Protein Overview: Sec61alpha-PA, F...

General Information:
Name(s) found:	FBpp0311774 [FlyBase] Sec61alpha-PA / FBpp0078896 [FlyBase]
Description(s) found: Found 28 descriptions. SHOW ALL	type=protein; loc=2L:complement(6477634..6477897,6477971..6479062,6480034..6480101,6480324..6480330); ID=FBpp0311774; name=Sec61alpha-PB; parent=FBgn0086357,FBtr0345753; dbxref=FlyBase:FBpp0311774,FlyBase_Annotation_IDs:CG9539-PB; MD5=7ebf272103cd1edb2363bdc448a608ca; length=476; release=r5.56; species=Dmel; [FlyBase] The gene Sec61Ă?Ă?Âą is referred to in FlyBase by the symbol Dmel\Sec61Ă?Ă?Âą (CG9539, FBgn0086357). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:6477178..6480489. It has the cytological map location 26D7-26D8. Based on sequence similarity, it is predicted to have molecular function</span>: protein transporter activity. There is experimental evidence that it is involved in the biological process</span>: endoplasmic reticulum unfolded protein response; dorsal closure; lysosome organization; cuticle development; head involution; cell death; negative regulation of autophagy. 25 alleles are reported. The phenotypes of these alleles are annotated with: crystal cell; denticle belt. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	476 amino acids
Gene Ontology:
Cellular Component:	Sec61 translocon complex [ISS]
Biological Process:	dorsal closure [IMP] SRP-dependent cotranslational protein targeting to membrane, translocation [ISS] lysosome organization [IMP] cell death [IMP] endoplasmic reticulum unfolded protein response [IMP] negative regulation of autophagy [IMP] head involution [IMP] cuticle development [IMP]
Molecular Function:	P-P-bond-hydrolysis-driven protein transmembrane transporter activity [IEA] protein transporter activity [ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIKFLEVIK PFCSILPEIA KPERKIQFRE KVLWTAITLF IFLVCCQIPL FGIMSSDSAD  60
   61 PFYWIRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII EVGDTPKDRA LFNGAQKLFG 120
  121 MVITIGQAIV YVMTGMYGDP SEIGAGVCLL IIIQLFAAGL IVLLLDELLQ KGYGLGSGIS 180
  181 LFIATNICET IVWKAFSPTT VTTGRGTEFE GAVIALFHLM ATRNDKVRAL REAFYRQNLP 240
  241 NLMNLLATVL VFAVVIYFQG FRVDLPIKSA RYRGQYSSYP IKLFYTSNIP IILQSALVSN 300
  301 LYVISQMLAV KFQGNFFINL LGVWADVGGG GPARSYPIGG LCYYLSPPES VGHILTDPIH 360
  361 ALLYIVFMLG SCAFFSKTWI DVSGSSAKDV AKQLKEQHMV MRGHRENSMI HELNRYIPTA 420
  421 AAFGGLCIGA LSVMADFLGA IGSGTGILLA VTIIYQYFEI FVKEQSEMGG MGTLLF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: Sec61alpha-PA, F...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: