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Protein Overview: ap-PA

General Information:
Name(s) found: ap-PA / FBpp0085394 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • The gene apterous is referred to in FlyBase by the symbol Dmel\ap (CG8376, FBgn0000099). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:1593707..1614335. It has the cytological map location 41F8. Based on sequence similarity, it is predicted to have molecular function</span>: specific RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: nervous system development; wing disc dorsal/ventral pattern formation; histolysis; muscle organ development; leg disc development; leg segmentation; axon guidance; leg disc proximal/distal pattern formation; transcription. 100 alleles are reported. The phenotypes of these alleles are annotated with 79 unique terms, many of which group under: adult segment; hypodermal muscle of larval abdomen; adult mesothoracic segment; abdominal transverse muscle; larval abdominal segment 5; embryonic nervous system; peripheral nervous system; postalar bristle; organ system; adult somatic muscle. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 469 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: leg segmentation [IMP]
    wing disc morphogenesis [NAS]
    transcription [IMP][TAS]
    dorsal/ventral pattern formation, imaginal disc [TAS]
    dorsal/ventral lineage restriction, imaginal disc [TAS]
    haltere disc morphogenesis [NAS]
    nervous system development [IMP][TAS]
    imaginal disc-derived wing morphogenesis [TAS]
    axon guidance [IMP]
    regulation of transcription, DNA-dependent [IEA]
    leg disc proximal/distal pattern formation [IMP]
    muscle organ development [IMP][TAS]
    histolysis [IMP]
    cell fate commitment [NAS]
    wing disc dorsal/ventral pattern formation [IGI][IMP][TAS]
    leg disc development [IMP]
    Molecular Function: zinc ion binding [IEA][NAS]
    transcription factor activity [IEA]
    specific RNA polymerase II transcription factor activity [ISS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVCTEERPV MHWQQSARFL GPGAREKSPT PPVAHQGSNQ CGSAAGANNN HPLFRACSSS  60
   61 SCPDICDHST KPFGNAYGTE SFRSYETADR ATFEDSAAKF SISRSRTDCT EVSDETTSGI 120
  121 SFKTEPFGPP SSPESTSDSK ITRNLDDCSG CGRQIQDRFY LSAVEKRWHA SCLQCYACRQ 180
  181 PLERESSCYS RDGNIYCKND YYSFFGTRRC SRCLASISSN ELVMRARNLV FHVNCFCCTV 240
  241 CHTPLTKGDQ YGIIDALIYC RTHYSIAREG DTASSSMSAT YPYSAQFGSP HNDSSSPHSD 300
  301 PSRSIVPTGI FVPASHVING LPQPARQKGR PRKRKPKDIE AFTANIDLNT EYVDFGRGSH 360
  361 LSSSSRTKRM RTSFKHHQLR TMKSYFAINH NPDAKDLKQL SQKTGLPKRV LQVWFQNARA 420
  421 KWRRMMMKQD GSGLLEKGEG ALDLDSISVH SPTSFILGGP NSTPPLNLD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..82] deduced N/A No confident structure predictions are available.
    2 View Details [83..185] FFAS03 0.967 Cysteine-rich (intestinal) protein, CRP, CRIP
    3 View Details [186..266] PSI-BLAST 16.221849 No description for 2dfyX was found.
    4 View Details [267..361] deduced N/A No confident structure predictions are available.
    5 View Details [362..469] PSI-BLAST 7.0 No description for 2dmqA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle