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Protein Overview: BubR1-PA

General Information:
Name(s) found: BubR1-PA / FBpp0085368 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Bub1-related kinase is referred to in FlyBase by the symbol Dmel\BubR1 (CG7838, FBgn0025458). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:1856600..1862122. It has the cytological map location 42A5-42A6. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of exit from mitosis; mitotic cell cycle spindle assembly checkpoint; mitotic spindle organization; syncytial blastoderm mitotic cell cycle; spindle checkpoint. 12 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: anatomical structure; spindle; cell cycle; protein complex; organ system; intracellular non-membrane-bounded organelle; intracellular organelle part; intracellular organelle; spindle microtubule; developing anatomical structure. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1460 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    kinetochore [IDA][TAS]
    outer kinetochore of condensed chromosome [NAS]
    Biological Process: mitotic cell cycle spindle assembly checkpoint [IDA][IMP][ISS][TAS]
    regulation of exit from mitosis [IGI][IMP]
    mitotic spindle organization [IMP]
    syncytial blastoderm mitotic cell cycle [IMP]
    protein amino acid phosphorylation [IEA][NAS]
    spindle checkpoint [IMP]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [NAS]
    protein serine/threonine kinase activity [IEA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFDNAKENI QPLASGRNVS LLQASLSQDS THGQELLAQR KQMEEEVRTY KGADPLGAWY  60
   61 TFICWIEQSY PAGGSGSGLQ TVLHQCLTKF EDDERYRQDK RLIKLFIKFM EKQKDKIEFY 120
  121 QQMYNNGIGT MLADFYIAWA YSYDLSGNMR KADEIFRLGL ECRAEPLEDL KEAHHHFGYT 180
  181 VGQRMLYSTG EEANAVNQEL NERRLALQSL HGRRQQISNS ITVGSIRTGA AVKSGLPGVV 240
  241 QVEPSTTTSR RNVGRNVEVF NDENSEGNIP ISNSETEVKS SLRSIIDSAC SQENIKEPVA 300
  301 WNKANAKRHK HGKIFGSNAS PDLGFDIHVD EQAMPPITNY ERRLEQPFRF PTNFVAKNRP 360
  361 QEPWVTPVTI EDEPNASGLP CYNKCLLYPR PNIEFSPEEY RAYSFLKHRN PQHPFIHRND 420
  421 DWWGTGRVIR GIRCYPNFAR YSKPQDLDEL DKFWKPPLVP GLQVVFDKIY NEVEQKEYQP 480
  481 EELLAAKWME KRNVTVHGDF DMEETVCLPG NKMPRRKSFF PSSFRKSIMP RRVSSVQEED 540
  541 EKKEDEATLI VKDIPSQVAP KIPESPCDQI DEPKIKIFED SGSPRDNFAV PAVPVPKIEI 600
  601 YEDSEEPQPT PKTRPFYDGD ETCSTQMFNM FIKSQAVSTP KGTQKQAPSR QFGTVLKELP 660
  661 LPEEAAHSVE SPVETRSPTL RKQLSTILET SEHGTQSLAT SGTTTKSTIT STSSPGSNAV 720
  721 SKLGSKIEEN TPGQMRLQRV ISAGVSAVLS EPEKPGGDNF LRRELWEPNA PSVPMLKSLR 780
  781 FQEDKTETIP RPLACFQEDK TETLPQMPIA LPENSMDHGS LGAENCFSAP QLPTLEDESD 840
  841 LCGLFGKTPP KTNIFGSPKR NFDPTSQLFK STQGDRRSFA VTGNKLEAAP SISNLQDSFM 900
  901 CDLSFVPETQ PEAVAKSGAI QKFDIFLDDT QPKLTKSKPV ALMVSSFDLD CTLPETQQVA 960
  961 IKEPGTQQEN IGHSHMIASF MKDCTEIGSC PSQMPASVVK TNISSTSNKI KFSNDSMSES1020
 1021 SRKAPVNENV GISKQPDEFF ELNAATEMFA TNISMIKNST LLIPNAKVAE ASELSIYYKT1080
 1081 TPLTPKQSHR SWSQSDLETP PRENFVHPTS NGDQTVLNET LADANKNPFN VELISSLLES1140
 1141 IDFSMYIEKL PHCQLVGHVK RLHPNTHLEV HNEKFEVSKM IGKGAYGSVY VGKHLKSGKK1200
 1201 VALKQERPTN YWEFYICLEI HSRLTSEQMI PSYAHIDYAL VGNNSSVYIS EFSDYGSLIG1260
 1261 VCNKVKSVTN RNMDEYVVMH LSCQMLDIVD HLHAMGIIHA DIKPDNFLLM KPICADPNEV1320
 1321 SLQLIDFGVS IDMKLFPDNQ TFNYVHHDDL FKCIEMRTGR PWTYQLDLYG LVSVMHVLLF1380
 1381 GRYMEVVQRS PSTIWMPKTN VPRYFQRTMW ENIFRTLLNI RDCRTMPNLQ QLRTQLKCAL1440
 1441 AEKEKYVAEA ISKFNTILQK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..294] FFAS03 1.06 No description for 2uy1A was found.
    2 View Details [295..360] deduced N/A No confident structure predictions are available.
    3 View Details [361..603] deduced N/A No confident structure predictions are available.
    4 View Details [604..694] deduced N/A No confident structure predictions are available.
    5 View Details [695..894] deduced N/A No confident structure predictions are available.
    6 View Details [895..1156] deduced N/A No confident structure predictions are available.
    7 View Details [1157..1460] PSI-BLAST 76.39794 No description for 2jdoA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
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