Protein Overview: hkl-PA, FBpp0307...

General Information:
Name(s) found:	FBpp0307803 [FlyBase] hkl-PA / FBpp0080689 [FlyBase] hkl-PB / FBpp0080688 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7298527\|gb\|AAF53746.1\| hook-like, isoform A [Drosophila melanogaster] [NCBI NR] gi\|24585110\|ref\|NP_724153.1\| hook-like, isoform B [Drosophila melanogaster] [NCBI NR] gi\|22946800\|gb\|AAN11023.1\| hook-like, isoform B [Drosophila melanogaster] [NCBI NR] gi\|20129613\|ref\|NP_609935.1\| hook-like, isoform A [Drosophila melanogaster] [NCBI NR] gi\|17862374\|gb\|AAL39664.1\| LD23757p [Drosophila melanogaster] [NCBI NR] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0307803; name=Acn-PC; parent=FBgn0263198,FBtr0336842; dbxref=FlyBase:FBpp0307803,FlyBase_Annotation_IDs:CG10473-PC,REFSEQ:NP_001260556,GB_protein:AGB93091; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r5.56; species=Dmel; [FlyBase] The gene hook-like is referred to in FlyBase by the symbol Dmel\hkl (CG10473, FBgn0086441). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:19045361..19048633. It has the cytological map location 37B11-37B12. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: nucleotide binding. There is experimental evidence that it is involved in the biological process</span>: protein targeting to lysosome. 23 alleles are reported. The phenotype of these alleles is annotated with: melanotic mass. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] >CG10473-PA translation from_gene[CG10473 CG10473 FBgn0032745] seq_release:3 mol_weight=83720 cds_boundaries:(2L:19,023,650..19,026,176[+]) aa_length:739 transcript_info:[CG10473-RA seq_release:3] gene_info:[gene symbol:CG10473 FBgn0032745 gene_boundar [hmr_yeast5_DM3-1_pombe.fasta] >CG10473-PB translation from_gene[CG10473 CG10473 FBgn0032745] seq_release:3 mol_weight=83720 cds_boundaries:(2L:19,023,650..19,026,176[+]) aa_length:739 transcript_info:[CG10473-RB seq_release:3] gene_info:[gene symbol:CG10473 FBgn0032745 gene_boundar [hmr_yeast5_DM3-1_pombe.fasta] (Q9VJ12) CG10473 protein (LD23757p) [DrosMelano7227.FASTAC.txt] (AE003661) CG10473 gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG10473-PB, isoform B [Drosophila melanogaster]gi\|7298527\|gb\|AAF53746.1\| CG10473-PA, isoform A [Drosophila melanogaster]gi\|17862374\|gb\|AAL39664.1\| LD23757p [Drosophila melanogaster]gi\|24585110\|ref\|NP_724153.1\| CG10473-PB [Drosophila melanogaster]gi\|20 [nrdb_11152004_Chlamydomonas] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080688; name=hkl-PB; parent=FBgn0086441,FBtr0081144; dbxref=FlyBase:FBpp0080688,FlyBase_Annotation_IDs:CG10473-PB,GB_protein [fly-100309-contam.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080689; name=hkl-PA; parent=FBgn0086441,FBtr0081145; dbxref=FlyBase:FBpp0080689,FlyBase_Annotation_IDs:CG10473-PA,GB_protein [fly-100309-contam.fasta] LD23757p [Drosophila melanogaster] [nr-271106-contam.fasta] CG10473-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] CG10473-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080688; name=hkl-PB; parent=FBgn0086441,FBtr0081144; dbxref=FlyBase:FBpp0080688,FlyBase_Annotation_IDs:CG10473-PB,GB_protein:AAN11023.1,REFSEQ:NP_724153,GB_protein:AAN11023; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080689; name=hkl-PA; parent=FBgn0086441,FBtr0081145; dbxref=FlyBase:FBpp0080689,FlyBase_Annotation_IDs:CG10473-PA,GB_protein:AAF53746.1,REFSEQ:NP_609935,GB_protein:AAF53746; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080688; name=hkl-PB; parent=FBgn0086441,FBtr0081144; dbxref=FlyBase:FBpp0080688,FlyBase_Annotation_IDs:CG10473-PB,GB_protein:AAN11023.1,REFSEQ:NP_724153,GB_protein:AAN11023; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080689; name=hkl-PA; parent=FBgn0086441,FBtr0081145; dbxref=FlyBase:FBpp0080689,FlyBase_Annotation_IDs:CG10473-PA,GB_protein:AAF53746.1,REFSEQ:NP_609935,GB_protein:AAF53746; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Hook-like, isoform A OS=Drosophila melanogaster GN=Acn PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080689; name=Acn-PA; parent=FBgn0263198,FBtr0081145; dbxref=FlyBase:FBpp0080689,FlyBase_Annotation_IDs:CG10473-PA,GB_protein:AAF53746.1,REFSEQ:NP_609935,GB_protein:AAF53746; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080688; name=Acn-PB; parent=FBgn0263198,FBtr0081144; dbxref=FlyBase:FBpp0080688,FlyBase_Annotation_IDs:CG10473-PB,GB_protein:AAN11023.1,REFSEQ:NP_724153,GB_protein:AAN11023,FlyMine:FBpp0080688,modMine:FBpp0080688; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] Hook-like, isoform A OS=Drosophila melanogaster GN=Acn PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080689; name=Acn-PA; parent=FBgn0263198,FBtr0081145; dbxref=FlyBase:FBpp0080689,FlyBase_Annotation_IDs:CG10473-PA,GB_protein:AAF53746.1,REFSEQ:NP_609935,GB_protein:AAF53746; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080688; name=Acn-PB; parent=FBgn0263198,FBtr0081144; dbxref=FlyBase:FBpp0080688,FlyBase_Annotation_IDs:CG10473-PB,GB_protein:AAN11023.1,REFSEQ:NP_724153,GB_protein:AAN11023,FlyMine:FBpp0080688,modMine:FBpp0080688; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0307803; name=Acn-PC; parent=FBgn0263198,FBtr0336842; dbxref=FlyBase:FBpp0307803,FlyBase_Annotation_IDs:CG10473-PC,REFSEQ:NP_001260556,GB_protein:AGB93091; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080689; name=Acn-PA; parent=FBgn0263198,FBtr0081145; dbxref=FlyBase:FBpp0080689,FlyBase_Annotation_IDs:CG10473-PA,GB_protein:AAF53746.1,REFSEQ:NP_609935,GB_protein:AAF53746; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080688; name=Acn-PB; parent=FBgn0263198,FBtr0081144; dbxref=FlyBase:FBpp0080688,FlyBase_Annotation_IDs:CG10473-PB,GB_protein:AAN11023.1,REFSEQ:NP_724153,GB_protein:AAN11023,FlyMine:FBpp0080688,modMine:FBpp0080688; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0307803; name=Acn-PC; parent=FBgn0263198,FBtr0336842; dbxref=FlyBase:FBpp0307803,FlyBase_Annotation_IDs:CG10473-PC,REFSEQ:NP_001260556,GB_protein:AGB93091; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Acinus, isoform A OS=Drosophila melanogaster GN=Acn PE=1 SV=1 [DROME.fasta.20160308] FBpp0080689 type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080689; name=Acn-PA; parent=FBgn0263198,FBtr0081145; dbxref=FlyBase:FBpp0080689,FlyBase_Annotation_IDs:CG10473-PA,GB_protein:AAF53746.1,REFSEQ:NP_609935,GB_protein:AAF53746; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0080688 type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080688; name=Acn-PB; parent=FBgn0263198,FBtr0081144; dbxref=FlyBase:FBpp0080688,FlyBase_Annotation_IDs:CG10473-PB,GB_protein:AAN11023.1,REFSEQ:NP_724153,GB_protein:AAN11023,FlyMine:FBpp0080688,modMine:FBpp0080688; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0307803 type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0307803; name=Acn-PC; parent=FBgn0263198,FBtr0336842; dbxref=FlyBase:FBpp0307803,FlyBase_Annotation_IDs:CG10473-PC,REFSEQ:NP_001260556,GB_protein:AGB93091; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080689; name=Acn-PA; parent=FBgn0263198,FBtr0081145; dbxref=FlyBase:FBpp0080689,FlyBase_Annotation_IDs:CG10473-PA,GB_protein:AAF53746.1,REFSEQ:NP_609935,GB_protein:AAF53746,UniProt/TrEMBL:Q9VJ12; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0080688; name=Acn-PB; parent=FBgn0263198,FBtr0081144; dbxref=FlyBase:FBpp0080688,FlyBase_Annotation_IDs:CG10473-PB,GB_protein:AAN11023.1,REFSEQ:NP_724153,GB_protein:AAN11023,UniProt/TrEMBL:Q9VJ12,FlyMine:FBpp0080688,modMine:FBpp0080688; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=2L:join(19045567..19047047,19047152..19047362,19047420..19047654,19047716..19047825,19047914..19048096); ID=FBpp0307803; name=Acn-PC; parent=FBgn0263198,FBtr0336842; dbxref=FlyBase:FBpp0307803,FlyBase_Annotation_IDs:CG10473-PC,REFSEQ:NP_001260556,GB_protein:AGB93091,UniProt/TrEMBL:Q9VJ12; MD5=42fbd866a3c5a1c639bc00c4a3eb2892; length=739; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	739 amino acids
Gene Ontology:
Cellular Component:	nucleus [ISS] catalytic step 2 spliceosome [IDA] precatalytic spliceosome [IDA]
Biological Process:	apoptosis [ISS] protein targeting to lysosome [IMP] nuclear mRNA splicing, via spliceosome [IC]
Molecular Function:	nucleotide binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRRSERKKS SSPAPVPVAV ARRSRRSRKV SENEKTEVET PVVAQNNEAE CPKVPPASQE  60
   61 INEARASSEE RAGSGASPVR RSRGSRTTPR KRTESKGGDK KVDTIPEEEP ENGKDVEKDA 120
  121 VEEEKTVAPP AANESESEDR AKTEDQQAQD DESCAEPAVV KDDDVEKEDL KPQQEVPTST 180
  181 DDDTKQSEPE QEVKVPSPSS KDEEHLKTTS DVLDIQTEEV DERDEEASAP AERRETKKRH 240
  241 KEQIKEQQPA EEEEHKENHK QIDENPEQIH DEPADLSNDK HDPCLNSSAT NTTGAPVLQQ 300
  301 QRSVRKRKWL TNKKSSDRTP PVLAISTDSL KNIIADVVQP VPLSDVQLES SSEEEGLVTS 360
  361 DRDSERSASP APPSEASKDR DNKGNTANTC DTTAEASADN EGAGAAPPAA ADTVSAQVSL 420
  421 SKATVSTAAP HIVRDPSPAR NRASHVLYIT NLVRPFTVLQ LKGLLARTGK IVEEDGFWID 480
  481 RIKSKCYVAY STEDEAIETR HALHGVRWPV SNPKCLNVDF GSRTDMDRAI LSTKDEAPRY 540
  541 GQENTRDNQQ SGNAWSRLEP SDKKPARPVR EWDVGKKEPS DHDKHSNDRR RDSKDRLDSR 600
  601 SRDAERAGQE RKRSRDREGR GRDRERERLD RNAHARSRSG SPASKTKKEN EPPIRLLDDL 660
  661 FRKTKGTPCI YWLPLTPEAI AEKEAFRQKR IEEHKLRIKE REERQKEREK DRDRQRETRR 720
  721 NRSNERRRSR SRERERRRY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: hkl-PA, FBpp0307...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: