-PA

General Information:
Name(s) found: unpg-PA / FBpp0087667 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene unplugged is referred to in FlyBase by the symbol Dmel\unpg (CG1650, FBgn0015561). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5082719..5087377. It has the cytological map location 45B3. There is experimental evidence that it has the molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: regulation of nervous system development; brain development; regulation of transcription. 9 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; embryonic/larval tracheal system; portion of tissue; tracheal system; cerebral anastomosis; adult segment; trachea; adult mesothoracic segment; ganglionic branch 2; thoracic segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 485 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][IDA]
    Biological Process: regulation of nervous system development [IMP]
    regulation of transcription, DNA-dependent [IEA]
    brain development [IMP]
    regulation of transcription [IEA][IMP]
    tracheal outgrowth, open tracheal system [TAS]
    open tracheal system development [TAS]
    Molecular Function: transcription factor activity [IMP]
    RNA polymerase II transcription factor activity [ISS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERPALLQNG EIGTMESPTT RLASKPFPKP FSIESLIANQ TPATATPPSP PEERDQEQEA  60
   61 EQEQELSARA MVASSALGLT QFPLYNPWLH GYFAQNHERL THLIAGGCYL PSSPAGHPAA 120
  121 QQPQAQAQPQ PPPPHPPTHA LEKQLPPTLP HPLDTRFLPF NPAAAGVAPT DLSYRRLAEL 180
  181 MNQDYVHSLS VHARLQHMAA AGRMHEDQAN PGMAQLQEPT PPQAHSSPAK SGSHSPMEPA 240
  241 LDVGMDEDFE CSGDSCSDIS LTMSPRNYNG EMDKSRNGAY TNSDSEDCSD DEGAQSRHEG 300
  301 GGMGGKDSQG NGSSSNSKSR RRRTAFTSEQ LLELEREFHA KKYLSLTERS QIATSLKLSE 360
  361 VQVKIWFQNR RAKWKRVKAG LTSHGLGRNG TTSGTKIVVP IPVHVNRFAV RSQHQQLEKM 420
  421 CLSGPKPDLR KKLSAEAIGG FEKFSGSTNA SSPSGGPVGL GVGVGVGVGV GLGVSTPLSL 480
  481 ARSIY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..112] MSA 9.250997 View MSA. No confident structure predictions are available.
    2 View Details [113..310] deduced N/A No confident structure predictions are available.
    3 View Details [311..394] PSI-BLAST 18.39794 DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
    4 View Details [395..485] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.20953772435302 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  0.876241359231159 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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