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Protein Overview: Orc1-PA

General Information:
Name(s) found: Orc1-PA / FBpp0088033 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Origin recognition complex subunit 1 is referred to in FlyBase by the symbol Dmel\Orc1 (CG10667, FBgn0022772). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3409940..3413213. It has the cytological map location 43D1-43D2. It is reported to have molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: DNA amplification; DNA replication initiation; cell proliferation. 15 alleles are reported. The phenotypes of these alleles are annotated with: chorion; eye; interommatidial bristle; egg; ommatidium; dorsal appendage; stage S10B oocyte; morphogenetic furrow. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 924 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    nuclear origin of replication recognition complex [IDA][ISS][NAS]
    Biological Process: cell proliferation [IMP]
    DNA replication initiation [IDA]
    DNA replication [IEA]
    DNA-dependent DNA replication [ISS][NAS]
    DNA amplification [IMP]
    chromatin silencing [NAS]
    Molecular Function: DNA binding [IEA][NAS]
    ATP binding [IEA]
    nucleoside-triphosphatase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNKENARSV GQQVKWIGSQ DELPPVKNLE HKNVYFYQKC IYGPLTLSVG DFILVSNADA  60
   61 AEPDTVSGCD VARILHMYEL RELTDREPCR AIVQWYSWPK AIPHNKYDDD EVAIDFSLEV 120
  121 IEEHRPYDND VALGAIYRKC IVLEGTSKTS AEEILKRHAN KLKSTACPMF VSRYRFVKVK 180
  181 RSYRLIPLEI HLEQPEDNAR PTRSSRKSLT AHRESKRSIS ARHDDTAGNK GSSVEKRRRA 240
  241 SMAASSSVEF IDVNSFICEN KVSPIKIVGG RSVVRLSEKK NAPEINANYL PASPLTEKNA 300
  301 KVETPKSRAS AARRNLNLSL DRGADTTADS DCLNYSIVQQ TPDPKTPSND MKIKLRLSER 360
  361 RRSVRLASMD VDPLSLEEAV QEPNAQGRKR LGVANGDIYH TPTKKSKEPL ESAAATEQTP 420
  421 STRRKSILKS ATSRLAEGTP RRSIHLSNIV EQRVFEDDEI ISTPKRGRSK KTVQDNDEDY 480
  481 SPKKSVQKTP TRTRRSSTTT KTATTPSKGI TTATATPMTP SQKMKKIRAG ELSPSMQQRT 540
  541 DLPAKDSSKS ELQLAREQLH VSVVPKSLPC REREFENIYA FLEGKIQDQC GGCMYVSGVP 600
  601 GTGKTATVTG VIRTLQRMAK QNELPAFEYL EINGMRLTEP RQAYVQIYKQ LTGKTVSWEQ 660
  661 AHALLEKRFT TPAPRRVTTV LLVDELDILC NRRQDVVYNL LDWPTKSAAK LVVVTIANTM 720
  721 DLPERLLMGK VTSRLGLTRL TFQPYSHKQL QEIVTARLGG SETFKGEAVQ LVARKVAAVS 780
  781 GDARRALDIC RRATEIADTA AVKCVTMLHV QQALAEMIAS AKVQAIRNCS RMEQIFLQAI 840
  841 AAEVTRTGVE ETTFMGVYQQ VETIAAFMGV TFPPPGRALR LCSKLGAERL IISEHSRNDL 900
  901 FQKILLNVSA DDIHYALRVE EMVN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..152] FFAS03 2.27 Crystal structure of the proximal BAH domain of polybromo
    2 View Details [153..411] MSA 3.212994 View MSA. No confident structure predictions are available.
    3 View Details [412..541] deduced N/A No confident structure predictions are available.
    4 View Details [542..924] PSI-BLAST 54.69897 No description for 2qbyA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle