Protein Overview: Optix-PA

General Information:
Name(s) found:	Optix-PA / FBpp0087941 [FlyBase]
Description(s) found: Found 23 descriptions. SHOW ALL	The gene Optix is referred to in FlyBase by the symbol Dmel\Optix (CG18455, FBgn0025360). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3919138..3930041. It has the cytological map location 44A3. Based on sequence similarity, it is predicted to have molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: compound eye photoreceptor cell differentiation; compound eye development; compound eye morphogenesis. 7 alleles are reported. The phenotypes of these alleles are annotated with: eye; antenna; ommatidium. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	487 amino acids
Gene Ontology:
Cellular Component:	nucleus [ISS][NAS]
Biological Process:	compound eye photoreceptor cell differentiation [IMP] compound eye morphogenesis [IMP] regulation of transcription, DNA-dependent [IEA] regulation of transcription [IEA][NAS] compound eye development [IEP][NAS]
Molecular Function:	DNA binding [ISS] transcription factor activity [IEA][NAS] RNA polymerase II transcription factor activity [NAS] sequence-specific DNA binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVGPTEGKQ PPSESFSPTH HQIIAPSPIL AVPTLAFSAA QVEIVCKTLE DSGDIERLAR  60
   61 FLWSLPVALP NMHEILNCEA VLRARAVVAY HVGNFRELYA IIENHKFTKA SYGKLQAMWL 120
  121 EAHYIEAEKL RGRSLGPVDK YRVRKKFPLP PTIWDGEQKT HCFKERTRSL LREWYLQDPY 180
  181 PNPTKKRELA KATGLNPTQV GNWFKNRRQR DRAAAAKNRI QHSQNSSGMG CRSRRADGAA 240
  241 SPTPSDSSDS DISLGTHSPV PSSLQLQHSP GSTSNGANDR EESLSVDDDK PRDLSGSLPL 300
  301 PLSLPLPLAS PTHTPPQLPP GYGGGAGAGP GGPLTGPGCL PPFKLDAATS LFSAGCYLQS 360
  361 FSNLKEMSQQ FPIQPIVLRP HPQLPQSLAL NGASGGPPLH HPAYAAAYSV ECVPGGHGPP 420
  421 HPPPKLRINS PEKLNSTAVA AAASVGGGGG NQHHEPTTTG YHHSGQLMLH RPFSTSPELK 480
  481 HSAPEIT

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..129]	PSI-BLAST	22.154902	Complex of LMO4 LIM domains 1 and 2 with the ldb1 LID domain
2	View Details	[130..224]	PSI-BLAST	15.30103	Paired protein
3	View Details	[225..387]	deduced	N/A	No confident structure predictions are available.
4	View Details	[388..487]	MSA	7.208997	View MSA. No confident structure predictions are available.

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
transcription regulator activity	4.00967542385368	bayes_pls_golite062009
DNA binding	3.60745514727532	bayes_pls_golite062009
nucleic acid binding	3.16757861573985	bayes_pls_golite062009
binding	2.96409924710655	bayes_pls_golite062009
transcription factor activity	2.90769972671972	bayes_pls_golite062009
sequence-specific DNA binding	1.62841402245495	bayes_pls_golite062009
transcription activator activity	1.62405765585032	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.50210964370113	bayes_pls_golite062009
ligand-dependent nuclear receptor activity	1.49515149729803	bayes_pls_golite062009
protein binding	1.39455913713025	bayes_pls_golite062009
transcription factor binding	1.38523780690867	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.68270103300828	bayes_pls_golite062009
transcription cofactor activity	0.58115018700114	bayes_pls_golite062009
transcription repressor activity	0.256420113528322	bayes_pls_golite062009
catalytic activity	0.101795606736461	bayes_pls_golite062009

2

Term	Confidence	Notes
transcription regulator activity	5.13863038737912	bayes_pls_golite062009
DNA binding	4.66369707598026	bayes_pls_golite062009
nucleic acid binding	4.20953772435302	bayes_pls_golite062009
transcription factor activity	4.06706589695599	bayes_pls_golite062009
binding	3.02779747447702	bayes_pls_golite062009
sequence-specific DNA binding	2.41271657675151	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.26183812259792	bayes_pls_golite062009
transcription repressor activity	1.91962622287073	bayes_pls_golite062009
transcription activator activity	1.77700860354597	bayes_pls_golite062009
transcription factor binding	1.40653841901929	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.14886080629275	bayes_pls_golite062009
chromatin binding	0.876241359231159	bayes_pls_golite062009
transcription cofactor activity	0.84983974758882	bayes_pls_golite062009
protein binding	0.830419844171551	bayes_pls_golite062009
transcription corepressor activity	0.25931464844298	bayes_pls_golite062009

3

No functions predicted.

4

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.94

Source: Reynolds et al. (2008)

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