Protein Overview: ik2-PA

General Information:
Name(s) found:	ik2-PA / FBpp0080919 [FlyBase]
Description(s) found: Found 17 descriptions. SHOW ALL	The gene IĂ?Ă?ÂşB kinase-like 2 is referred to in FlyBase by the symbol Dmel\ik2 (CG2615, FBgn0086657). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:20676234..20679308. It has the cytological map location 38D4-38E2. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of caspase activity; neuron remodeling; maintenance of epithelial integrity, open tracheal system; cell morphogenesis; actin filament organization; cell death. 25 alleles are reported. The phenotypes of these alleles are annotated with: embryonic tracheole; eye; interommatidial bristle; macrochaeta; arista lateral; humeral bristle; terminal tracheal cell; border follicle cell. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	711 amino acids
Gene Ontology:
Cellular Component:	IkappaB kinase complex [NAS]
Biological Process:	positive regulation of caspase activity [IMP] cell death [IMP] signal transduction [NAS] cell morphogenesis [IMP] actin filament organization [IMP] maintenance of epithelial integrity, open tracheal system [IMP] protein amino acid phosphorylation [IEA][NAS] defense response [NAS] neuron remodeling [IMP]
Molecular Function:	ATP binding [IEA] protein binding [IPI] IkappaB kinase activity [NAS] protein kinase activity [NAS] protein serine/threonine kinase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFLRGSVSY VWCTTSVLGK GATGSVFQGV NKITGESVAV KTFNPYSHMR PADVQMREFE  60
   61 ALKKVNHENI VKLLAIEEDQ EGRGKVIVME LCTGGSLFNI LDDPENSYGL PEHEFLLVLE 120
  121 HLCAGMKHLR DNKLVHRDLK PGNIMKFISE DGQTIYKLTD FGAARELEDN QPFASLYGTE 180
  181 EYLHPDLYER AVLRKSIQRS FTANVDLWSI GVTLYHVATG NLPFRPFGGR KNRETMHQIT 240
  241 TKKASGVISG TQLSENGPIE WSTTLPPHAH LSQGLKTLVT PLLAGLLEEN REKTWSFDRF 300
  301 FHEVTLILRK RVIHVFFTNR TSSVEVFLEP DEQIDNFRER IFLQTEVPLE KQILLFNNEH 360
  361 LEKKVTPRTI DQPIFLYSND DNNVQLPQQL DLPKFPVFPP NVSVENDASL AKSACSVGHE 420
  421 CKRRVDIFTS MDILIKKGVE HFIEMLVTTI TLLLKKTESF DNLLSTVIDY ADVVHSMARV 480
  481 TKGDQEIKTL LTALENVKSD FDGAADVISQ MHKHFVIDDE LNDQWTSSMH GKKCPCKTRA 540
  541 SAQAKYLVER LRDSWQHLLR DRATRTLTYN DEQFHALEKI KVDHNGKRIK ALLLDNVNPT 600
  601 VAQIAECLAD WYKLAQTVYL KTQILEKDVR DCERKLNGIR DELYHVKSEL KLDVDTKTIN 660
  661 NNNQLAKIEE RNRLRVMQQQ QQEVMAVMRT NSDIISLLSK LGITNGSLES S

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: ik2-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: